Re: cabergoline

[Guest guest]

It is very strange that the article calls it psychogenic.

Anyway, yes, I have tried it. The first dose made me hyper-sexual.

The second dose had a very weak effect. After that, it doesn't work anymore.

>

> Hello my friends

>

> http://www.nature.com/ijir/journal/v19/n1/abs/3901483a.html

>

> Does anybody have tried cabergoline?

>

[Guest guest]

Nature's Way Vitex Fruit, 1 capsule (400mg), two or three times a day, can reduce prolactin. Vitex is dopaminergic. It can be bought for around $5.00 per bottle online. I've been taking one 400mg capsule, three times per day of Nature's way Vitex Fruit for a week to reduce prolactin (and so increase dopamine) and there's been some mild improvement (nothing dramatic), but it's early days yet. I'm also remembering my dreams in the morning. I've read that lowering prolactin too low to the opposite extreme might have a negative impact on libido.

http://www.ncbi.nlm.nih.gov/pubmed/9021345

http://www.ncbi.nlm.nih.gov/pubmed/12809367

http://www.ncbi.nlm.nih.gov/pubmed/19070148

>> > I was reading another message board where the hypothesis that the serotonin effect is anorgasmia with no effect on libido/hardness. Whereas the low libido is more likely to be a result of the prolactin elevation that accompanies many antidepressants.> > The only concrete evidence I have of PSSD was the significant rise in prolactin levels shortly after taking the SSRi which induced it. While my levels returned to what medical guidelines would phrase as normal I am interested to see if an agent that reduces prolactin such as cabergoline would have a benefit. > > The only thing is that it is so expensive i would not be able to take it indefinitely. So I am kinda hoping that if I push my prolactin way down in the other direction my body will push me towards homeostasis and find a happy medium which corrects any disruption of the prolactin that lingers after ssri use.> > Anyone tried this?>

[Guest guest]

A low dose of Vitex increases prolactin which is why it would reduce libido but a higher dose of Vitex reduces prolactin (and so increasing dopamine and libido) as explained in the PubMed study:

The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects.

Merz PG, Gorkow C, Schrödter A, Rietbrock S, Sieder C, Loew D, Dericks-Tan JS, Taubert HD.

Department for Clinical Pharmacology, furt University Clinic, Neumarkt, Germany.

Abstract

The effects of three doses of a special Agnus castus extract (BP1095E1)--extracts from 120 mg, 240 mg and 480 mg of drug per day--were examined within the framework of a placebo-controlled clinical study of tolerance and prolactin secretion in 20 healthy male subjects during a period of 14 days. There was good tolerance during the study as regards the following: adverse effects, the effects on blood pressure and heart rate, blood count, Quick's test, clinical chemistry as well as testosterone, FSH and LH values. During each study phase the 24-hour prolactin secretion profile was measured from the penultimate to the final day, and the amount of prolactin release was monitored an hour after TRH stimulation on the last day. A significant increase in the 24-hour profile was registered with the lowest dose in comparison to placebo, the opposite being the case with the higher doses, i.e. a slight reduction. In contrast to the administration of placebo, the 1-hour AUC after TRH stimulation resulted in a significant increase with the lowest dose and a significant reduction with the highest dose. The results suggest effects of the special Agnus castus extract which are dependent on the dose administered and the initial level of prolactin concentration.

PMID: 9021345 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/9021345

> > >> > >> > > I was reading another message board where the hypothesis that the> > serotonin effect is anorgasmia with no effect on libido/hardness. Whereas> > the low libido is more likely to be a result of the prolactin elevation that> > accompanies many antidepressants.> > >> > > The only concrete evidence I have of PSSD was the significant rise in> > prolactin levels shortly after taking the SSRi which induced it. While my> > levels returned to what medical guidelines would phrase as normal I am> > interested to see if an agent that reduces prolactin such as cabergoline> > would have a benefit.> > >> > > The only thing is that it is so expensive i would not be able to take it> > indefinitely. So I am kinda hoping that if I push my prolactin way down in> > the other direction my body will push me towards homeostasis and find a> > happy medium which corrects any disruption of the prolactin that lingers> > after ssri use.> > >> > > Anyone tried this?> > >> > > >>

[Guest guest]

For some folks, these gains continued even after discontinued these drugs. For others, not so.

