Severe reactions with dtp vax: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying

[Guest guest]

This is NOT acceptable.

60 children..why wasn't it withdrawn or were these children expendable?

Pediatrics. 1993 Jun;91(6):1158-65. Related Articles, Links

Comment in:

a.. Pediatrics. 1994 Jan;93(1):154-5.

Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed

study of children with seizures, hypotonic-hyporesponsive episodes, high fevers,

and persistent crying.

Blumberg DA, K, Mink CM, Christenson PD, Chatfield P, Cherry JD.

Dept of Pediatrics, UCLA School of Medicine 90024-1752.

OBJECTIVE. The pathophysiology of severe reactions to

diphtheria-tetanus-pertussis (DTP)vaccine is not well understood. Active

pertussis toxin in DTP vaccine has been proposed to cause severe DTP vaccine

reactions. Large doses of pertussis toxin cause hyperinsulinemia and

hypoglycemia as well as leukocytosis with a predominant lymphocytosis in animal

models. To learn more about the causes of and risk factors for severe DTP

vaccine reactions, children experiencing severe DTP vaccine reactions were

studied. DESIGN. Prospective, referral-based surveillance. SETTING. Los Angeles,

CA. SUBJECTS. Children experiencing severe reactions within 48 hours of DTP

immunization and evaluated within 24 hours of the reaction. Severe reactions

included encephalopathy, persistent crying > or = 3 hours,

hypotonic-hyporesponsive episodes (collapse episodes), fever > or = 40.5 degrees

C, or seizures. Some comparisons were made between children with DTP

vaccine-associated seizures and a comparison group of children experiencing

febrile seizures unrelated to immunization. OUTCOME MEASURES. A history and

physical examination were performed. Follow-up examinations were performed 1

month later. Blood was collected for complete blood cell count with leukocyte

differential count, serum chemistry measurements, and insulin and glucose

values. Serum was assayed for active pertussis toxin, both in free and

immune-complex masked states. RESULTS. Sixty children experienced severe

reactions within 48 hours of DTP immunization: 32 children had seizures only, 14

subjects had hypotonic-hyporesponsive episodes, 2 subjects had fever > or = 40.5

degrees C only, 4 subjects had persistent crying > or = 3 hours, 6 children had

seizures and fever > or = 40.5 degrees C, and 2 children had persistent crying

and seizures. The children with seizures had a high rate of personal and family

histories of seizures, and 90% had documented fevers (> or = 38 degrees C).

Persistent crying was associated with painful local reactions. Effects that may

have been due to vaccine pertussis toxin were not found. Lymphocytosis did not

occur, nor did hypoglycemia. Some relatively elevated insulin values were noted;

however, this finding was also noted in the comparison group of children

experiencing febrile seizures unrelated to immunization. No biologically active

pertussis toxin was found in the acute sera of children experiencing severe DTP

vaccine reactions. CONCLUSIONS. Seizures associated with DTP vaccine have

similar clinical characteristics as febrile seizures, and persistent crying is

initiated by painful local reactions. Vaccine endotoxin is a cause of febrile

DTP vaccine reactions. We found no evidence that DTP vaccine pertussis toxin

plays a role in severe DTP vaccine reactions.

MeSH Terms:

a.. Anaphylaxis/etiology

b.. Blood Glucose/analysis

c.. Child

d.. Child, Preschool

e.. Crying

f.. Diphtheria-Tetanus-Pertussis Vaccine/adverse effects*

g.. Fever/etiology

h.. Humans

i.. Infant

j.. Insulin/blood

k.. Muscle Hypotonia/etiology

l.. Pertussis Toxin

m.. Prospective Studies

n.. Research Support, Non-U.S. Gov't

o.. Research Support, U.S. Gov't, P.H.S.

p.. Seizures/etiology

q.. Virulence Factors, Bordetella/adverse effects

r.. Virulence Factors, Bordetella/blood

Substances:

a.. Blood Glucose

b.. Diphtheria-Tetanus-Pertussis Vaccine

c.. Virulence Factors, Bordetella

d.. Insulin

e.. Pertussis Toxin

Grant Support:

a.. DMID-91-33/PHS

PMID: 8502521 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

[Guest guest]

There is a long, lucrative tradition of MDs and professors twinking

findings and rhetoric describing the findings for the purpose of

" disappearing " adverse reactions to vaccinations. Thus, when the CDC

found adverse reactions to thimerosal injections (CDC 1999), the CDC

data-dilutions and subsequent publishing of diluted-data was consistent

with a long tradition of sweeping under the rug the findings that

contradicted vaccine orthodoxy's soothing tho' non-truthful rhetoric.

When the IOM contractually kowtowed to the CDC directive to whitewash

thimerosal's adverse reactions, Marie McCormick and her staff of willing

collusionists were merely " doing their job " and acted in willing accord

with the long, lucrative tradition of MDs and professors twinking

findings and rhetoric describing the findings for the purpose of

" disappearing " adverse reactions to vaccinations.

JULIE GRIFFITHS wrote:

>This is NOT acceptable.

>

>60 children..why wasn't it withdrawn or were these children expendable?

>

>

>

>

> Pediatrics. 1993 Jun;91(6):1158-65. Related Articles, Links

>

>

>Comment in:

> a.. Pediatrics. 1994 Jan;93(1):154-5.

