human herpesvirus-6

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1-Potential screening assay for undetectable viruses on the basis of their

capacity to induce alpha interferon production.

2-Bilateral optic neuropathy and unilateral tonic pupil associated with

acute human herpesvirus 6 infection: a case report.

3-Atypical clinical features of a human herpesvirus-6 infection in a

neonate.

4-Human herpesvirus 6 infects the central nervous system of multiple

sclerosis patients in the early stages of the disease.

5-Facial nerve palsy after human herpesvirus 6 infection.

6-Syndrome of inappropriate secretion of antidiuretic hormone as a

complication of human herpesvirus-6 infection. No abstract available

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J Clin Microbiol. 2004 Sep;42(9):4300-2.

Potential screening assay for undetectable viruses on the basis of their

capacity to induce alpha interferon production.

Schmidt B, Ashlock B, Neipel F, Levy JA.

Department of Medicine, Division of Hematology/Oncology, University of

California School of Medicine, San Francisco, CA 94143-1270, USA.

High interferon production by plasmacytoid dendritic cells (PDC) was

unexpectedly noted after their coculture with CD4(+) cells from a healthy

donor whose cells subsequently showed human herpesvirus type 6 and 7

infections.

This release of interferon was not observed with uninfected normal CD4(+)

cells.

Induction of PDC interferon production could help screen for covert virus

infections.

PMID: 15365027 [PubMed - in process]

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Graefes Arch Clin Exp Ophthalmol. 2004 Sep 10 [Epub ahead of print]

Bilateral optic neuropathy and unilateral tonic pupil associated with acute

human herpesvirus 6 infection: a case report.

Oberacher-Velten IM, Jonas JB, Junemann A, Schmidt B.

Department of Ophthalmology and University Eye Hospital, University of

Erlangen-Nurnberg, Schwabachanlage 6, 91054, Erlangen, Germany.

BACKGROUND. Human herpesvirus 6 (HHV-6), a widespread virus and causative

agent of exanthema subitum in children, has been associated with a number of

neurologic disorders including cranial nerve palsies, seizures,

encephalitis, meningitis, and multiple sclerosis.

PATIENT. A 31-year-old man presented with bilateral optic neuropathy, disc

edema, and unilateral tonic pupil, which were found to be associated with

acute HHV-6 infection. The patient had been suffering from juvenile diabetes

for 5 years. One week after onset of intravenous antiviral therapy with

foscarnet, disc edema subsided, and tonic pupil reaction was no longer

detectable.

CONCLUSIONS. HHV-6 infection may play a role as a causative agent in

patients with optic neuropathy and tonic pupil.

PMID: 15365853 [PubMed - as supplied by publisher]

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J Med Virol. 2004 Nov;74(3):463-6.

Atypical clinical features of a human herpesvirus-6 infection in a neonate.

Yoshikawa T, Suzuki K, Umemura K, Akimoto S, Miyake F, Usui C, Fujita A,

Suga S, Asano Y.

Department of Pediatrics, Fujita Health University School of Medicine,

Toyoake, Aichi, Japan. tetsushi@...

A case of neonatal human herpesvirus 6 (HHV-6) B infection is presented.

Although HHV-6 B was isolated from peripheral blood at the onset of the

illness, a significant increase in viral antibody titers was not observed.

The patient had a slight fever with generalized maculopapular skin rash and

an increased number of atypical lymphocytes, which is quite different from

the typical clinical features of exanthem subitum.

PMID: 15368515 [PubMed - in process]

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Mult Scler. 2004 Aug;10(4):348-54.

Human herpesvirus 6 infects the central nervous system of multiple sclerosis

patients in the early stages of the disease.

Rotola A, Merlotti I, Caniatti L, Caselli E, Granieri E, Tola MR, Di Luca D,

Cassai E.

Section of Microbiology, Department of Experimental and Diagnostic Medicine,

University of Ferrara, Italy.

The presence and the replicative state of human herpesvirus 6 (HHV-6) were

evaluated in clinical samples from multiple sclerosis (MS) patients at the

first time of MS diagnosis. HHV-6 variant B was present in peripheral blood

mononuclear cells of 5/32 (15%) patients, but persisted with a latent

infection.

Viral sequences were present also in cerebrospinal fluid (CSF), both free in

the liquid (7/32, 22%) and latent in the cellular fraction (3/32, 9%), as

shown by analysis of viral transcription. In these cases, variant A was

detected. HHV-6 DNA sequences present in the CSF were associated to mature

viral particles. In fact, in vitro infectious assays of CSF showed the

presence of replication-competent virions.

These results show that about 20% of MS patients have active foci of HHV-6

variant A infection in the early stages of the disease and suggest that

viral replication takes place within the central nervous system.

PMID: 15327028 [PubMed - in process]

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Pediatr Infect Dis J. 2004 Jul;23(7):688-9.

Facial nerve palsy after human herpesvirus 6 infection.

Pitkaranta A, Lahdenne P, Piiparinen H.

Department of Otorhinolaryngology, Helsinki University Central Hospital,

Helsinki, Finland. anne.pitkaranta@...

Facial nerve palsy has long been considered to have an infectious etiology,

either viruses, mainly herpesviruses, or bacteria, such as Borrelia

burgdorferi.

We report for the first time the association of human herpesvirus 6 and

facial palsy in a previously healthy 1-year 9-month-old boy who developed

left facial nerve palsy 7 days after exanthema subitum caused by human

herpesvirus 6.

Publication Types:

Case Reports

PMID: 15247617 [PubMed - indexed for MEDLINE]

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Shimura N, Kim H, Sugimoto H, Aoyagi Y, Baba H, Kim S. Related Articles,

Links

Syndrome of inappropriate secretion of antidiuretic hormone as a

complication of human herpesvirus-6 infection.

Pediatr Int. 2004 Aug;46(4):497-8. No abstract available.

PMID: 15310326 [PubMed - in process

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