Guest guest Posted March 16, 2007 Report Share Posted March 16, 2007 Hello all.... We are looking to purchase blower door testing equipment new or used please email information dschworn@.... Thanks Dan --- Tony Havics wrote: > . > > > > 1. You said there was human data and that > rats (animals) were not > sensitive enough to detect neuro effects and that I > should look at the IOM > book. > > > > Where is human data? > > > > and yes animals are affected (thus detectable, e.g., > the testing is > sensitive enough to detect, albeit at relatively > high levels). > > > > 2. But note the doses. > > > > 3. Then tell me what the exposure (doses) > are in built environments? > > > > As in how often are they (mycotoxins) produced, what > is their prevalence in > indoor environments, what amount is present on > surfaces and in air? > > > > 4. The only good data that I know of is on > women to DON, in an > agricultural/occupational exposure scenario over > years. > > > > Of course, if you want to learn more, I'll cover > some of the data in June at > AIHCE. > > > > Until, you have some homework to do. > > > > Tony > > ....................................................................... > > " Tony " Havics, CHMM, CIH, PE > > pH2, LLC > > 5250 E US 36, Suite 830 > > Avon, IN 46123 > > off > > fax > > cell > > > > 90% of Risk Management is knowing where to place the > decimal point...any > consultant can give you the other 10%(SM) > > > > This message is from pH2. This message and any > attachments may contain > legally privileged or confidential information, and > are intended only for > the individual or entity identified above as the > addressee. If you are not > the addressee, or if this message has been addressed > to you in error, you > are not authorized to read, copy, or distribute this > message and any > attachments, and we ask that you please delete this > message and attachments > (including all copies) and notify the sender by > return e-mail or by phone at > . Delivery of this message and any > attachments to any person > other than the intended recipient(s) is not intended > in any way to waive > confidentiality or a privilege. All personal > messages express views only of > the sender, which are not to be attributed to pH2 > and may not be copied or > distributed without this statement. > > _____ > > From: iequality > [mailto:iequality ] On Behalf > Of gary rosen > Sent: Wednesday, March 14, 2007 7:27 PM > To: iequality > Subject: Except on Mold Neurotoxins from > Damp Indoor Spaces by > Institute of Medicine > > > > The following regarding the neurotoxicity of Pen/Asp > are excerpted from > > the book Damp Indoor Spaces, published by The > National Academy of > > Sciences, Institute of Medicine 2004 p 160- 162. > > > > Neurotoxic mycotoxins tend to fall into three > general classes: > > tremorgenic toxins, paralytic toxins, and toxins > that interfere > > with neurotransmitters or receptors either centrally > or at the target > > organ. Many of the toxins are very potent and have > immediate > > effects on animals exposed to a single dose by > various routes. > > > > Tremor > > Tremorgenic toxins are produced predominantly by > Aspergillus > > and Penicillium species (Ciegler et al., 1976; Land > et al., 1994). > > The penitrem type of mycotoxins produces a > neurotoxic syndrome > > in animals that involves sustained tremors, limb > weakness, > > ataxia, and convulsions (Steyn and Vleggaar, 1985). > Tremorgenic > > toxins generally initiate measurable effects in > experimental > > animals within minutes of exposure. > > > > Paralysis > > Penicillium species also produce neurotoxins that > induce paralysis, > > such as Citreoviridin (produced by P. citreo-viride > and A. terreus) > > and verrucosidin (produced by P. verruculosum var. > cyclopium). > > (Franck and Gehrken, 1980; Hodge et al., 1988; Ueno > and > > Ueno, 1972). > > > > Those toxins produce a progressive, ascending > paralysis and are > > thought to act at the level of the interneurons and > motor neurons > > of the spinal cord and motor nerve cells of the > medulla (Ueno, > > 1984b). A typical pattern of poisoning begins with > paralysis of > > the hind legs, which is followed by a drop in body > temperature > === message truncated === Quote Link to comment Share on other sites More sharing options...
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