MB-12 rodent study

[Guest guest]

A study just came out about the methylcobalamin form of Vit B12, concerning

possible toxicity of the cobalt element. This is Dr. Jim Neubrander's reply:

That this article and content was to be published was nothing new to me because

it first came to my attention when the Geirs presented their theory at Cherry

Hill a year ago. I lecture to physicians about the flaws in this study when

doing training seminars. A full discussion would take an hour or more to write

so I will only list a few key points here. It is the cobalt inorganic salts

that are toxic, not the organic form of cobalt that is bound on all four binding

sites in the corrin ring. The more we take of B12 by any route of

administration, the more that passes unchanged from the blood to the urine. If

one did not find it to be high in the urine, then that would indicate a problem.

Laboratories do not differentiate between organic and inorganic amounts of

cobalt but report the total amount of cobalt present along with a reference

range that was created for the inorganic toxic form for miners and " old

fashioned beers " (no longer used). An

analogy would be to consider the total number of eggs one will be adding to a

cake mix before and after it is baked and then try to compare the taste and

texture of eggs to a cake. As an environmental physician, we see fairly rapid

cause and effect for truly toxic agents, only one of which are heavy metals or

metals in general. The effects of mercury or lead or arsenic are just as rapid

and severe after exposure as are the effects from toxic amounts of poisonous

chemicals. Therefore, common sense dictates that from the thousands of children

I have treated, added to that the tens of thousands of children who have now

been treated worldwide, if there really was a problem we would have seen it by

now and that the effects would be pronounced. Exactly the opposite is what we

as clinicians and parents see to be the case. Add to that incredible amount of

clinical data that has and continues to be accumulated the fact that other

published " clinical "

studies (not quoted in the Geir article) support the fact that higher doses are

safe and possibly more effective than lower doses. All of that should be taken

into account and weighed against the findings of the recent 2010 Okada rat

study. In that study whereby rat's nerves were transected, they found that the

methyl analog of the B12 family was significantly more biologically active than

any other form of B12. They also documented that it is the shortest lived

analog and therefore clinicians should consider giving it by injections instead

of the usual routes of administration. In addition, they found the greatest

benefits at high to very high doses. What occurred in the rat's nervous tissue

under these conditions (organic cobalt plus the cobalamin molecule) was that it

increased the length of axons, increased formation of neurites, increased

resistance to apoptosis, was involved in kinase signaling pathways, and helped

repair the transected

nerves. Therefore, what you do with " this study " is up to you but " published

studies show " that mercury and vaccines are safe and not related to the autism

epidemic. Many other " published studies " have proven many things we believe to

not be true but are passed along as fact. Therefore, the final thing that any

parent has to do, you just being one of them, is to decide for yourself what you

choose to believe and after that follow your heart. I have no qualms with that.

However, as for me, after observing thousands of my own patients do so well on

injectable MB12, and where the majority of them do even better with daily shots

than every two or three day shots, I can confidently say I've read the study and

do not agree with its implications or conclusions other than the statement that

is " politically correct " to state in all publications -- " we need more studies! "

I agree. However, we also need more kids being able to partake of a powerful

treatment as one major tool on their road to recovery. With that I cast my

vote with MB12.

Sincerely, Jim Neubrander, M.D

ps I'm voting with Jim Neubrander. Dr. JM

[Guest guest]

SO it would be correct to add organic cobalt together with MB-12 inj.

administrated for our children? 

 

THank you

 

Elena 

Subject: MB-12 rodent study

To: " csb-autism-rx " <csb-autism-rx >

Date: Monday, May 3, 2010, 3:44 AM

 

A study just came out about the methylcobalamin form of Vit B12, concerning

possible toxicity of the cobalt element. This is Dr. Jim Neubrander's reply:

That this article and content was to be published was nothing new to me because

it first came to my attention when the Geirs presented their theory at Cherry

Hill a year ago. I lecture to physicians about the flaws in this study when

doing training seminars. A full discussion would take an hour or more to write

so I will only list a few key points here. It is the cobalt inorganic salts that

are toxic, not the organic form of cobalt that is bound on all four binding

sites in the corrin ring. The more we take of B12 by any route of

administration, the more that passes unchanged from the blood to the urine. If

one did not find it to be high in the urine, then that would indicate a problem.

