Re: reverses and prevents fluoxetine-induced sexual dysfunction in rats.

[Guest guest]

Wow!  Someone noticed that

there's a problem with SSRI's!  Where do we get 5-HT(1A)

antagonists?

 

Hi, while looking for more information on our problem I

found this:

5-HT(1A) receptor antagonism reverses and prevents

fluoxetine-induced sexual dysfunction in rats.

http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Is this of any use to us?

--

"If we do not change our direction we are likely to end up where

we are headed." Chinese Proverb

[Guest guest]

This is an interesting abstract. The research is actually being done by Wyeth

Research, which is a drug company that is now part of pfizer.

These are new drugs being tested so you cannot get them today. It is promising

though to see that there is current research going on to make meds to address

ssri sexual dysfunction. Keep in mind these are for sexual dysfunction while on

the SSRIs but it is possible they could help with PSSD as well.

This was published in 2009 and is only a study on rats. Keep this in mind.

These drug candidates will need to go through 3 phases of clinical trials once

large animal trials are done too. They will need to be proven safe (at least

moderately so) and effective.

None the less its good news but I doubt you will see these available for another

few years at least.

>

> Hi, while looking for more information on our problem I found this:

>

> 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual

dysfunction in rats.

>

>

http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.P\

Entrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

>

> Is this of any use to us?

>

[Guest guest]

Guys...

Don't try evry medication you can find. Also stop looking on the internet for

the problem.

Things DO get better, i'm an example of this.

My condition was:

a) Not beïng able to get a erection, could hardly masturbate

No sensation at all, didn't even feel an orgasm.

c) I've feeled lots worse after ejaculation.

There is nothing of medication you can take to reverse the problem.

I've tried: Wellbutrin, stablon, mirtazapine, moclobemide.

Noting worked. Sometimes yes there is a improvement in some symptoms, but

worsening in others.

I can imagine you guys want to have sex. Try viagra, Cialis, Levitra.

They don't alter the problem, but makes you able to have sex (this is what

evrybody is stressing about).

Now I can (after 12 mounths absent):

a) Get an erection

Feel some fun in masturbating

c) Get a small rush of pleasure during orgasm.

To answer your question:

Periactin. It's a serotonin antagonist. Used for alergies & serotonin syndrome.

Seems to help temporarly from what i've read.

Maybe this + erectile dysfunction agent should give some relief

>

> Hi, while looking for more information on our problem I found this:

>

> 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual

dysfunction in rats.

>

>

http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.P\

Entrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

>

> Is this of any use to us?

>

[Guest guest]

I disagree that what's stressing

people here is the inability to have sex (and you must be

speaking of men, since women, as we've been told, can lie back

& think of England and thus "have sex").  I think everyone

here wants their sexuality back: libido, arousal, physical

enjoyment of intercourse, and bomb-shelter orgasms.

Just because Wellbutrin, stablon, mirtazapine, and moclobemide

didn't work for you doesn't mean one of those won't work for somebody.

Also I disagree about not looking for solutions on the Web. 

Someone discovered Periactin on the Web, and you haven't

rejected it, so even you must feel that Web research has some

value.

Ann

 

Guys...

Don't try evry medication you can find. Also stop looking

on the internet for the problem.

Things DO get better, i'm an example of this.

My condition was:

a) Not be�ng able to get a erection, could hardly

masturbate

No sensation at all, didn't even feel an orgasm.

c) I've feeled lots worse after ejaculation.

There is nothing of medication you can take to reverse the

problem.

I've tried: Wellbutrin, stablon, mirtazapine, moclobemide.

Noting worked. Sometimes yes there is a improvement in

some symptoms, but worsening in others.

I can imagine you guys want to have sex. Try viagra,

Cialis, Levitra.

They don't alter the problem, but makes you able to have

sex (this is what evrybody is stressing about).

Now I can (after 12 mounths absent):

a) Get an erection

Feel some fun in masturbating

c) Get a small rush of pleasure during orgasm.

To answer your question:

Periactin. It's a serotonin antagonist. Used for alergies

& serotonin syndrome.

Seems to help temporarly from what i've read.

Maybe this + erectile dysfunction agent should give some

relief

>

> Hi, while looking for more information on our problem

I found this:

>

> 5-HT(1A) receptor antagonism reverses and prevents

fluoxetine-induced sexual dysfunction in rats.

>

> http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

>

> Is this of any use to us?

>

--

"If we do not change our direction we are likely to end up where

we are headed." Chinese Proverb

[Guest guest]

Everybody is stressing about whatever they have lost. We have not all lost the

exact same things. The men who can no longer get erections, are suffering

over this.

