[Fwd: Bacterial production of methylglyoxal - E. coli - Insulin resistance as a bonus]

[Guest guest]

Significance to autism in cite-7. Methylglyoxal is a normally occurring

molecule endogenous to humans (8), influences glutathione (9), augments

insulin resistance (eg, 8,10), and can be produced by various bacteria

(eg, E. coli).

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1. Accumulation of methylglyoxal in anaerobically grown Escherichia coli

and its detoxification by expression of the Pseudomonas putida

glyoxalase I gene. <http://www.ncbi.nlm.nih.gov/pubmed/11461144>

Zhu MM, Skraly FA, Cameron DC.

Metab Eng. 2001 Jul;3(3):218-25.

2. The crystal structure of methylglyoxal synthase from Escherichia

coli. <http://www.ncbi.nlm.nih.gov/pubmed/10368300>

Saadat D, on DH.

Structure. 1999 Mar 15;7(3):309-17.

3. Metabolic flux analysis of Escherichia coli in glucose-limited

continuous culture. II. Dynamic response to famine and feast, activation

of the methylglyoxal pathway and oscillatory behaviour.

<http://www.ncbi.nlm.nih.gov/pubmed/15758217>

Weber J, Kayser A, Rinas U.

Microbiology. 2005 Mar;151(Pt 3):707-16.

4. Bacterial production of methylglyoxal: a survival strategy or death

by misadventure? <http://www.ncbi.nlm.nih.gov/pubmed/14641075>

Booth IR, Ferguson GP, S, Li C, Gunasekera B, Kinghorn S.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1406-8. Review.PMID: 14641075

5. Methylglyoxal in living organisms: chemistry, biochemistry,

toxicology and biological implications.

<http://www.ncbi.nlm.nih.gov/pubmed/10597025>

Kalapos MP.

Toxicol Lett. 1999 Nov 22;110(3):145-75. Review.

6. Diarrhoea caused by Escherichia coli.

<http://www.ncbi.nlm.nih.gov/pubmed/7687108>

Hart CA, Batt RM, Saunders JR.

Ann Trop Paediatr. 1993;13(2):121-31. Review.

7. Bacterial metabolic 'toxins': A new mechanism for lactose and food

intolerance, and irritable bowel syndrome.

<http://www.ncbi.nlm.nih.gov/pubmed/20851732>

AK, s SB, Vassel N, CD, Naseem R, Chaichi J, Holland

IB, Green J, Wann KT.

Toxicology. 2010 Sep 18.

8. Methylglyoxal impairs the insulin signaling pathways independently of

the formation of intracellular reactive oxygen species.

<http://www.ncbi.nlm.nih.gov/pubmed/16644685>

Riboulet-Chavey A, Pierron A, Durand I, Murdaca J, Giudicelli J, Van

Obberghen E.

Diabetes. 2006 May;55(5):1289-99.

9. Structural and functional changes in human insulin induced by

methylglyoxal. <http://www.ncbi.nlm.nih.gov/pubmed/16723378>

Jia X, Olson DJ, Ross AR, Wu L.

FASEB J. 2006 Jul;20(9):1555-7.

10. Methylglyoxal contributes to the development of insulin resistance

and salt sensitivity in Sprague-Dawley rats.

<http://www.ncbi.nlm.nih.gov/pubmed/19531965>

Guo Q, Mori T, Jiang Y, Hu C, Osaki Y, Yoneki Y, Sun Y, Hosoya T,

Kawamata A, Ogawa S, Nakayama M, Miyata T, Ito S.

J Hypertens. 2009 Aug;27(8):1664-71.