Re: My son turns yellow - Diane

[Guest guest]

Hello Diane, I just wanted to let you know that my little guy has been retested and his "turning yellow" remains officially a mystery. He is not yellow at the moment but he had changed color twice so when I asked about other parents' experiences, I wanted to know what i could do to prevent the next occurence, should there be one. When he was tested the first time, he was yellow at the time and nothing abnormal was found. The second series of tests were done while he was back to normal and again, nothing found. I believe in the possibility that it was some kind of a toxic buildup and when he was able to release some of it, he went back to normal. I don't know, I'm just trying to figure it out. We are big on epsom salts baths now which we weren't previously. I'm sure it's helping. Also, we are now strict SCD and the color change was prior to that diet. He

has yellow hands and feet still but he's been this way for about a year. Our doc has absolutely no explanation or even a theory. His urine has always remained very clear. Thank you so much for your concern and advice. It is always very appreciated. Stéphanie B.diatplay wrote: I hope you see this post, and take it seriously. Get a liver check ASAP AGAIN. I mean that. Do not make an appointment with a doctor - even if you really like

yours. Do not waste time....go immediatly and have his liver looked at again bc turning bright Homer Simpson yellow IS a sign of something afoot in the liver. My friend who died - sorry to scare you but you need to take this very seriously - of pancreatic cancer was bright yellow when admitted to Cedar Sinai Hospital in Los Angeles. Also his urine turned the color of coca cola. PLEASE go immediatly to a good hospital, not county if you know what I mean, and have him admitted for a better more thorough analysis of his symptoms. Use the urgent care if you need to but try and go to a hospital where their are specialists on staff if you are allowed to choose...I would not see your doctor and just leave it at that. Something is very wrong with what you just described, and your post alarms me. Please have him looked at again, and at a hospital staffed with people who know all about the liver and diseases that can affect

it...that way when THEY clear him, you know he is really in the clear. A drastic change in appearance with discomfort and whining is NOT okay - your doctor is missing something that specialists may be able to help you understand. I am hoping that it turns out to be something harmless. I would go where second third and fourth opinions are all in the same building though if this were my child. Please let us know. LOL. Di> >> > Hello everyone,> > > > My son's feet have been a noticeable golden yellow for some time.> His hands as well but not as bad. Then suddenly, his whole body went> yellow. I mean REALLY yellow. So we rushed him for some blood tests> to check his liver and kidneys and everything was just fine, including> bilirubin. Our doctor couldn't figure it out either. Then he went> back to normal for about two weeks, except for his feet. Then it> happened again. He went orange for one day and then practically> glow-in-the-dark yellow again for about 5 days. Then back to normal.> Both times he seemed exhausted and whiny. > > > > Anybody experience this? Any ideas as to what's happening to him?>

> > > Thanks in advance,> > > > Stéphanie B.> > > > > > ---------------------------------> > Be a better sports nut! Let your teams follow you with Yahoo Mobile.> Try it now.> >> > > > > > > > > > ---------------------------------> Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.>

Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.

[Guest guest]

my son did this with liver stress and high carrot and yellow and orange pepper intake

Re: Re: My son turns "yellow" - Diane

Hello Diane,

I just wanted to let you know that my little guy has been retested and his "turning yellow" remains officially a mystery. He is not yellow at the moment but he had changed color twice so when I asked about other parents' experiences, I wanted to know what i could do to prevent the next occurence, should there be one. When he was tested the first time, he was yellow at the time and nothing abnormal was found. The second series of tests were done while he was back to normal and again, nothing found.

I believe in the possibility that it was some kind of a toxic buildup and when he was able to release some of it, he went back to normal. I don't know, I'm just trying to figure it out. We are big on epsom salts baths now which we weren't previously. I'm sure it's helping. Also, we are now strict SCD and the color change was prior to that diet. He has yellow hands and feet still but he's been this way for about a year. Our doc has absolutely no explanation or even a theory. His urine has always remained very clear.

Thank you so much for your concern and advice. It is always very appreciated.

