pdf: Neuroprotection by spice-derived nutraceuticals

[Guest guest]

open access:

Neuroprotection by spice-derived nutraceuticals: you are what you eat!

<http://www.ncbi.nlm.nih.gov/pubmed/21360003>

Kannappan R, Gupta SC, Kim JH, Reuter S, Aggarwal BB.

Mol Neurobiol. 2011 Oct;44(2):142-59.

Numerous lines of evidence indicate that chronic inflammation plays a

major role in the development of various neurodegenerative diseases,

including Alzheimer's disease, Parkinson's disease, multiple sclerosis,

brain tumor, and meningitis. Why these diseases are more common among

people from some countries than others is not fully understood, but

lifestyle factors have been linked to the development of

neurodegenerative diseases. For example, the incidence of certain

neurodegenerative diseases among people living in the Asian

subcontinent, where people regularly consume spices, is much lower than

in countries of the western world. Extensive research over the last 10

years has indicated that nutraceuticals derived from such spices as

turmeric, red pepper, black pepper, licorice, clove, ginger, garlic,

coriander, and cinnamon target inflammatory pathways, thereby may

prevent neurodegenerative diseases. How these nutraceuticals modulate

various pathways and how they exert neuroprotection are the focus of

this review.