Re: a possibility...

[Guest guest]

Thanks , I'll definitely read up on it through your link. Don't discount yourself for your age. Many great achievers were young too. VinnySubject: a possibility...To: SSRIsex Date: Thursday, April 8, 2010, 10:03 PM

I hope I'm not overstepping my bounds by saying this, seeing as I'm only 18 years old, but…I have a theory. Now I know it's a stretch to rely on Wikipedia seeing that it's not the most accurate sight available but I read something in the article about SSRIs, http://en.wikipedia .org/wiki/ SSRI, that is ringing bells. Instead of looking for information on the sexual aspects of it I looked into the pharmocodynamics of SSRIs. The is a section there that reads as follows…

"SSRIs inhibit the reuptake of the neurotransmitter serotonin (5-hydroxytryptamin e or 5-HT) into the presynaptic cell, increasing levels of 5-HT within the synaptic cleft.

However, there is one counteracting effect: high serotonin levels will not only activate the postsynaptic receptors, but also flood presynaptic autoreceptors, that serve as a feedback sensor for the cell. Activation of the autoreceptors (by agonists like serotonin) triggers a throttling of serotonin production. The resulting serotonin deficiency persists for some time, as the transporter inhibition occurs downstream to the cause of the deficiency and therefore, is not able to counterbalance the serotonin deficiency. The body adapts gradually to this situation by lowering (downregulating) the sensitivity of the autoreceptors. [8]"

If you read the reference it goes into some more detail in regards to this but the basic of it is that at times SSRI's are shown to cause desensitization of the autoreceptor. The autoreceptor is key in regulating how much serotonin is produced AND when it is produced. Seeing that Serotonin is vital in both sexual arousal and penile erection one could assume that an imbalance in its regulator, the autoreceptor, would cause problems perhaps similar to our own.

If you look into this there are countless studies that discuss this but few that talk about resensitization (not a real word) of autoreceptors. This would explain why so many people who have tried to cure themselves of this haven't had good results. There are very few drugs that can make an autoreceptor MORE sensitive. One I do not have enough access to in order to make a good conclusion but it does discuss the possibility of drugs that could induce a reversing effect, http://www.scienced irect.com/ science?_ ob=ArticleURL & _udi=B6T1J-

47BX8KW180 & _user=10 & _coverDate= 01/27/1984 & _rdoc=1 & _ fmt=high & _orig=search & _sort=d & _ docanchor= & view=c & _ searchStrId= 1178750721 & _rerunOrigin= scholar.google & _acct=C000050221 & _version= 1 & _urlVersion= 0 & _userid= 10 & md5=c496ec195 89e0e9a5d2673077 b8fec39. The distinct difference between SSRI induced Sexual Dysfunction and PSSD may be made clearer in this article detailing differences in the effects of the WAY-100635 series of drugs regarding the autoreceptor system. This would unfortunately prove that these drugs could not help us which has also been indicated… http://www.nature. com/npp/journal/ v24/n1/full/ 1395583a. html

The only thing left for us to do then is find a drug that could resensitize a desensitized autoreceptor. I haven't seen much that even indicated this as a possibility but it has been done. I know that some studies, though I can't find them right now, indicate that a drug known as 8-oh-dpat may have the properties necessary to do just that. Take a note that I am only an 18 year old boy. I have no experience in this field whatsoever. So its not like I couldn't be totally wrong. However for the most part this is what I have come up with…do with it what you will. I want the same things everybody here wants…a cure and I only hope I've made a significant contribution to that end.

[Guest guest]

I think thats why should try to get some publicity to our problem - not to win

lawsuits, but to make labs verify hypothesis like that. Without that it would be

hard to find cure for most of us.

Your hypothesis seems plausible, and can in some way explain sypmtoms in my case

- i had sexual side effects (mostly low libido, anaesthesia) during SSRI, which

changed after withdrawal into terrible erectile dysfunction (with libido and

pleasure coming back to at least acceptable levels)

>

>

> Subject: a possibility...

