RE: anti-viral response

[Guest guest]

Jane,

If it helps, I have found similar results with my son's antivirals. He was

on valtrex for almost eight months and I was more impressed with the results

from his antifungal and diet than the valtrex. After eight months, his HHV6

came up only to 10 which is almost normal, starting from normal range initially.

We've since changed to famvir, only on it for a few months and dying to see

a new HHV6. Overall, we have seen language improvement and fine motor

improvement since he started the protocol and he was also " high functioning " to

begin

with. Hope this helps.

Amy

[Guest guest]

Susi,

I don't have dosing information, though sometimes Dr G might prescribe

anti - viral 3 x per day as an additional dose for a period when the usual

is 2.

While the US package insert or drug literature for Valtrex doesn't seem to

mention its effectiveness against EBV, CMV and HHV 6, the package

manufactured in the UK does...

UK literature in the Valtrex pack says:

" Valaciclovir is rapidly and almost completely converted in man to aciclovir

and valine, probably by the enzyme referred to as valaciclovir hydrolase.

Aciclovir is a specific inhibitor of the herpes viruses with in vitro

activity against herpes simplex viruses (HSV) type 1 and type 2, varicella

zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr Virus (EBV), and

human herpes virus 6 (HHV-6). Aciclovir inhibits herpes virus DNA synthesis

once it has been phosphorylated to the active triphosphate form. The first

stage of phosphorylation requires the activity of a virus-specific enzyme.

In the case of HSV, VZV and EBV, this enzyme is the viral thymidine kinase

(TK), which is only present in virus infected cells. Selectivity is

maintained in CMV with phosphorylation, at least in part, being mediated

through the phosphotransferase gene product of UL97. This requirement for

activation of aciclovir by a virus specific enzyme largely explains its

selectivity. ....etc etc.... Extensive monitoring of clinical isolates from

patients receiving aciclovir therapy or prophylaxis has revealed that the

virus with reduced sensitivity to aciclovir is extremely rare in the

immunocompetent and is only found infrequently in severely immunocompromised

individuals e.g. solid organ or bone marrow recipients, patients receiving

chemotherapy for malignant disease and people infected with the human

immunodeficiancy virus (HIV). "

Both are manufactured by GSK

Hope this helps you

Re: anti-viral response

Hi,

We are trying to follow portions of the protocol best we can on our

own. My daughter's immune panel showed elevated levels of HHV6 and I was

able to convince her pediatrician to give her a prescription of Valtrex. He

said he could find no reference to give her more than 500mg twice a day but

I've seen it mentioned elsewhere that larger children need 500mg 3 times a

day. She's 12 and weighs 103 pounds. Can anyone tell me what dosage Dr.

Goldberg recommends AND if there is any study/info to back it up that I can

show her doctor?

One other question. From reading this list, I know there are others out

there trying to implement the protocol with help from doctors not

trained in the method. Where do you find your information? I have 2

doctors willing to do anything to help my daughter but I can't find the

right person to put them in contact with. Any ideas?

Susi

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