Laboratories do not differentiate between organic and inorganic amounts of

cobalt but report the total amount of cobalt present along with a reference

range that was created for the inorganic toxic form for miners and " old

fashioned beers " (no longer used). An

analogy would be to consider the total number of eggs one will be adding to a

cake mix before and after it is baked and then try to compare the taste and

texture of eggs to a cake. As an environmental physician, we see fairly rapid

cause and effect for truly toxic agents, only one of which are heavy metals or

metals in general. The effects of mercury or lead or arsenic are just as rapid

and severe after exposure as are the effects from toxic amounts of poisonous

chemicals. Therefore, common sense dictates that from the thousands of children

I have treated, added to that the tens of thousands of children who have now

been treated worldwide, if there really was a problem we would have seen it by

now and that the effects would be pronounced. Exactly the opposite is what we as

clinicians and parents see to be the case. Add to that incredible amount of

clinical data that has and continues to be accumulated the fact that other

published " clinical "

studies (not quoted in the Geir article) support the fact that higher doses are

safe and possibly more effective than lower doses. All of that should be taken

into account and weighed against the findings of the recent 2010 Okada rat

study. In that study whereby rat's nerves were transected, they found that the

methyl analog of the B12 family was significantly more biologically active than

any other form of B12. They also documented that it is the shortest lived analog

and therefore clinicians should consider giving it by injections instead of the

usual routes of administration. In addition, they found the greatest benefits at

high to very high doses. What occurred in the rat's nervous tissue under these

conditions (organic cobalt plus the cobalamin molecule) was that it increased

the length of axons, increased formation of neurites, increased resistance to

apoptosis, was involved in kinase signaling pathways, and helped repair the

transected

nerves. Therefore, what you do with " this study " is up to you but " published

studies show " that mercury and vaccines are safe and not related to the autism

epidemic. Many other " published studies " have proven many things we believe to

not be true but are passed along as fact. Therefore, the final thing that any

parent has to do, you just being one of them, is to decide for yourself what you

choose to believe and after that follow your heart. I have no qualms with that.

However, as for me, after observing thousands of my own patients do so well on

injectable MB12, and where the majority of them do even better with daily shots

than every two or three day shots, I can confidently say I've read the study and

do not agree with its implications or conclusions other than the statement that

is " politically correct " to state in all publications -- " we need more studies! "

I agree. However, we also need more kids being able to partake of a powerful

treatment as one major tool on their road to recovery. With that I cast my vote

with MB12.

Sincerely, Jim Neubrander, M.D

ps I'm voting with Jim Neubrander. Dr. JM

[Guest guest]

I do not plan to add, subtract or change anything based on this study, and the

dann docs are discussing it right now.  I will let the group know if there is a

consensus or any change in our current protocol recommendations.  Dr. JM 

From: JAQUELYN MCCANDLESS <JMcCandless@ prodigy.net>

Subject: [csb-autism- rx] MB-12 rodent study

To: " csb-autism-rx@ yahoogroups. com " <csb-autism-rx@ yahoogroups. com>

Date: Monday, May 3, 2010, 3:44 AM

 

A study just came out about the methylcobalamin form of Vit B12, concerning

possible toxicity of the cobalt element. This is Dr. Jim Neubrander's reply:

That this article and content was to be published was nothing new to me because

it first came to my attention when the Geirs presented their theory at Cherry

Hill a year ago. I lecture to physicians about the flaws in this study when

doing training seminars. A full discussion would take an hour or more to write

so I will only list a few key points here. It is the cobalt inorganic salts that

are toxic, not the organic form of cobalt that is bound on all four binding

sites in the corrin ring. The more we take of B12 by any route of

administration, the more that passes unchanged from the blood to the urine. If

one did not find it to be high in the urine, then that would indicate a problem.

Laboratories do not differentiate between organic and inorganic amounts of

cobalt but report the total amount of cobalt present along with a reference

range that was created for the inorganic toxic form for miners and " old

fashioned beers " (no longer used). An

analogy would be to consider the total number of eggs one will be adding to a

cake mix before and after it is baked and then try to compare the taste and

texture of eggs to a cake. As an environmental physician, we see fairly rapid

cause and effect for truly toxic agents, only one of which are heavy metals or

metals in general. The effects of mercury or lead or arsenic are just as rapid

and severe after exposure as are the effects from toxic amounts of poisonous

chemicals. Therefore, common sense dictates that from the thousands of children

I have treated, added to that the tens of thousands of children who have now

been treated worldwide, if there really was a problem we would have seen it by

now and that the effects would be pronounced. Exactly the opposite is what we as

clinicians and parents see to be the case. Add to that incredible amount of

clinical data that has and continues to be accumulated the fact that other

published " clinical "

studies (not quoted in the Geir article) support the fact that higher doses are

safe and possibly more effective than lower doses. All of that should be taken

into account and weighed against the findings of the recent 2010 Okada rat

study. In that study whereby rat's nerves were transected, they found that the

methyl analog of the B12 family was significantly more biologically active than

any other form of B12. They also documented that it is the shortest lived analog

and therefore clinicians should consider giving it by injections instead of the

usual routes of administration. In addition, they found the greatest benefits at

high to very high doses. What occurred in the rat's nervous tissue under these

conditions (organic cobalt plus the cobalamin molecule) was that it increased

the length of axons, increased formation of neurites, increased resistance to

apoptosis, was involved in kinase signaling pathways, and helped repair the

transected

nerves. Therefore, what you do with " this study " is up to you but " published

studies show " that mercury and vaccines are safe and not related to the autism

epidemic. Many other " published studies " have proven many things we believe to

not be true but are passed along as fact. Therefore, the final thing that any

parent has to do, you just being one of them, is to decide for yourself what you

choose to believe and after that follow your heart. I have no qualms with that.