> To: SSRIsex

> Date: Thursday, April 8, 2010, 10:03 PM

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> I hope I'm not overstepping my bounds by saying this, seeing as I'm only

18 years old, butâ & #65533;I have a theory. Now I know it's a stretch to rely on

Wikipedia seeing that it's not the most accurate sight available but I read

something in the article about SSRIs, http://en.wikipedia .org/wiki/ SSRI, that

is ringing bells. Instead of looking for information on the sexual aspects of it

I looked into the pharmocodynamics of SSRIs. The is a section there that reads

as followsâ & #65533;

>

> " SSRIs inhibit the reuptake of the neurotransmitter serotonin

(5-hydroxytryptamin e or 5-HT) into the presynaptic cell, increasing levels of

5-HT within the synaptic cleft.

>

> However, there is one counteracting effect: high serotonin levels will not

only activate the postsynaptic receptors, but also flood presynaptic

autoreceptors, that serve as a feedback sensor for the cell. Activation of the

autoreceptors (by agonists like serotonin) triggers a throttling of serotonin

production. The resulting serotonin deficiency persists for some time, as the

transporter inhibition occurs downstream to the cause of the deficiency and

therefore, is not able to counterbalance the serotonin deficiency. The body

adapts gradually to this situation by lowering (downregulating) the sensitivity

of the autoreceptors. [8] "

>

> If you read the reference it goes into some more detail in regards to this but

the basic of it is that at times SSRI's are shown to cause desensitization of

the autoreceptor. The autoreceptor is key in regulating how much serotonin is

produced AND when it is produced. Seeing that Serotonin is vital in both sexual

arousal and penile erection one could assume that an imbalance in its regulator,

the autoreceptor, would cause problems perhaps similar to our own.

>

> If you look into this there are countless studies that discuss this but few

that talk about resensitization (not a real word) of autoreceptors. This would

explain why so many people who have tried to cure themselves of this haven't had

good results. There are very few drugs that can make an autoreceptor MORE

sensitive. One I do not have enough access to in order to make a good conclusion

but it does discuss the possibility of drugs that could induce a reversing

effect, http://www.scienced irect.com/ science?_ ob=ArticleURL & _udi=B6T1J-

47BX8KW180 & _user=10 & _coverDate= 01/27/1984 & _rdoc=1 & _ fmt=high & _orig=search &

_sort=d & _ docanchor= & view=c & _ searchStrId= 1178750721 & _rerunOrigin=

scholar.google & _acct=C000050221 & _version= 1 & _urlVersion= 0 & _userid=

10 & md5=c496ec195 89e0e9a5d2673077 b8fec39. The distinct difference between SSRI

induced Sexual Dysfunction and PSSD may be made clearer in this article

detailing differences in the effects of the WAY-100635

> series of drugs regarding the autoreceptor system. This would unfortunately

prove that these drugs could not help us which has also been indicatedâ & #65533;

http://www.nature. com/npp/journal/ v24/n1/full/ 1395583a. html

>

> The only thing left for us to do then is find a drug that could resensitize a

desensitized autoreceptor. I haven't seen much that even indicated this as a

possibility but it has been done. I know that some studies, though I can't find

them right now, indicate that a drug known as 8-oh-dpat may have the properties

necessary to do just that. Take a note that I am only an 18 year old boy. I have

no experience in this field whatsoever. So its not like I couldn't be totally

wrong. However for the most part this is what I have come up withâ & #65533;do

with it what you will. I want the same things everybody here wantsâ & #65533;a

cure and I only hope I've made a significant contribution to that end.

>

[Guest guest]

,

You may be half my age, but your theory sounds extremely interesting (I don't

understand half of it, but I get the general gist regarding resensitizing

autoreceptors). I've often wondered why, if it's just that our dopamine levels

have decreased, as some have suggested, then why the hell adding dopamine

doesn't completely cure us?

Anyways, could you look into this a bit more? I'm curious if there are any

drugs that might do what you're suggesting? I know a lot of people on this site

are very opposed to trying new drugs (and I don't fault them for that), but I

for one would give something like this a try.

You should also try to pass your idea onto a doctor who specializes in this kind

of thing - someone like Dr G (who many people have mentioned). See if he knows

of any drugs like this or has any thoughts to add.

Very interesting...

Thanks!

