autism, HMGB1, glutamate

[Guest guest]

A preliminary miscellany about HMGB1, plus a few glutamate/autism citations

Increased serum levels of high mobility group box 1 protein in patients

with autistic disorder. <http://www.ncbi.nlm.nih.gov/pubmed/20302902>

Emanuele E, Boso M, Brondino N, Pietra S, Barale F, di Nemi SU, Politi P.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 16. [Epub ahead of

print]

Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1

from cortical astrocytes. <http://www.ncbi.nlm.nih.gov/pubmed/20222144>

Hayakawa K, Arai K, Lo EH.

Glia. 2010 Mar 10. [Epub ahead of print]

RAGE-independent autoreactive B cell activation in response to chromatin

and HMGB1/DNA immune complexes.

<http://www.ncbi.nlm.nih.gov/pubmed/20014975>

Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ,

Marshak-Rothstein A.

Autoimmunity. 2010 Feb;43(1):103-10.

RAGE-independent autoreactive B cell activation in response to chromatin

and HMGB1/DNA immune complexes.

<http://www.ncbi.nlm.nih.gov/pubmed/20014975>

Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ,

Marshak-Rothstein A.

Autoimmunity. 2010 Feb;43(1):103-10.

HMGB1 loves company. <http://www.ncbi.nlm.nih.gov/pubmed/19414536>

Bianchi ME.

J Leukoc Biol. 2009 Sep;86(3):573-6.

Native HMGB1 protein inhibits repair of cisplatin-damaged nucleosomes in

vitro. <http://www.ncbi.nlm.nih.gov/pubmed/19401149>

Ugrinova I, Zlateva S, Pashev IG, Pasheva EA.

Int J Biochem Cell Biol. 2009 Jul;41(7):1556-62.

Chromatin-specific remodeling by HMGB1 and linker histone H1 silences

proinflammatory genes during endotoxin tolerance.

<http://www.ncbi.nlm.nih.gov/pubmed/19158276>

El Gazzar M, Yoza BK, Chen X, BA, Young NL, McCall CE.

Mol Cell Biol. 2009 Apr;29(7):1959-71.

Induction of inflammatory and immune responses by HMGB1-nucleosome

complexes: implications for the pathogenesis of SLE.

<http://www.ncbi.nlm.nih.gov/pubmed/19064698>

Urbonaviciute V, Fürnrohr BG, Meister S, Munoz L, Heyder P, De Marchis

F, Bianchi ME, Kirschning C, Wagner H, Manfredi AA, Kalden JR, Schett G,

Rovere-Querini P, Herrmann M, Voll RE.

J Exp Med. 2008 Dec 22;205(13):3007-18.

High mobility group box 1 in the pathogenesis of inflammatory and

autoimmune diseases. <http://www.ncbi.nlm.nih.gov/pubmed/18300566>

Voll RE, Urbonaviciute V, Herrmann M, Kalden JR.

Isr Med Assoc J. 2008 Jan;10(1):26-8. Review.

High mobility group protein B1 enhances DNA repair and chromatin

modification after DNA damage. <http://www.ncbi.nlm.nih.gov/pubmed/18650382>

Lange SS, DL, Vasquez KM.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10320-5.

The anti-inflammatory effects of heat shock protein 72 involve

inhibition of high-mobility-group box 1 release and proinflammatory

function in macrophages. <http://www.ncbi.nlm.nih.gov/pubmed/17617616>

Tang D, Kang R, Xiao W, Wang H, Calderwood SK, Xiao X.

J Immunol. 2007 Jul 15;179(2):1236-44.

Hydrogen peroxide stimulates macrophages and monocytes to actively

release HMGB1. <http://www.ncbi.nlm.nih.gov/pubmed/17135572>

Tang D, Shi Y, Kang R, Li T, Xiao W, Wang H, Xiao X.

J Leukoc Biol. 2007 Mar;81(3):741-7.

Conformational difference in HMGB1 proteins of human neutrophils and

lymphocytes revealed by epitope mapping of a monoclonal antibody.

<http://www.ncbi.nlm.nih.gov/pubmed/15496585>

Ito I, Mitsuoka N, Sobajima J, Uesugi H, Ozaki S, Ohya K, Yoshida M.

J Biochem. 2004 Aug;136(2):155-62.

Nucleosome remodeling: one mechanism, many phenomena?

<http://www.ncbi.nlm.nih.gov/pubmed/15020046>

Längst G, Becker PB.

Biochim Biophys Acta. 2004 Mar 15;1677(1-3):58-63

ATP-dependent chromatin structural modulation by multiprotein complex

including HMGB1. <http://www.ncbi.nlm.nih.gov/pubmed/14999020>

Yamada M, Ueda T, Sato K, Yoshida M.

J Biochem. 2004 Jan;135(1):149-53.

*The search autism AND glutamate generated 144 citations*

*eg*

Urinary metabolic phenotyping differentiates children with autism, from

their unaffected siblings and age-matched controls.

<http://www.ncbi.nlm.nih.gov/pubmed/20337404>

Yap IK, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK.

J Proteome Res. 2010 Mar 25. [Epub ahead of print]

Increased serum levels of high mobility group box 1 protein in patients

with autistic disorder. <http://www.ncbi.nlm.nih.gov/pubmed/20302902>

Emanuele E, Boso M, Brondino N, Pietra S, Barale F, di Nemi SU, Politi P.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 16. [Epub ahead of

print]

Novel and emerging treatments for autism spectrum disorders: a

systematic review. <http://www.ncbi.nlm.nih.gov/pubmed/19917212>

Rossignol DA.

Ann Clin Psychiatry. 2009 Oct-Dec;21(4):213-36. Review.

Immune-glutamatergic dysfunction as a central mechanism of the autism

spectrum disorders. <http://www.ncbi.nlm.nih.gov/pubmed/19149568>

Blaylock RL, Strunecka A.

Curr Med Chem. 2009;16(2):157-70. Review.

A possible central mechanism in autism spectrum disorders, part 1.

<http://www.ncbi.nlm.nih.gov/pubmed/19043938>

Blaylock RL.

Altern Ther Health Med. 2008 Nov-Dec;14(6):46-53. Review.

A possible central mechanism in autism spectrum disorders, part 2:

immunoexcitotoxicity. <http://www.ncbi.nlm.nih.gov/pubmed/19161050>

Blaylock RL.

Altern Ther Health Med. 2009 Jan-Feb;15(1):60-7.

A possible central mechanism in autism spectrum disorders, part 3: the

role of excitotoxin food additives and the synergistic effects of other

environmental toxins. <http://www.ncbi.nlm.nih.gov/pubmed/19284184>

Blaylock RL.

Altern Ther Health Med. 2009 Mar-Apr;15(2):56-60.