Stéphanie B.diatplay <diatplay> wrote:

I hope you see this post, and take it seriously. Get a liver check ASAP AGAIN. I mean that. Do not make an appointment with a doctor - even if you really like yours. Do not waste time....go immediatly and have his liver looked at again bc turning bright Homer Simpson yellow IS a sign of something afoot in the liver. My friend who died - sorry to scare you but you need to take this very seriously - of pancreatic cancer was bright yellow when admitted to Cedar Sinai Hospital in Los Angeles. Also his urine turned the color of coca cola. PLEASE go immediatly to a good hospital, not county if you know what I mean, and have him admitted for a better more thorough analysis of his symptoms. Use the urgent care if you need to but try and go to a hospital where their are specialists on staff if you are allowed to choose...I would not see your doctor and just leave it at that. Something is very wrong with what you just described, and your post alarms me. Please have him looked at again, and at a hospital staffed with people who know all about the liver and diseases that can affect it...that way when THEY clear him, you know he is really in the clear. A drastic change in appearance with discomfort and whining is NOT okay - your doctor is missing something that specialists may be able to help you understand. I am hoping that it turns out to be something harmless. I would go where second third and fourth opinions are all in the same building though if this were my child. Please let us know. LOL. Di> >> > Hello everyone,> > > > My son's feet have been a noticeable golden yellow for some time.> His hands as well but not as bad. Then suddenly, his whole body went> yellow. I mean REALLY yellow. So we rushed him for some blood tests> to check his liver and kidneys and everything was just fine, including> bilirubin. Our doctor couldn't figure it out either. Then he went> back to normal for about two weeks, except for his feet. Then it> happened again. He went orange for one day and then practically> glow-in-the-dark yellow again for about 5 days. Then back to normal.> Both times he seemed exhausted and whiny. > > > > Anybody experience this? Any ideas as to what's happening to him?> > > > Thanks in advance,> > > > Stéphanie B.> > > > > > ---------------------------------> > Be a better sports nut! Let your teams follow you with Yahoo Mobile.> Try it now.> >> > > > > > > > > > ---------------------------------> Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.>

Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.

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[Guest guest]

I am SO relieved - thank you for posting despite how busy this

disease keeps us all. Babies are often yellow when they are born and

the remedy is to put them in sunlight...I do not think it is their

livers...so perhaps they turn this color for the same reason as your

son...and sunlight ( vitamin D? ) is the cure for jaundiced babies as

far as I know....LOL Di

> > >

> > > Hello everyone,

> > >

> > > My son's feet have been a noticeable golden yellow for some

time.

> > His hands as well but not as bad. Then suddenly, his whole body

went

> > yellow. I mean REALLY yellow. So we rushed him for some blood

tests

> > to check his liver and kidneys and everything was just fine,

> including

> > bilirubin. Our doctor couldn't figure it out either. Then he went

> > back to normal for about two weeks, except for his feet. Then it

> > happened again. He went orange for one day and then practically

> > glow-in-the-dark yellow again for about 5 days. Then back to

normal.

> > Both times he seemed exhausted and whiny.

> > >

> > > Anybody experience this? Any ideas as to what's happening to

him?

> > >

> > > Thanks in advance,

> > >

> > > Stéphanie B.

> > >

> > >

> > > ---------------------------------

> > > Be a better sports nut! Let your teams follow you with Yahoo

> Mobile.

> > Try it now.

> > >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> > ---------------------------------

> > Be a better sports nut! Let your teams follow you with Yahoo

> Mobile. Try it now.

> >

>

>

>

>

>

>

> ---------------------------------

> Be a better sports nut! Let your teams follow you with Yahoo

Mobile. Try it now.

>

[Guest guest]

I was told that vegetables high in the glycemic index, like carrots, bananas etc. will turn to starch and the making of glucose will put strain on the liver...Christel King wrote: my son did this with liver stress and high carrot and yellow and orange pepper intake Re: Re: My son turns "yellow" - Diane Hello Diane, I just wanted to let you know that my little guy has been retested and his "turning yellow" remains officially a mystery. He is not yellow at the moment but he had changed color twice so when I asked about other parents' experiences, I wanted to know what i could do to prevent the next occurence, should there be one. When he was tested the first time, he was yellow at the time and nothing abnormal was