-M

>

> I hope I'm not overstepping my bounds by saying this, seeing as I'm only 18

years old, but…I have a theory. Now I know it's a stretch to rely on Wikipedia

seeing that it's not the most accurate sight available but I read something in

the article about SSRIs, http://en.wikipedia.org/wiki/SSRI, that is ringing

bells. Instead of looking for information on the sexual aspects of it I looked

into the pharmocodynamics of SSRIs. The is a section there that reads as

follows…

> " SSRIs inhibit the reuptake of the neurotransmitter serotonin

(5-hydroxytryptamine or 5-HT) into the presynaptic cell, increasing levels of

5-HT within the synaptic cleft.

> However, there is one counteracting effect: high serotonin levels will not

only activate the postsynaptic receptors, but also flood presynaptic

autoreceptors, that serve as a feedback sensor for the cell. Activation of the

autoreceptors (by agonists like serotonin) triggers a throttling of serotonin

production. The resulting serotonin deficiency persists for some time, as the

transporter inhibition occurs downstream to the cause of the deficiency and

therefore, is not able to counterbalance the serotonin deficiency. The body

adapts gradually to this situation by lowering (downregulating) the sensitivity

of the autoreceptors.[8] "

> If you read the reference it goes into some more detail in regards to this but

the basic of it is that at times SSRI's are shown to cause desensitization of

the autoreceptor. The autoreceptor is key in regulating how much serotonin is

produced AND when it is produced. Seeing that Serotonin is vital in both sexual

arousal and penile erection one could assume that an imbalance in its regulator,

the autoreceptor, would cause problems perhaps similar to our own.

> If you look into this there are countless studies that discuss this but few

that talk about resensitization (not a real word) of autoreceptors. This would

explain why so many people who have tried to cure themselves of this haven't had

good results. There are very few drugs that can make an autoreceptor MORE

sensitive. One I do not have enough access to in order to make a good conclusion

but it does discuss the possibility of drugs that could induce a reversing

effect,

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6T1J-47BX8KW180 & _user=\

10 & _coverDate=01/27/1984 & _rdoc=1 & _fmt=high & _orig=search & _sort=d & _docanchor= & view\

=c & _searchStrId=1178750721 & _rerunOrigin=scholar.google & _acct=C000050221 & _version\

=1 & _urlVersion=0 & _userid=10 & md5=c496ec19589e0e9a5d2673077b8fec39. The distinct

difference between SSRI induced Sexual Dysfunction and PSSD may be made clearer

in this article detailing differences in the effects of the WAY-100635 series of

drugs regarding the autoreceptor system. This would unfortunately prove that

these drugs could not help us which has also been indicated…

http://www.nature.com/npp/journal/v24/n1/full/1395583a.html

> The only thing left for us to do then is find a drug that could resensitize a

desensitized autoreceptor. I haven't seen much that even indicated this as a

possibility but it has been done. I know that some studies, though I can't find

them right now, indicate that a drug known as 8-oh-dpat may have the properties

necessary to do just that. Take a note that I am only an 18 year old boy. I have

no experience in this field whatsoever. So its not like I couldn't be totally

wrong. However for the most part this is what I have come up with…do with it

what you will. I want the same things everybody here wants…a cure and I only

hope I've made a significant contribution to that end.

>

[Guest guest]

I actually have looked into this a lot, see I got off prozac about two years ago

but my libido never came back to what it was. In fact a lot of times I could

swear I don't even have a sexual orientation. At the dawn of last summer I found

out about PSSD so I decided I might look into it. I've been doing research since

then and I finally stumbled upon this. Thing is the internet has hit its limit

to what it can give me regarding these kinds of things. I need real expert

material to get a better idea of what can help us. Since resensitizing the

autoreceptor seems to be a rare ability in any drug I've had problems isolating

one that has been tested and shown to do that consistently. Now about Dr. G,

I've heard some good things about him but I don't know how to get in contact.

Maybe he can give me a better opinion...

> >

> > I hope I'm not overstepping my bounds by saying this, seeing as I'm only 18

years old, but…I have a theory. Now I know it's a stretch to rely on Wikipedia

seeing that it's not the most accurate sight available but I read something in

the article about SSRIs, http://en.wikipedia.org/wiki/SSRI, that is ringing

bells. Instead of looking for information on the sexual aspects of it I looked

into the pharmocodynamics of SSRIs. The is a section there that reads as

follows…

> > " SSRIs inhibit the reuptake of the neurotransmitter serotonin

(5-hydroxytryptamine or 5-HT) into the presynaptic cell, increasing levels of

5-HT within the synaptic cleft.