Nature's Way Vitex Fruit, 1 capsule (400mg), two or three times a day, can reduce prolactin. Vitex is dopaminergic. It can be bought for around $5.00 per bottle online. I've been taking one 400mg capsule, three times per day of Nature's way Vitex Fruit for a week to reduce prolactin (and so increase dopamine) and there's been some mild improvement ( nothing dramatic), but it's early days yet. I'm also remembering my dreams in the morning. I've read that lowering prolactin too low to the opposite extreme might have a negative impact on libido.

http://www.ncbi. nlm.nih.gov/ pubmed/9021345

http://www.ncbi. nlm.nih.gov/ pubmed/12809367

http://www.ncbi. nlm.nih.gov/ pubmed/19070148

>> > I was reading another message board where the hypothesis that the serotonin effect is anorgasmia with no effect on libido/hardness. Whereas the low libido is more likely to be a result of the prolactin elevation that accompanies many antidepressants.> > The only concrete evidence I have of PSSD was the significant rise in prolactin levels shortly after taking the SSRi which induced it. While my levels returned to what medical guidelines would phrase as normal I am interested to see if an agent that reduces prolactin such as cabergoline would have a benefit. > > The only thing is that it is so expensive i would not be able to take it indefinitely. So I am kinda hoping

that if I push my prolactin way down in the other direction my body will push me towards homeostasis and find a happy medium which corrects any disruption of the prolactin that lingers after ssri use.> > Anyone tried this?>

[Guest guest]

I've tried it. It worked for a couple days. But my problem was caused by

risperdal not an SSRI. Your situation and results might be different. Where are

you from?

>

>

> I was reading another message board where the hypothesis that the serotonin

effect is anorgasmia with no effect on libido/hardness. Whereas the low libido

is more likely to be a result of the prolactin elevation that accompanies many

antidepressants.

>

> The only concrete evidence I have of PSSD was the significant rise in

prolactin levels shortly after taking the SSRi which induced it. While my levels

returned to what medical guidelines would phrase as normal I am interested to

see if an agent that reduces prolactin such as cabergoline would have a benefit.

>

> The only thing is that it is so expensive i would not be able to take it

indefinitely. So I am kinda hoping that if I push my prolactin way down in the

other direction my body will push me towards homeostasis and find a happy medium

which corrects any disruption of the prolactin that lingers after ssri use.

>

> Anyone tried this?

>

[Guest guest]

My prolactin seems to be low enough (5 vs the normal range of 2-18), so does it make sense for a few doses of dostinex? If I'm leaning towards using a dopamine agonist, is it possible that Dostinex might still work even though prolactin is already low?

[Guest guest]

It might be worth a try just to restore dopaminergic activity, but dostinex is

more geared toward lowering prolactin and affecting motor function because it is

a highly selective D2 agonist. It might have some beneficial mental effects, but

as far as what I've read, D3-preferring agonists have a more robust effect on

reward behavior and often cause effects like hypersexuality. That leaves you

with pramipexole (Mirapex) and ropinirole (Requip). You will see both of these

advertised on TV for restless legs syndrome. If you can get a psychiatrist to

prescribe one or the other it might be worth a shot. The only downside that has

prevented me from trying one is that they cause drowsiness and I'm already very

fatigued. BTW cabergoline (Dostinex) has been associated with fibrotic tumors.

All the ergot-derived agonists carry this effect, but cabergoline much more so.

Pramipexole and ropinirole are fully synthetic and non-ergot derivitives and

have no reports of this effect.

>

> My prolactin seems to be low enough (5 vs the normal range of 2-18), so does

it make sense for a few doses of dostinex? If I'm leaning towards using a

dopamine agonist, is it possible that Dostinex might still work even though

prolactin is already low?

>

[Guest guest]

what about bromocrypyline as a cheaper prolactin reducer?

 

It might be worth a try just to restore dopaminergic activity, but dostinex is more geared toward lowering prolactin and affecting motor function because it is a highly selective D2 agonist. It might have some beneficial mental effects, but as far as what I've read, D3-preferring agonists have a more robust effect on reward behavior and often cause effects like hypersexuality. That leaves you with pramipexole (Mirapex) and ropinirole (Requip). You will see both of these advertised on TV for restless legs syndrome. If you can get a psychiatrist to prescribe one or the other it might be worth a shot. The only downside that has prevented me from trying one is that they cause drowsiness and I'm already very fatigued. BTW cabergoline (Dostinex) has been associated with fibrotic tumors. All the ergot-derived agonists carry this effect, but cabergoline much more so. Pramipexole and ropinirole are fully synthetic and non-ergot derivitives and have no reports of this effect.

>

> My prolactin seems to be low enough (5 vs the normal range of 2-18), so does it make sense for a few doses of dostinex? If I'm leaning towards using a dopamine agonist, is it possible that Dostinex might still work even though prolactin is already low?

>