Re: Intestinal Barrier Alterations in Patients With Autism Spectrum Disorders and in Their First-degree Relatives

[Guest guest]

" CONCLUSIONS:: The results obtained support the leaky gut hypothesis and

indicate that measuring IPT could help to identify a subgroup of patients with

autism who could benefit from a gluten-free diet. The IPT alterations found in

first-degree relatives suggest the presence of an intestinal (tight-junction

linked) hereditary factor in the families of subjects with autism. "

Thanks for posting...If I interpret this CONCLUSION correctly, it seems that if

the parents has signs of IBD, and then had a child, the likelihood of that child

having autism due to IBD related conditions is proven? So once again the theory

of " genetics loads the gun, and environment pulls the trigger " prevails? If not,

please explain conclusion to me...This seems like a big deal, and newsworthy!!

Thanks!

Kim

>

> Alterations of the Intestinal Barrier in Patients With Autism Spectrum

> Disorders and in Their First-degree Relatives.

> <http://www.ncbi.nlm.nih.gov/pubmed/20683204>

> de Magistris L et al.

> J Pediatr Gastroenterol Nutr. 2010 Jul 28.

>

> OBJECTIVES:: Intestinal permeability (IPT) was investigated in patients

> with autism as well as in their first-degree relatives to investigate

> leaky gut hypothesis. Faecal calprotectin (FC) was also measured in

> patients with autism, either with or without gastrointestinal symptoms,

> and in their first-degree relatives. PATIENTS AND METHODS:: IPT results,

> assessed by means of the lactulose/mannitol test, were compared with

> adult and child controls and with FC values. RESULTS:: A high percentage

> of abnormal IPT values were found among patients with autism (36.7%) and

> their relatives (21.2%) compared with normal subjects (4.8%). Patients

> with autism on a reported gluten-casein-free diet had significantly

> lower IPT values compared with those who were on an unrestricted diet

> and controls. Gastrointestinal symptoms were present in 46.7% of

> children with autism: constipation (45.5%), diarrhoea (34.1%), and

> others (alternating diarrhoea/constipation, abdominal pain, etc: 15.9%).

> FC was elevated in 24.4% of patients with autism and in 11.6% of their

> relatives; it was not, however, correlated with abnormal IPT values.

> CONCLUSIONS:: The results obtained support the leaky gut hypothesis and

> indicate that measuring IPT could help to identify a subgroup of

> patients with autism who could benefit from a gluten-free diet. The IPT

> alterations found in first-degree relatives suggest the presence of an

> intestinal (tight-junction linked) hereditary factor in the families of

> subjects with autism.

>

>

> */ See also:/*

>

> Inflammatory bowel disease in spouses and their offspring.

> <http://www.ncbi.nlm.nih.gov/pubmed/11231934>

> Laharie D, Debeugny S, Peeters M et al.

> Gastroenterology. 2001 Mar;120(4):816-9.

>

> BACKGROUND & AIMS: The rarity of inflammatory bowel disease (IBD) in

> both husband and wife is often given as an argument against an

> infectious origin. We registered conjugal instances of IBD in Northern

> France and in Belgium between 1989 and 2000. METHODS: Couples were

> assigned to group A if both partners had symptoms of IBD before

> cohabitation, to group B if one spouse had IBD before cohabitation and

> the other experienced first symptoms afterwards, and to group C if both

> partners got the disease after cohabitation. Risk of IBD was assessed in

> their offspring. RESULTS: Thirty conjugal instances were registered.

> Seventeen were concordant for Crohn's disease and 3 for ulcerative

> colitis; 10 were mixed. Two belonged to group A, 6 to group B, and 22 to

> group C. In group C, IBD occurred in the first affected spouse an

> average of 9 years after cohabitation and in the second spouse an

> average of 8.5 years later. Group C conjugal forms were more frequent

> than expected by chance (P < 0.02). Fifty-four children were born to 25

> couples; among them 9, of whom 4 were siblings, developed Crohn's

> disease at a median age of 15 years. CONCLUSIONS: The frequency of

> conjugal forms of IBD suggests an etiologic role for environmental

> factors. Offspring of 2 affected parents have a high risk of developing IBD.

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