> > However, there is one counteracting effect: high serotonin levels will not

only activate the postsynaptic receptors, but also flood presynaptic

autoreceptors, that serve as a feedback sensor for the cell. Activation of the

autoreceptors (by agonists like serotonin) triggers a throttling of serotonin

production. The resulting serotonin deficiency persists for some time, as the

transporter inhibition occurs downstream to the cause of the deficiency and

therefore, is not able to counterbalance the serotonin deficiency. The body

adapts gradually to this situation by lowering (downregulating) the sensitivity

of the autoreceptors.[8] "

> > If you read the reference it goes into some more detail in regards to this

but the basic of it is that at times SSRI's are shown to cause desensitization

of the autoreceptor. The autoreceptor is key in regulating how much serotonin is

produced AND when it is produced. Seeing that Serotonin is vital in both sexual

arousal and penile erection one could assume that an imbalance in its regulator,

the autoreceptor, would cause problems perhaps similar to our own.

> > If you look into this there are countless studies that discuss this but few

that talk about resensitization (not a real word) of autoreceptors. This would

explain why so many people who have tried to cure themselves of this haven't had

good results. There are very few drugs that can make an autoreceptor MORE

sensitive. One I do not have enough access to in order to make a good conclusion

but it does discuss the possibility of drugs that could induce a reversing

effect,

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6T1J-47BX8KW180 & _user=\

10 & _coverDate=01/27/1984 & _rdoc=1 & _fmt=high & _orig=search & _sort=d & _docanchor= & view\

=c & _searchStrId=1178750721 & _rerunOrigin=scholar.google & _acct=C000050221 & _version\

=1 & _urlVersion=0 & _userid=10 & md5=c496ec19589e0e9a5d2673077b8fec39. The distinct

difference between SSRI induced Sexual Dysfunction and PSSD may be made clearer

in this article detailing differences in the effects of the WAY-100635 series of

drugs regarding the autoreceptor system. This would unfortunately prove that

these drugs could not help us which has also been indicated…

http://www.nature.com/npp/journal/v24/n1/full/1395583a.html

> > The only thing left for us to do then is find a drug that could resensitize

a desensitized autoreceptor. I haven't seen much that even indicated this as a

possibility but it has been done. I know that some studies, though I can't find

them right now, indicate that a drug known as 8-oh-dpat may have the properties

necessary to do just that. Take a note that I am only an 18 year old boy. I have

no experience in this field whatsoever. So its not like I couldn't be totally

wrong. However for the most part this is what I have come up with…do with it

what you will. I want the same things everybody here wants…a cure and I only

hope I've made a significant contribution to that end.

> >

>

[Guest guest]

,This is Dr Goldstein's practice: http://www.sandiegosexualmedicine.com/He will do a 15 minute call to discuss your case free of charge.Dunno where you're based but Dr Goldstein recommended Dean as a UK expert.http://www.sexualmedicine.org/Dean.aspHenryFrom:

To: SSRIsex Sent: Sun, 11 April, 2010 5:10:11Subject: Re: a possibility...

I actually have looked into this a lot, see I got off prozac about two years ago but my libido never came back to what it was. In fact a lot of times I could swear I don't even have a sexual orientation. At the dawn of last summer I found out about PSSD so I decided I might look into it. I've been doing research since then and I finally stumbled upon this. Thing is the internet has hit its limit to what it can give me regarding these kinds of things. I need real expert material to get a better idea of what can help us. Since resensitizing the autoreceptor seems to be a rare ability in any drug I've had problems isolating one that has been tested and shown to do that consistently. Now about Dr. G, I've heard some good things about him but I don't know how to get in contact. Maybe he can give me a better opinion...

> >

> > I hope I'm not overstepping my bounds by saying this, seeing as I'm only 18 years old, but…I have a theory. Now I know it's a stretch to rely on Wikipedia seeing that it's not the most accurate sight available but I read something in the article about SSRIs, http://en.wikipedia .org/wiki/ SSRI, that is ringing bells. Instead of looking for information on the sexual aspects of it I looked into the pharmocodynamics of SSRIs. The is a section there that reads as follows…

> > "SSRIs inhibit the reuptake of the neurotransmitter serotonin (5-hydroxytryptamin e or 5-HT) into the presynaptic cell, increasing levels of 5-HT within the synaptic cleft.