A lot of people have lost their emotions as well... this is a complex situation,

and very difficult for everybody to live with.

I am a woman by the way. And this has been pretty tragic in my life so far.

> > >

> > > Hi, while looking for more information on our problem I found this:

> > >

> > > 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced

sexual dysfunction in rats.

> > >

> > >

> >

http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.P\

Entrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

> >

<http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.\

PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>

> > >

> > > Is this of any use to us?

> > >

> >

> >

>

> --

> " If we do not change our direction we are likely to end up where we are

headed. " Chinese Proverb

>

[Guest guest]

That's true. Deep inside I know the only thing that is going to actually heal

the problem is time. And yes I believe there are temporary fixes.

I've read a lot of succes stories, and I'm hanging on to that.

I may only speak for myself but the problem can be obsessing. I miss all sorts

off fun stuff when my mind gets occupied with PSSD.

Now i've noticed that my problem gets worse. Is it because i've started with

300mg moclobemide and 2,5mg of zyprexa/dag or is it because i'm getting more and

more depressed or is it because i'm obsessing again about the problem, I don't

know.

This sertainly isn't due to the SSRI's

And speaking like I feel now (not so bad actually ) I am going to get me some

dostinex AND Periactin! (more like a hell yea i'm going to fight this creature!)

Me.

> > >

> > > Hi, while looking for more information on our problem I found this:

> > >

> > > 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced

sexual dysfunction in rats.

> > >

> > >

> >

http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.P\

Entrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

> >

<http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.\

PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>

> > >

> > > Is this of any use to us?

> > >

> >

> >

>

> --

> " If we do not change our direction we are likely to end up where we are

headed. " Chinese Proverb

>

[Guest guest]

That's true. Deep inside I know the only thing that is going to actually heal

the problem is time. And yes I believe there are temporary fixes.

I've read a lot of succes stories, and I'm hanging on to that.

I may only speak for myself but the problem can be obsessing. I miss all sorts

off fun stuff when my mind gets occupied with PSSD.

Now i've noticed that my problem gets worse. Is it because i've started with

300mg moclobemide and 2,5mg of zyprexa/dag or is it because i'm getting more and

more depressed or is it because i'm obsessing again about the problem, I don't

know.

This sertainly isn't due to the SSRI's

And speaking like I feel now (not so bad actually ) I am going to get me some

dostinex AND Periactin! (more like a hell yea i'm going to fight this creature!)

Me.

> > >

> > > Hi, while looking for more information on our problem I found this:

> > >

> > > 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced

sexual dysfunction in rats.

> > >

> > >

> >

http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.P\

Entrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

> >

<http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.\

PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>

> > >

> > > Is this of any use to us?

> > >

> >

> >

>

> --

> " If we do not change our direction we are likely to end up where we are

headed. " Chinese Proverb

>

[Guest guest]

Zyprexa is what triggered my ejaculatory anhedonia after 2 days of

taking the 2.5mg dose. I have yet to recover and it has been over 11

months. I got off the cymbalta shortly after the zyprexa as well

once I discovered SSRIsex while researching my devastating

condition . The zyprexa caused general anhedonia as well. I have no

normal emotional response or feeling to anything. I also feel no

anxiety even though my entire life is falling apart around me.

Please

beware of zyprexa! Based on all I have been checked for over the

last year it seems it messed up my hormones or how my livers

processes them almost overnite.

That's true. Deep inside I know the only thing that is

going to actually heal the problem is time. And yes I

believe there are temporary fixes.

I've read a lot of succes stories, and I'm hanging on to

that.

I may only speak for myself but the problem can be

obsessing. I miss all sorts off fun stuff when my mind

gets occupied with PSSD.

Now i've noticed that my problem gets worse. Is it because

i've started with 300mg moclobemide and 2,5mg of

zyprexa/dag or is it because i'm getting more and more

depressed or is it because i'm obsessing again about the

problem, I don't know.

This sertainly isn't due to the SSRI's

And speaking like I feel now (not so bad actually ) I am

going to get me some dostinex AND Periactin! (more like a

hell yea i'm going to fight this creature!)

Me.

> > >

> > > Hi, while looking for more information on

our problem I found this:

> > >

> > > 5-HT(1A) receptor antagonism reverses and

prevents fluoxetine-induced sexual dysfunction in rats.

> > >

> > >

> > http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

> > <http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>

> > >

> > > Is this of any use to us?

> > >

> >

> >

>

> --

> "If we do not change our direction we are likely to

end up where we are headed." Chinese Proverb

>

No virus found in

this message.

Checked by AVG - www.avg.com

Version: 10.0.1153 / Virus Database: 424/3271 - Release Date:

11/21/10