found. The second series of tests were done while he was back to normal and again, nothing found. I believe in the possibility that it was some kind of a toxic buildup and when he was able to release some of it, he went back to normal. I don't know, I'm just trying to figure it out. We are big on epsom salts baths now which we weren't previously. I'm sure it's helping. Also, we are now strict SCD and the color change was prior to that diet. He has yellow hands and feet still but he's been this way for about a year. Our doc has absolutely no explanation or even a theory. His urine has always remained very clear. Thank you so much for your concern and advice. It is always very appreciated. Stéphanie B.diatplay <diatplay> wrote: I hope you see this post, and take it seriously. Get a liver check ASAP AGAIN. I mean that. Do not make an appointment with a doctor - even if you really like yours. Do not waste time....go immediatly and have his liver looked at again bc turning bright Homer Simpson yellow IS a sign of something afoot in the liver. My friend who died - sorry to scare you but you need to take this very seriously - of pancreatic cancer was bright yellow when admitted to Cedar Sinai Hospital in Los Angeles. Also his urine turned the color of coca cola. PLEASE go immediatly to a good hospital, not county if you know what I mean, and have him admitted for a better more thorough analysis of his symptoms. Use the urgent care if you need to but try and go to a hospital where their are specialists on staff if you are allowed to choose...I would not see your doctor and just leave it at that.

Something is very wrong with what you just described, and your post alarms me. Please have him looked at again, and at a hospital staffed with people who know all about the liver and diseases that can affect it...that way when THEY clear him, you know he is really in the clear. A drastic change in appearance with discomfort and whining is NOT okay - your doctor is missing something that specialists may be able to help you understand. I am hoping that it turns out to be something harmless. I would go where second third and fourth opinions are all in the same building though if this were my child. Please let us know. LOL. Di> >> > Hello everyone,> > > > My son's feet have been a noticeable golden yellow for some time.> His hands as well but not as bad. Then suddenly, his whole body went> yellow. I mean REALLY yellow. So we rushed him for some blood tests> to check his liver and kidneys and everything was just fine, including> bilirubin. Our doctor couldn't figure it out either. Then he went> back to normal for about two weeks, except for his feet. Then it> happened again. He went orange for one day and then practically> glow-in-the-dark yellow again for about 5 days. Then back to normal.>

Both times he seemed exhausted and whiny. > > > > Anybody experience this? Any ideas as to what's happening to him?> > > > Thanks in advance,> > > > Stéphanie B.> > > > > > ---------------------------------> > Be a better sports nut! Let your teams follow you with Yahoo Mobile.> Try it now.> >> > > > > > > > > > ---------------------------------> Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.> Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.

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[Guest guest]

Eliminate casein, starchy like crackers, sweets right away. Most kids with autism are anemic. Google for iron-rich foods and buy organic. May give temp highly-absorbable iron like Feosol Carbonyl (just google'd Mercola). Don't even dare delay or take it lightly what your child has been TELLING YOU Ann Jeanne Colla wrote: I was told that vegetables high in the glycemic index, like carrots, bananas etc. will turn

to starch and the making of glucose will put strain on the liver...Christel King <christelking1verizon (DOT) net> wrote: my son did this with liver stress and high carrot and yellow and orange pepper intake Re:

Re: My son turns "yellow" - Diane Hello Diane, I just wanted to let you know that my little guy has been retested and his "turning yellow" remains officially a mystery. He is not yellow at the moment but he had changed color twice so when I asked about other parents' experiences, I wanted to know what i could do to prevent the next occurence, should there be one. When he was tested the first time, he was yellow at the time and nothing abnormal was found. The second series of tests were done while he was back to normal and again, nothing found. I believe in the possibility that it was some kind of a toxic buildup and when he was able to release some of it, he went back to normal. I don't know, I'm just trying to figure it out. We are big on epsom salts baths now which we weren't previously. I'm sure

it's helping. Also, we are now strict SCD and the color change was prior to that diet. He has yellow hands and feet still but he's been this way for about a year. Our doc has absolutely no explanation or even a theory. His urine has always remained very clear. Thank you so much for your concern and advice. It is always very appreciated. Stéphanie B.diatplay <diatplay> wrote: I hope you see this post, and take it seriously. Get a liver check ASAP AGAIN. I mean that. Do not make an appointment with a doctor - even if you really like yours. Do not waste time....go immediatly and have his liver looked at again bc turning bright Homer Simpson yellow IS a sign of something afoot in the liver. My friend who died - sorry to scare

you but you need to take this very seriously - of pancreatic cancer was bright yellow when admitted to Cedar Sinai Hospital in Los Angeles. Also his urine turned the color of coca cola. PLEASE go immediatly to a good hospital, not county if you know what I mean, and have him admitted for a better more thorough analysis of his symptoms. Use the urgent care if you need to but try and go to a hospital where their are specialists on staff if you are allowed to choose...I would not see your doctor and just leave it at that. Something is very wrong with what you just described, and your post alarms me. Please have him looked at again, and at a hospital staffed with people who know all about the liver and diseases that can affect it...that way when THEY clear him, you know he is really in the clear. A drastic change in appearance with discomfort and whining is NOT okay - your doctor is missing something that specialists

