Alternating Electrical Fields

[Guest guest]

Dr. Bormann,

Thank you for posting this link. This a continuation of work done a few

years ago by the same group. This article expands on their work and

provides some very useful information!

Their initial work with mice a few years ago implanted electrodes, and used

frequencies in the 100 to 200 KHz ranges for treatment.This study uses

frequencies in the same ranges but now uses external adhesive electrodes.

This study lists some specific frequencies which should be of great use to

us in the Rife community. they found optimal frequencies for treatment of

different types of cancer. I've excerpted these and reworked the sentence

structre a bit to clarify.

>It is seen that the optimal frequency is:

>100 kHz for mouse melanoma (B16F1),

>150 kHz for human breast carcinoma (MDA-MB-231),

>200 kHz for rat glioma (F-98).

>In addition,

>similar experiments were performed in two human glioma cell

>lines (U-118 and U-87). In both, the optimal TTFields frequency

>was identical to rat glioma cell lines (i.e., 200 kHz).

The next item of interest to us has to do with the field intensity.

> It is seen that effect on cell division and cell death (by apoptosis) is

>intensity dependent, the sensitivity being highest for mouse melanoma

>cells, >decreasing for rat glioma and for human non-small-cell lung

>carcinoma and >lowest for human breast carcinoma.

The graph of field intensity shows a range of between roughly 1.4 and 3.0

V/cm is used for treatment.

GBM treatment was via external electrodes in an array of 22.5 square cm.

The frequencies were used for between 16 to 18 hours a day. Output of the

frequency generator to the electrode array was just less than 31ma, and

voltage was 42V.

The last very important finding applies to those people using electrode

type devices in high frequency ranges. The type of electrode used was found

to be critical in obtaining effects. Alternating currents are subject to a

problem known as reactance. This is just another way of saying resistance.

The resistance goes up with increases in frequency. One cannot avoid that,

but reactance also goes up with increases in capacitance and inductance. So

limiting capacitance or inductance in the electrodes will minimize the

resistance. Special electrodes with very small capacitance values were

utilized in this study to obtain the necessary field strength. Based upon

this finding, I would think it safe to say that the use of hand held

electrodes should be seriously examined by manufacturers of instruments

capable of 100,000 Hz frequency treatment ranges. It is very probable that

significant improvements in treatment outcomes can be obtained with the

use of different or modified electrodes.

>On average, the capacitance of each

>electrode is 8 nF. This translates into an impedance of 190 and

>95 ohms at 100 and 200 kHz, respectively. Because the impedance

>of the rat head is on the order of 400 ohms, when applying 42 V, 200

>kHz TTFields to rats, 14-V drop on the insulation of both

>electrodes and the remaining 28 V on the rat itself. The fields

>generated in the areas of interest are in the range of 1-2 V/cm.

Jim Bare

>

>BIOLOGICAL SCIENCES / MEDICAL SCIENCES

>Alternating electric fields arrest cell proliferation in animal tumor

>models and human brain tumors

>

>http://www.pnas.org/cgi/content/abstract/104/24/10152?etoc

>

>Dr.Bormann

>

>