> > However, there is one counteracting effect: high serotonin levels will not only activate the postsynaptic receptors, but also flood presynaptic autoreceptors, that serve as a feedback sensor for the cell. Activation of the autoreceptors (by agonists like serotonin) triggers a throttling of serotonin production. The resulting serotonin deficiency persists for some time, as the transporter inhibition occurs downstream to the cause of the deficiency and therefore, is not able to counterbalance the serotonin deficiency. The body adapts gradually to this situation by lowering (downregulating) the sensitivity of the autoreceptors. [8]"

> > If you read the reference it goes into some more detail in regards to this but the basic of it is that at times SSRI's are shown to cause desensitization of the autoreceptor. The autoreceptor is key in regulating how much serotonin is produced AND when it is produced. Seeing that Serotonin is vital in both sexual arousal and penile erection one could assume that an imbalance in its regulator, the autoreceptor, would cause problems perhaps similar to our own.

> > If you look into this there are countless studies that discuss this but few that talk about resensitization (not a real word) of autoreceptors. This would explain why so many people who have tried to cure themselves of this haven't had good results. There are very few drugs that can make an autoreceptor MORE sensitive. One I do not have enough access to in order to make a good conclusion but it does discuss the possibility of drugs that could induce a reversing effect, http://www.scienced irect.com/ science?_ ob=ArticleURL & _udi=B6T1J-

47BX8KW180 & _user=10 & _coverDate= 01/27/1984 & _rdoc=1 & _ fmt=high & _orig=search & _sort=d & _ docanchor= & view=c & _ searchStrId= 1178750721 & _rerunOrigin= scholar.google & _acct=C000050221 & _version= 1 & _urlVersion= 0 & _userid= 10 & md5=c496ec195 89e0e9a5d2673077 b8fec39. The distinct difference between SSRI induced Sexual Dysfunction and PSSD may be made clearer in this article detailing differences in the effects of the WAY-100635 series of drugs regarding the autoreceptor system. This would unfortunately prove that these drugs could not help us which has also been indicated… http://www.nature. com/npp/journal/ v24/n1/full/ 1395583a. html

> > The only thing left for us to do then is find a drug that could resensitize a desensitized autoreceptor. I haven't seen much that even indicated this as a possibility but it has been done. I know that some studies, though I can't find them right now, indicate that a drug known as 8-oh-dpat may have the properties necessary to do just that. Take a note that I am only an 18 year old boy. I have no experience in this field whatsoever. So its not like I couldn't be totally wrong. However for the most part this is what I have come up with…do with it what you will. I want the same things everybody here wants…a cure and I only hope I've made a significant contribution to that end.

> >

>

[Guest guest]

I actually have looked into this a lot, see I got off prozac about two years ago

but my libido never came back to what it was. In fact a lot of times I could

swear I don't even have a sexual orientation. At the dawn of last summer I found

out about PSSD so I decided I might look into it. I've been doing research since

then and I finally stumbled upon this. Thing is the internet has hit its limit

to what it can give me regarding these kinds of things. I need real expert

material to get a better idea of what can help us. Since resensitizing the

autoreceptor seems to be a rare ability in any drug I've had problems isolating

one that has been tested and shown to do that consistently. Now about Dr. G,

I've heard some good things about him but I don't know how to get in contact.

Maybe he can give me a better opinion...

> > >

> > > I hope I'm not overstepping my bounds by saying this, seeing as I'm only

18 years old, but…I have a theory. Now I know it's a stretch to rely on

Wikipedia seeing that it's not the most accurate sight available but I read

something in the article about SSRIs, http://en.wikipedia.org/wiki/SSRI, that is

ringing bells. Instead of looking for information on the sexual aspects of it I

looked into the pharmocodynamics of SSRIs. The is a section there that reads as

follows…

> > > " SSRIs inhibit the reuptake of the neurotransmitter serotonin

(5-hydroxytryptamine or 5-HT) into the presynaptic cell, increasing levels of

5-HT within the synaptic cleft.