>

>Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed

study of children with seizures, hypotonic-hyporesponsive episodes, high fevers,

and persistent crying.

>

>Blumberg DA, K, Mink CM, Christenson PD, Chatfield P, Cherry JD.

>

>Dept of Pediatrics, UCLA School of Medicine 90024-1752.

>

>OBJECTIVE. The pathophysiology of severe reactions to

diphtheria-tetanus-pertussis (DTP)vaccine is not well understood. Active

pertussis toxin in DTP vaccine has been proposed to cause severe DTP vaccine

reactions. Large doses of pertussis toxin cause hyperinsulinemia and

hypoglycemia as well as leukocytosis with a predominant lymphocytosis in animal

models. To learn more about the causes of and risk factors for severe DTP

vaccine reactions, children experiencing severe DTP vaccine reactions were

studied. DESIGN. Prospective, referral-based surveillance. SETTING. Los Angeles,

CA. SUBJECTS. Children experiencing severe reactions within 48 hours of DTP

immunization and evaluated within 24 hours of the reaction. Severe reactions

included encephalopathy, persistent crying > or = 3 hours,

hypotonic-hyporesponsive episodes (collapse episodes), fever > or = 40.5 degrees

C, or seizures. Some comparisons were made between children with DTP

vaccine-associated seizures and a comparison group of children experiencing

febrile seizures unrelated to immunization. OUTCOME MEASURES. A history and

physical examination were performed. Follow-up examinations were performed 1

month later. Blood was collected for complete blood cell count with leukocyte

differential count, serum chemistry measurements, and insulin and glucose

values. Serum was assayed for active pertussis toxin, both in free and

immune-complex masked states. RESULTS. Sixty children experienced severe

reactions within 48 hours of DTP immunization: 32 children had seizures only, 14

subjects had hypotonic-hyporesponsive episodes, 2 subjects had fever > or = 40.5

degrees C only, 4 subjects had persistent crying > or = 3 hours, 6 children had

seizures and fever > or = 40.5 degrees C, and 2 children had persistent crying

and seizures. The children with seizures had a high rate of personal and family

histories of seizures, and 90% had documented fevers (> or = 38 degrees C).

Persistent crying was associated with painful local reactions. Effects that may

have been due to vaccine pertussis toxin were not found. Lymphocytosis did not

occur, nor did hypoglycemia. Some relatively elevated insulin values were noted;

however, this finding was also noted in the comparison group of children

experiencing febrile seizures unrelated to immunization. No biologically active

pertussis toxin was found in the acute sera of children experiencing severe DTP

vaccine reactions. CONCLUSIONS. Seizures associated with DTP vaccine have

similar clinical characteristics as febrile seizures, and persistent crying is

initiated by painful local reactions. Vaccine endotoxin is a cause of febrile

DTP vaccine reactions. We found no evidence that DTP vaccine pertussis toxin

plays a role in severe DTP vaccine reactions.

>

>

>

[Guest guest]

> This is NOT acceptable.

>

> 60 children..why wasn't it withdrawn or were these children

expendable?

>

>

>

The women I know whose children had a reaction to DPT and thier

children went on to develop Lennox Gastaut, Thier infants had a

seizure after the injection. (When I say reaction to DPT... That

means it is documented)I think the women who " catch " thier child in

a seizure, Know what to look for.

I had never seen anyone have a seizure until my son had them. When

was 22 months old, (he had already been diagnosed with various

problems) was not feeling well, I just felt like something was

really wrong, So I called my sister in law up and ask her to come

over, She brought my brother in law with her, I had in my arms

and when I opened the door, My brother in law looked at and

said hes in a seizure(one of his siblings has seizures) We rushed

to the hospital, As soon as we walked in the door, went

rag doll, I handed him to the nurse she ran to the back and shortly

after came through. The hospital was getting his papers

together to release him, But one of the nurses kept walking by

checking on told the doctor hes still having seizures. So they

admitted , Finally about 11 at night, s Pediatrican shows

up, Im holding on my lap with facing the doctor, s

Ped. kept looking at his watch, I was getting very annoyed and

thought how rude of him to be worried about the time, Then

went rag doll again, The doctor jumped and checked s heart. The

Ped was timing a seizure was having. Here he was in a seizure

while I was holding him and I didnt even know he was having it.

s first EEG, was being fussy and moving around, I thought

was annoyed so I tried to calm him down, The EEG Technician

said, You cant help him, hes in a middle of a seizure. did

this a lot at home. So, when did have his first seizure, I

have no idea. He always arched his back, This is very frustraing

when you are holding an infant and all of a sudden they do this. The

crying for hours, Like all moms I was told this was " colic " Of

course nothing worked to rid of " colic " .

Infantile Spasms, I wonder how many infants actually have this. I

some out grow the infantile spasams, Some go on to develop Lennox

Gastaut.

On one of s hospital stays for uncontrollable seizures,(By this

point I know what seizures are.) s Neuro comes in the room with

5 Neuro interns, s Neuro ask me if I would point out the

diffrent seizures has to the interns. Here I am going from

not ever seeing a seizure to showing Neuro interns what seizures

look like.

How many infants have undiagnose infantile spasms?

60, children....I dont think so.