However, as for me, after observing thousands of my own patients do so well on

injectable MB12, and where the majority of them do even better with daily shots

than every two or three day shots, I can confidently say I've read the study and

do not agree with its implications or conclusions other than the statement that

is " politically correct " to state in all publications -- " we need more studies! "

I agree. However, we also need more kids being able to partake of a powerful

treatment as one major tool on their road to recovery. With that I cast my vote

with MB12.

Sincerely, Jim Neubrander, M.D

ps I'm voting with Jim Neubrander. Dr. JM

[Guest guest]

Dr. JM, do we have permission to copy Dr. Neubrander's reply to the Methyl B-12

article and post it to other groups? Several local moms in another group I am

on are concerned, and I would like to share his response.

Thanks,

Yerly

Austin, TX

[Guest guest]

http://www.ageofautism.com/2010/05/critical-response-to-study-of-mb12-injections\

..html

>

>

>

> Subject: MB-12 rodent study

> To: " csb-autism-rx " <csb-autism-rx >

> Date: Monday, May 3, 2010, 3:44 AM

>

>

>  

>

>

>

> A study just came out about the methylcobalamin form of Vit B12, concerning

possible toxicity of the cobalt element. This is Dr. Jim Neubrander's reply:

>

> That this article and content was to be published was nothing new to me

because it first came to my attention when the Geirs presented their theory at

Cherry Hill a year ago. I lecture to physicians about the flaws in this study

when doing training seminars. A full discussion would take an hour or more to

write so I will only list a few key points here. It is the cobalt inorganic

salts that are toxic, not the organic form of cobalt that is bound on all four

binding sites in the corrin ring. The more we take of B12 by any route of

administration, the more that passes unchanged from the blood to the urine. If

one did not find it to be high in the urine, then that would indicate a problem.

Laboratories do not differentiate between organic and inorganic amounts of

cobalt but report the total amount of cobalt present along with a reference

range that was created for the inorganic toxic form for miners and " old

fashioned beers " (no longer used). An

> analogy would be to consider the total number of eggs one will be adding to a

cake mix before and after it is baked and then try to compare the taste and

texture of eggs to a cake. As an environmental physician, we see fairly rapid

cause and effect for truly toxic agents, only one of which are heavy metals or

metals in general. The effects of mercury or lead or arsenic are just as rapid

and severe after exposure as are the effects from toxic amounts of poisonous

chemicals. Therefore, common sense dictates that from the thousands of children

I have treated, added to that the tens of thousands of children who have now

been treated worldwide, if there really was a problem we would have seen it by

now and that the effects would be pronounced. Exactly the opposite is what we as

clinicians and parents see to be the case. Add to that incredible amount of

clinical data that has and continues to be accumulated the fact that other

published " clinical "

> studies (not quoted in the Geir article) support the fact that higher doses

are safe and possibly more effective than lower doses. All of that should be

taken into account and weighed against the findings of the recent 2010 Okada rat

study. In that study whereby rat's nerves were transected, they found that the

methyl analog of the B12 family was significantly more biologically active than

any other form of B12. They also documented that it is the shortest lived analog

and therefore clinicians should consider giving it by injections instead of the

usual routes of administration. In addition, they found the greatest benefits at

high to very high doses. What occurred in the rat's nervous tissue under these

conditions (organic cobalt plus the cobalamin molecule) was that it increased

the length of axons, increased formation of neurites, increased resistance to

apoptosis, was involved in kinase signaling pathways, and helped repair the

transected

> nerves. Therefore, what you do with " this study " is up to you but " published

studies show " that mercury and vaccines are safe and not related to the autism

epidemic. Many other " published studies " have proven many things we believe to

not be true but are passed along as fact. Therefore, the final thing that any

parent has to do, you just being one of them, is to decide for yourself what you

choose to believe and after that follow your heart. I have no qualms with that.

However, as for me, after observing thousands of my own patients do so well on

injectable MB12, and where the majority of them do even better with daily shots

than every two or three day shots, I can confidently say I've read the study and

do not agree with its implications or conclusions other than the statement that

is " politically correct " to state in all publications -- " we need more studies! "

I agree. However, we also need more kids being able to partake of a powerful

> treatment as one major tool on their road to recovery. With that I cast my

vote with MB12.

> Sincerely, Jim Neubrander, M.D

>

> ps I'm voting with Jim Neubrander. Dr. JM

>

>

>

>

>

>

>

>

>

>

>

>