> > > However, there is one counteracting effect: high serotonin levels will not

only activate the postsynaptic receptors, but also flood presynaptic

autoreceptors, that serve as a feedback sensor for the cell. Activation of the

autoreceptors (by agonists like serotonin) triggers a throttling of serotonin

production. The resulting serotonin deficiency persists for some time, as the

transporter inhibition occurs downstream to the cause of the deficiency and

therefore, is not able to counterbalance the serotonin deficiency. The body

adapts gradually to this situation by lowering (downregulating) the sensitivity

of the autoreceptors.[8] "

> > > If you read the reference it goes into some more detail in regards to this

but the basic of it is that at times SSRI's are shown to cause desensitization

of the autoreceptor. The autoreceptor is key in regulating how much serotonin is

produced AND when it is produced. Seeing that Serotonin is vital in both sexual

arousal and penile erection one could assume that an imbalance in its regulator,

the autoreceptor, would cause problems perhaps similar to our own.

> > > If you look into this there are countless studies that discuss this but

few that talk about resensitization (not a real word) of autoreceptors. This

would explain why so many people who have tried to cure themselves of this

haven't had good results. There are very few drugs that can make an autoreceptor

MORE sensitive. One I do not have enough access to in order to make a good

conclusion but it does discuss the possibility of drugs that could induce a

reversing effect,

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6T1J-47BX8KW180 & _user=\

10 & _coverDate=01/27/1984 & _rdoc=1 & _fmt=high & _orig=search & _sort=d & _docanchor= & view\

=c & _searchStrId=1178750721 & _rerunOrigin=scholar.google & _acct=C000050221 & _version\

=1 & _urlVersion=0 & _userid=10 & md5=c496ec19589e0e9a5d2673077b8fec39. The distinct

difference between SSRI induced Sexual Dysfunction and PSSD may be made clearer

in this article detailing differences in the effects of the WAY-100635 series of

drugs regarding the autoreceptor system. This would unfortunately prove that

these drugs could not help us which has also been indicated…

http://www.nature.com/npp/journal/v24/n1/full/1395583a.html

> > > The only thing left for us to do then is find a drug that could

resensitize a desensitized autoreceptor. I haven't seen much that even indicated

this as a possibility but it has been done. I know that some studies, though I

can't find them right now, indicate that a drug known as 8-oh-dpat may have the

properties necessary to do just that. Take a note that I am only an 18 year old

boy. I have no experience in this field whatsoever. So its not like I couldn't

be totally wrong. However for the most part this is what I have come up with…do

with it what you will. I want the same things everybody here wants…a cure and I

only hope I've made a significant contribution to that end.

> > >

> >

>Hi, some time ago I came up with this theory regarding our condition. When I

described it to you I gave you all the name of a non-commercial drug that could

re-sensitize a desensitized autoreceptor. This drug, 8-OH-DPAT, is the only one

that I can find with such a property. Now since it has been established in many

research articles that ssri's desensitize autoreceptors I'd hoped to connects

our condition with that effect.

http://grande.nal.usda.gov/ibids/index.php?mode2=detail & origin=ibids_references & \

therow=364582 This article provides a description of 8-OH-DPAT's sexual effects.

I believe this article is interesting as it measured the effects of the drug on

106 castrated mice with variable levels of testosterone. The ones with high

testosterone but no sex drive due to castration reacted very stimulated while

the ones with low levels of testosterone had little to no reaction. I believe

this could have some connection to our condition as it had been stated time and

again that many of us seem to have normal levels of testosterone...

[Guest guest]

Hi ,

If you want to get in touch with Dr.G, google for San Diego Sexual medicine and you can visit their website and set up a free initial phone consultation. Good luck.

Thanks

Steve

Subject: Re: a possibility...To: SSRIsex Date: Sunday, May 9, 2010, 8:30 PM

I actually have looked into this a lot, see I got off prozac about two years ago but my libido never came back to what it was. In fact a lot of times I could swear I don't even have a sexual orientation. At the dawn of last summer I found out about PSSD so I decided I might look into it. I've been doing research since then and I finally stumbled upon this. Thing is the internet has hit its limit to what it can give me regarding these kinds of things. I need real expert material to get a better idea of what can help us. Since resensitizing the autoreceptor seems to be a rare ability in any drug I've had problems isolating one that has been tested and shown to do that consistently. Now about Dr. G, I've heard some good things about him but I don't know how to get in contact. Maybe he can give me a better opinion...> > >> > > I hope I'm not overstepping my bounds by saying this, seeing as I'm only 18 years old, but…I have a theory. Now I know it's a stretch to rely on Wikipedia seeing that it's not the most accurate sight

