myelin in autism: Allergy treatments containing aluminum may cause new allergy, study suggests

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A. Anti-myelin antibodies have been described in autism (a,b; see also

c). In at least some such children, might injected aluminum have been an

etiologically significant factor amid processes leading to anti-myelin

antibodies, especially for individuals with aluminum hypersensitivity

and/or weak alleles which participate in aluminum detoxification

(clearance)?

a. Antibodies to myelin basic protein in children with autistic

behavior. <http://www.ncbi.nlm.nih.gov/pubmed/7682457>

Singh VK, Warren RP, Odell JD, Warren WL, Cole P.

Brain Behav Immun. 1993 Mar;7(1):97-103.

b. Serum anti-myelin-associated glycoprotein antibodies in Egyptian

autistic children. <http://www.ncbi.nlm.nih.gov/pubmed/19073846>

Mostafa GA, El-Sayed ZA, El-Aziz MM, El-Sayed MF.

J Child Neurol. 2008 Dec;23(12):1413-8.

c. Abnormal immune response to brain tissue antigen in the syndrome of

autism. <http://www.ncbi.nlm.nih.gov/pubmed/6182806>

Weizman A, Weizman R, Szekely GA, Wijsenbeek H, Livni E.

Am J Psychiatry. 1982 Nov;139(11):1462-5.

B. Aluminum-sensitivity reactions in humans deliberately injected with

aluminum prompted a preliminary pubmed search:

aluminum AND (myelin[ti] OR gliosis[ti] OR microglia[ti])

Here are results that seem potentially relevant to individuals with

aluminum hypersensitivity and/or weak alleles which participate in

aluminum detoxification (clearance):

1. Oxidative damage in Alzheimer's dementia, and the potential

etiopathogenic role of aluminosilicates, microglia and micronutrient

interactions. <http://www.ncbi.nlm.nih.gov/pubmed/1450585>

PH, Yano E, Klinowski J, hans E.

EXS. 1992;62:178-89. Review.

2. Accumulation of amyloid precursor protein in damaged neuronal

processes and microglia following intracerebral administration of

aluminum salts. <http://www.ncbi.nlm.nih.gov/pubmed/1458313>

Shigematsu K, McGeer PL.

Brain Res. 1992 Oct 9;593(1):117-23

3. Myelin is a preferential target of aluminum-mediated oxidative

damage. <http://www.ncbi.nlm.nih.gov/pubmed/9264541>

Verstraeten SV, Golub MS, Keen CL, Oteiza PI.

Arch Biochem Biophys. 1997 Aug 15;344(2):289-94.

4. Progressive leukoencephalopathy associated with aluminum deposits in

myelin sheath. <http://www.ncbi.nlm.nih.gov/pubmed/18660477>

Itoh M, Suzuki Y, Sugai K, Kozuka N, Ohsawa M, Otsuki T, Goto Y.

J Child Neurol. 2008 Aug;23(8):938-43.

*//*

> Nineteen cases of persistent pruritic nodules and contact allergy to

> aluminium after injection of commonly used aluminium-adsorbed

> vaccines. <http://www.ncbi.nlm.nih.gov/pubmed/16044278>

> Bergfors E, Björkelund C, Trollfors B.

> Eur J Pediatr. 2005 Nov;164(11):691-7

>

> Rare cases of persistent pruritic nodules, sometimes associated with

> aluminium (Al) allergy, have been reported after the use of several Al

> adsorbed vaccines. During vaccine trials in the 1990s a high incidence

> of pruritic nodules (645 cases/76,000 recipients), in 77% associated

> with Al allergy, was observed after the administration of

> diphtheria-tetanus / acellular pertussis (DT/aP) vaccines from a

> single producer. In the present report 19 children with pruritic

> nodules after vaccination with Al hydroxide-adsorbed DTaP/polio+Hib

> (Infanrix, Pentavac) are described. The children had intensely itching

> nodules at the injection site, often aggravated during upper

> respiratory tract infections, and local skin alterations. So far, the

> symptoms have persisted for up to 7 years. The median time between

> vaccination and onset of symptoms was 1 month. 16 children were

> epicutaneously tested for Al, all with positive reactions indicating

> delayed hypersensitivity to Al. The condition is not commonly known

> but is important to recognise, as the child and the family may suffer

> considerably. Future vaccinations with Al-adsorbed vaccines may cause

> aggravation of the symptoms and the Al allergy. Al-containing skin

> products, such as antiperspirants, may cause contact dermatitis.

> Nodules may be mistaken for tumours. Even though the incidence of

> itching nodules and Al allergy after administration of Infanrix,

> Pentavac and other Al-adsorbed vaccines is probably low, research to

> replace Al adjuvants seems appropriate. We conclude that intensely

> itching subcutaneous nodules, lasting for many years, and

> hypersensitivity to aluminium may occur after DTaP/polio+Hib

> vaccination of infants.

>

> */Allergy Treatments Containing Aluminum May Cause New Allergy, Study

> Suggests /*

>

> ScienceDaily (Dec. 15, 2010) --- Allergic contact dermatitis from

> aluminium has previously been considered very unusual. However, there

> are now reports of pruritic nodules and aluminium allergy arising

> after vaccinations or treatments for allergies. Researcher Eva

> Netterlid has studied the problem in a thesis recently defended at

> Lund University in Sweden...

> http://www.sciencedaily.com/releases/2010/12/101214085545.htm