B6 (was diet for obesity and leptin or something like that)

[Guest guest]

> Well, the body does have a limited ability to convert pyridoxine

to P5P (or

> PLP, as it's more properly called) so that would probably explain

it. I

> don't think pyridoxine is used for anything itself, though, and

the body

> doesn't convert anything back to PN either, whereas PM and PL

exist in

> equilibrium and can be converted in either direction as necessary.

>

> -

,

Okay, so where are you getting all your juicey B6 information?

I found this statement on the internet " Pyridoxal phosphate is not

taken orally unless enterically coated because it is destroyed by

the digestion process " . If that's true that may explain why the

doctor found that PLP doesn't work for some people - maybe they were

taking non-coated PLP or non-sublingual?

And, " Two enzymatic steps are required for the conversion of

inactive Vit B6 (pyridoxine) to active pyridoxal-5-phosphate (P5P or

PLP). The first is phosphorylation of pyridoxine by pyridoxine

kinase, which itself requires magnesium and P5P. The second is

oxidation of pyridoxine phosphate, which requires riboflavin (Vit

B2) " which probably isn't exactly right, but that would explain why

some people are getting good results with pyridoxine in combo with

just a little PLP and the recommended Mg supplement this doctor also

requires.

Anyway, my question... do you see anything really, really bad about

taking pyridoxine. I've got a couple of bottles of the Thorne B6

formulation that has both forms and the cheapskate in me wants to

finish the bottles since they are working really well for me before

I look into finding a better source?

Just being nosey, are you some type of scientist/engineer or do you

have a chemistry/science related degree?

Katy