RE: Valtrex and bonemarrow suppression

[Guest guest]

Are you sure the suppression she mentioned isn't due to chelation?

I couldn't find one thing on pubmed about Valtrex. It and other antivirals

are used in patients that have had bone marrow and organ transplantation to

suppress the herpesviruses that activate. If it suppressed bone marrow it

wouldn't make sense to use something that's going to suppress the cells you

transplanted.

----Original Message Follows----

From: " worryfree97 " <worryfree97@...>

Reply-

Subject: Valtrex and bonemarrow suppression

Date: Thu, 05 Aug 2004 16:14:20 -0000

We have been on Dr G's protocol for viral/immune issues for over 1.5

years. Our son has been on Valtrex, Diflucan, IMGG. We have also

taken advice from other experts from time to time who have expertise

in immune related issues. We contacted Dr Harumi Jyonouchi who is

doing cutting edge immune research in cytokines and TNF.

Her office tells me that some of Dr G's patients, who have gone to

Dr Yanouchi, have had adverse reactions to Valtrex as this could be

bone marrow suppressive. Dr janouchi is against Dr G's protocol of

using Valtrex.

This information needs to be further investigated as I have not yet

talked with Dr G or Dr Janouchi. But some of Dr G's patients going

to Dr Janouchi with adverse effects from Valtrex appears to be true.

We are very concerned about effect of Valtrex on bone marrow.

Has anyone done any research on this and please explain to me.

Regards,

AJ

Responsibility for the content of this message lies strictly with

the original author(s), and is not necessarily endorsed by or the

opinion of the Research Institute.

[Guest guest]

I'm not sure if this is what you're looking for, but these two sites have

charts that overview blood abnormalities during trials of Valtrex in patients

with various viruses. One in particular, Herpes Zoster, shows a higher

incidence

of abnormal white blood cell counts with the Valtrex treated people versus

placebo.

Gaylen

Click here: Valtrex Side Effects, Interactions, Reactions, Pediatric,

Geriatric - Valacyclovir

Click here: Valtrex Caplets Drug Information Valtrex Caplets

[Guest guest]

Oops, try these links to get to the charts I mentioned about abnormal white

blood cell counts:

http://www.rxlist.com/cgi/generic3/valacyclovir_ad.htm

http://www.drugs.com/PDR/Valtrex_Caplets.html

[Guest guest]

The literature in the UK (Glaxo -Wellcome) manufactured Valtrex package

says:

" Valaciclovir is rapidly and almost completely converted in man to aciclovir

and valine, probably by the enzyme referred to as valaciclovir hydrolase.

Aciclovir is a specific inhibitor of the herpes viruses with in vitro

activity against herpes simplex viruses (HSV) type 1 and type 2, varicella

zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr Virus (EBV), and

human herpes virus 6 (HHV-6). "

it goes on to say

" Extensive monitoring of clinical isolates from patients receiving aciclovir

therapy or prophylaxis has revealed that the virus with reduced sensitivity

to aciclovir is extremely rare in the immunocompetent and is only found

infrequently in severely immunocompromised individuals e.g. solid organ or

bone marrow recipients, patients receiving chemotherapy for malignant

disease and people infected with the human immunodeficiancy virus (HIV). "

Re: Valtrex and bonemarrow suppression

VALTREX™

Valacyclovir or VALTREX is an orally delivered drug chiefly used to

treat HSV and VZV. It is a prodrug of acylovir, meaning that it is

converted to active acyclovir within the body. This results in

higher levels of drug in the blood stream and it is believed that

this level of drug might be partially effective against HHV-6.

**** Valcyclovir has been used to effectively decrease the incidence of

HHV-6 associated disease in bone marrow transplant recipients.****

Thus it is effective against reactivation of HHV-6, but may not be

effective in suppressing an active, chronic infection. Studies have

also demonstrated that VALTREX therapy at standard dosages is

associated with a low rate of adverse side effects.

Thus, VALTREX treatment stands as a potential alternative for long-

term therapy for HHV-6 associated diseases, especially in

combination with another antiviral drugs such as beta interferon.

SOURCE ::

http://www.ivpresearch.org/drugs.htm

Responsibility for the content of this message lies strictly with

the original author(s), and is not necessarily endorsed by or the

opinion of the Research Institute.

[Guest guest]

Kathy

The links that you sent did not come through. I will surf for the info but

if I do not find it please resend the links

Bill

Re: Valtrex and bonemarrow suppression

I'm not sure if this is what you're looking for, but these two sites have

charts that overview blood abnormalities during trials of Valtrex in

patients

with various viruses. One in particular, Herpes Zoster, shows a higher

incidence

of abnormal white blood cell counts with the Valtrex treated people versus

placebo.

Gaylen

Click here: Valtrex Side Effects, Interactions, Reactions, Pediatric,

Geriatric - Valacyclovir

Click here: Valtrex Caplets Drug Information Valtrex Caplets