available but I read something in the article about SSRIs, http://en.wikipedia .org/wiki/ SSRI, that is ringing bells. Instead of looking for information on the sexual aspects of it I looked into the pharmocodynamics of SSRIs. The is a section there that reads as follows…> > > "SSRIs inhibit the reuptake of the neurotransmitter serotonin (5-hydroxytryptamin e or 5-HT) into the presynaptic cell, increasing levels of 5-HT within the synaptic cleft.> > > However, there is one counteracting effect: high serotonin levels will not only activate the postsynaptic receptors, but also flood presynaptic autoreceptors, that serve as a feedback sensor for the cell. Activation of the autoreceptors (by agonists like serotonin) triggers a throttling of serotonin production. The resulting serotonin deficiency persists for some time, as the transporter inhibition

occurs downstream to the cause of the deficiency and therefore, is not able to counterbalance the serotonin deficiency. The body adapts gradually to this situation by lowering (downregulating) the sensitivity of the autoreceptors. [8]"> > > If you read the reference it goes into some more detail in regards to this but the basic of it is that at times SSRI's are shown to cause desensitization of the autoreceptor. The autoreceptor is key in regulating how much serotonin is produced AND when it is produced. Seeing that Serotonin is vital in both sexual arousal and penile erection one could assume that an imbalance in its regulator, the autoreceptor, would cause problems perhaps similar to our own. > > > If you look into this there are countless studies that discuss this but few that talk about resensitization (not a real word) of autoreceptors. This would explain why so many people who have tried to cure themselves of this haven't

had good results. There are very few drugs that can make an autoreceptor MORE sensitive. One I do not have enough access to in order to make a good conclusion but it does discuss the possibility of drugs that could induce a reversing effect, http://www.scienced irect.com/ science?_ ob=ArticleURL & _udi=B6T1J- 47BX8KW180 & _user=10 & _coverDate= 01/27/1984 & _rdoc=1 & _ fmt=high & _orig=search & _sort=d & _ docanchor= & view=c & _ searchStrId= 1178750721 & _rerunOrigin= scholar.google & _acct=C000050221 & _version=

1 & _urlVersion= 0 & _userid= 10 & md5=c496ec195 89e0e9a5d2673077 b8fec39. The distinct difference between SSRI induced Sexual Dysfunction and PSSD may be made clearer in this article detailing differences in the effects of the WAY-100635 series of drugs regarding the autoreceptor system. This would unfortunately prove that these drugs could not help us which has also been indicated… http://www.nature. com/npp/journal/ v24/n1/full/ 1395583a. html> > > The only thing left for us to do then is find a drug that could resensitize a desensitized autoreceptor. I haven't seen much that even indicated this as a possibility but it has been done. I know that some studies, though I can't find them right now, indicate that a drug known as 8-oh-dpat may have the properties necessary to do just that. Take a note that I am only an 18 year old

boy. I have no experience in this field whatsoever. So its not like I couldn't be totally wrong. However for the most part this is what I have come up with…do with it what you will. I want the same things everybody here wants…a cure and I only hope I've made a significant contribution to that end.> > >> >>Hi, some time ago I came up with this theory regarding our condition. When I described it to you I gave you all the name of a non-commercial drug that could re-sensitize a desensitized autoreceptor. This drug, 8-OH-DPAT, is the only one that I can find with such a property. Now since it has been established in many research articles that ssri's desensitize autoreceptors I'd hoped to connects our condition with that effect. http://grande. nal.usda. gov/ibids/ index.php?

mode2=detail & origin=ibids_ references & therow=364582 This article provides a description of 8-OH-DPAT's sexual effects. I believe this article is interesting as it measured the effects of the drug on 106 castrated mice with variable levels of testosterone. The ones with high testosterone but no sex drive due to castration reacted very stimulated while the ones with low levels of testosterone had little to no reaction. I believe this could have some connection to our condition as it had been stated time and again that many of us seem to have normal levels of testosterone. ..