Guest guest Posted December 6, 2009 Report Share Posted December 6, 2009 translate by google: Paradoxically, reduced initiation of therapy with SSRIs, the desired 5-HT concentrations increase by a different effect. The flooding first high serotonin levels in the synaptic cleft while the Auto presynaptic receptors that serve the cell as a feedback sensor. The activation of the autoreceptors (by agonists such as serotonin) in the cell triggers the signal for a decrease of serotonin production. The thereby resulting serotonin deficiency persists in the totals, since the transporter inhibition is just downstream and does not eliminate the shortage. In the ongoing receptor stimulation of the body responds by lowering the sensitivity (sensitivity) of the car receptors (somatodendritische 5-HT 1A and terminal 5-HT 1D) [1]. This process may take several weeks. Also, the number / density of 5-HT1 receptors decreases [1]. A similar adjustment process that has for the antidepressant effect of greater importance is the desired reduction in the number of serotonin-(5-HT) 2A receptors in the central nervous system. The sensitivity of postsynaptic 5-HT 1A and 2 receptors may increase. [1] These phenomena are likely to be a significant antidepressant effect and could explain why a sustained antidepressant effect comes only after weeks of pharmacotherapy to full fruition. -------------------------------------------------------------------- reverse this action: raise up: 5HT1, 5HT1a, 5HT1d, ( with an antagonist ) raise up: 5HT2a in the central nerous system ( with an agonist ? ) raise up: dopamin ? http://en.wikipedia.org/wiki/5-HT_receptor#Subtypes http://www.ncbi.nlm.nih.gov/pubmed/19435548?ordinalpos=130 & itool=EntrezSystem2.P\ Entrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum > > has anyone tried " antidotes " ? I read an article or study of some people with PSSD who resolved taking Amineptine. I read other article about taking Buspiron. > > would antidotes for non-PSSD sexual dysfunction while still taking SSRI work for PSSD? > in this case, I read that Nefazodone didn't work, and Bupoprion didn't work to me. > > if we are mentally ill, and our condition is unreversible, I'd not care taking medications for the rest of my life. this is the only solution for " mental illness " . > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 14, 2009 Report Share Posted December 14, 2009 There is some evidence that 5-HT1A antagonists could be working as 'antidotes': http://www.ncbi.nlm.nih.gov/pubmed/19435548 After I searched the Web about this I think Lecozotan is the drug which is possibly available next (in Phase III of clinical trials): http://en.wikipedia.org/wiki/Lecozotan Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 14, 2009 Report Share Posted December 14, 2009 thank you !!! > > There is some evidence that 5-HT1A antagonists could be working as 'antidotes': > > http://www.ncbi.nlm.nih.gov/pubmed/19435548 > > After I searched the Web about this I think Lecozotan is the drug which is possibly available next (in Phase III of clinical trials): > > http://en.wikipedia.org/wiki/Lecozotan > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 14, 2009 Report Share Posted December 14, 2009 Antidotes for what? Sent from my iPhone Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 14, 2009 Report Share Posted December 14, 2009 Thanks for this post! I certainly hope this gives even more hope to all of us suffering from this awful affliction. I'm curious though, what are some names of 5-HT1A antagonists? Have any of you out there taken any of these? Any luck? I'd personally be willing to try this... -M > > There is some evidence that 5-HT1A antagonists could be working as 'antidotes': > > http://www.ncbi.nlm.nih.gov/pubmed/19435548 > > After I searched the Web about this I think Lecozotan is the drug which is possibly available next (in Phase III of clinical trials): > > http://en.wikipedia.org/wiki/Lecozotan > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 15, 2009 Report Share Posted December 15, 2009 There are some 5-ht1a antagonists listed here. http://en.wikipedia.org/wiki/5-ht_receptor > > > > There is some evidence that 5-HT1A antagonists could be working as 'antidotes': > > > > http://www.ncbi.nlm.nih.gov/pubmed/19435548 > > > > After I searched the Web about this I think Lecozotan is the drug which is possibly available next (in Phase III of clinical trials): > > > > http://en.wikipedia.org/wiki/Lecozotan > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 16, 2009 Report Share Posted December 16, 2009 hi, another interesting abstract (older) in respect of 5-HT1A receptors: " The conclusion was made that the 5-HT(1A) subtype is involved in controlling both behavioral and hormonal indices of sexual arousal in male mice... " http://www.ncbi.nlm.nih.gov/pubmed/11965359 Behavioral and hormonal! > > > > There is some evidence that 5-HT1A antagonists could be working as 'antidotes': > > > > http://www.ncbi.nlm.nih.gov/pubmed/19435548 > > > > After I searched the Web about this I think Lecozotan is the drug which is possibly available next (in Phase III of clinical trials): > > > > http://en.wikipedia.org/wiki/Lecozotan > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 19, 2009 Report Share Posted December 19, 2009 Has anyone on here attempted to use any of these so-called antidotes? Does anyone have anything to report? Just curious... I myself have never tried any of them, but I'm considering it. Thanks! -M > > > > > > There is some evidence that 5-HT1A antagonists could be working as 'antidotes': > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/19435548 > > > > > > After I searched the Web about this I think Lecozotan is the drug which is possibly available next (in Phase III of clinical trials): > > > > > > http://en.wikipedia.org/wiki/Lecozotan > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 21, 2009 Report Share Posted December 21, 2009 Is there even any way to get them? > > > > > > > > There is some evidence that 5-HT1A antagonists could be working as 'antidotes': > > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/19435548 > > > > > > > > After I searched the Web about this I think Lecozotan is the drug which is possibly available next (in Phase III of clinical trials): > > > > > > > > http://en.wikipedia.org/wiki/Lecozotan > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 22, 2010 Report Share Posted February 22, 2010 Try Cognitive Behavioral Therapy and consider tapering off your SSRI gradually. > would antidotes for non-PSSD sexual dysfunction while still taking SSRI work for PSSD? > in this case, I read that Nefazodone didn't work, and Bupoprion didn't work to me. > > if we are mentally ill, and our condition is unreversible, I'd not care taking medications for the rest of my life. this is the only solution for " mental illness " . Quote Link to comment Share on other sites More sharing options...
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