Vitamin C - chlorpyrifos - organophosphates - PON1 alleles - autism

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Ameliorative effect of vitamin C on chlorpyrifos-induced erythrocyte

osmotic fragility in Wistar rats.

<http://www.ncbi.nlm.nih.gov/pubmed/20378658>

Ambali SF, Ayo JO, Ojo SA, Esievo KA.

Hum Exp Toxicol. 2010 Apr 8. [Epub ahead of print]

Chlorpyrifos is a crystalline organophosphate insecticide that inhibits

acetylcholinesterase and is used to control insect pests. Trade names

include Brodan ...

http://en.wikipedia.org/wiki/Chlorpyrifos

Paraoxonase gene variants are associated with autism in North America,

but not in Italy: possible regional specificity in gene-environment

interactions. <http://www.ncbi.nlm.nih.gov/pubmed/16027737>

D'Amelio M et al.

Mol Psychiatry. 2005 Nov;10(11):1006-16.

" Organophosphates (OPs) are routinely used as pesticides in agriculture

and as insecticides within the household. Our prior work on Reelin and

APOE delineated a gene-environment interactive model of autism

pathogenesis, whereby genetically vulnerable individuals prenatally

exposed to OPs during critical periods in neurodevelopment could undergo

altered neuronal migration, resulting in an autistic syndrome. Since

household use of OPs is far greater in the USA than in Italy... These

results are consistent with our model and provide further support for

the hypothesis that concurrent genetic vulnerability and environmental

OP exposure may possibly contribute to autism pathogenesis in a sizable

subgroup of North American individuals.

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