What is Inositol?

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Inositol is part of the vitamin B-complex. It is required for proper

formation of cell membranes.

Inositol affects nerve transmission and helps in transporting fats

within the body. Inositol differs from inositol hexaniacinate, a

form of vitamin B3.

Where is it found?

Nuts, beans, wheat and wheat bran, cantaloupe, and oranges are

excellent sources of inositol. Most dietary inositol is in the form

of phytate.

Who is likely to be deficient?

Clear deficiency of inositol has not been reported, although people

with diabetes have increased excretion and may benefit from inositol

supplementation.

How much is usually taken?

Most people do not need to take inositol. In addition, the small

amounts commonly found in multivitamin supplements are probably

unnecessary and ineffective. Doctors sometimes suggest 500 mg twice

per day. For depression, anxiety, and obsessive-compulsive disorder,

12–18 grams per day has been shown to be effective in double-blind

trials.1 2 3 4

Are there any side effects or interactions?

Toxicity has not been reported, although people with chronic renal

failure show elevated levels and should not take inositol, except

under medical supervision.

Large amounts of phytate, the common dietary form of inositol,

reduce the absorption of calcium, iron, and zinc. However,

supplemental inositol does not have this effect.

One review article suggested that inositol may stimulate uterine

contractions.5 While no research has demonstrated that inositol

actually has this effect, women who are or could become pregnant

should consult a doctor before taking inositol.

Are there any drug interactions?

Certain medicines may interact with inositol. Refer to drug

interactions for a list of those medicines.