may be able to help you understand. I am hoping that it turns out to be something harmless. I would go where second third and fourth opinions are all in the same building though if this were my child. Please let us know. LOL. Di> >> > Hello everyone,> > > > My son's feet have been a noticeable golden

yellow for some time.> His hands as well but not as bad. Then suddenly, his whole body went> yellow. I mean REALLY yellow. So we rushed him for some blood tests> to check his liver and kidneys and everything was just fine, including> bilirubin. Our doctor couldn't figure it out either. Then he went> back to normal for about two weeks, except for his feet. Then it> happened again. He went orange for one day and then practically> glow-in-the-dark yellow again for about 5 days. Then back to normal.> Both times he seemed exhausted and whiny. > > > > Anybody experience this? Any ideas as to what's happening to him?> > > > Thanks in advance,> > > > Stéphanie B.> > > > > > ---------------------------------> > Be a better sports nut! Let your teams follow you with Yahoo Mobile.> Try it

now.> >> > > > > > > > > > ---------------------------------> Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.> Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now. No virus found in this incoming message.Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.16.11/1161 - Release Date: 11/30/2007 12:12 PM Never miss a thing. Make Yahoo

your homepage.

Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.

[Guest guest]

Please do not supplement iron w/out lab work and/or your doctor's direction. Giving too much iron can be dangerous especially if there is not a deficiency.

Dana

-----Original Message-----From: mb12 valtrex [mailto:mb12 valtrex ]On Behalf Of mary ann mendozaSent: Saturday, December 01, 2007 7:18 AMTo: mb12 valtrex Subject: Re: Re: My son turns "yellow" - Diane

Eliminate casein, starchy like crackers, sweets right away.

Most kids with autism are anemic.

Google for iron-rich foods and buy organic.

May give temp highly-absorbable iron like Feosol Carbonyl (just google'd Mercola). Don't even dare delay or take it lightly what your child has been TELLING YOU Ann

Jeanne Colla <jeanne_colla> wrote:

I was told that vegetables high in the glycemic index, like carrots, bananas etc. will turn to starch and the making of glucose will put strain on the liver...Christel King <christelking1verizon (DOT) net> wrote:

my son did this with liver stress and high carrot and yellow and orange pepper intake

Re: Re: My son turns "yellow" - Diane

Hello Diane,

I just wanted to let you know that my little guy has been retested and his "turning yellow" remains officially a mystery. He is not yellow at the moment but he had changed color twice so when I asked about other parents' experiences, I wanted to know what i could do to prevent the next occurence, should there be one. When he was tested the first time, he was yellow at the time and nothing abnormal was found. The second series of tests were done while he was back to normal and again, nothing found.

I believe in the possibility that it was some kind of a toxic buildup and when he was able to release some of it, he went back to normal. I don't know, I'm just trying to figure it out. We are big on epsom salts baths now which we weren't previously. I'm sure it's helping. Also, we are now strict SCD and the color change was prior to that diet. He has yellow hands and feet still but he's been this way for about a year. Our doc has absolutely no explanation or even a theory. His urine has always remained very clear.

Thank you so much for your concern and advice. It is always very appreciated.

Stéphanie B.diatplay <diatplay> wrote:

I hope you see this post, and take it seriously. Get a liver check ASAP AGAIN. I mean that. Do not make an appointment with a doctor - even if you really like yours. Do not waste time....go immediatly and have his liver looked at again bc turning bright Homer Simpson yellow IS a sign of something afoot in the liver. My friend who died - sorry to scare you but you need to take this very seriously - of pancreatic cancer was bright yellow when admitted to Cedar Sinai Hospital in Los Angeles. Also his urine turned the color of coca cola. PLEASE go immediatly to a good hospital, not county if you know what I mean, and have him admitted for a better more thorough analysis of his symptoms. Use the urgent care if you need to but try and go to a hospital where their are specialists on staff if you are allowed to choose...I would not see your doctor and just leave it at that. Something is very wrong with what you just described, and your post alarms me. Please have him looked at again, and at a hospital staffed with people who know all about the liver and diseases that can affect it...that way when THEY clear him, you know he is really in the clear. A drastic change in appearance with discomfort and whining is NOT okay - your doctor is missing something that specialists may be able to help you understand. I am hoping that it turns out to be something harmless. I would go where second third and fourth opinions are all in the same building though if this were my child. Please let us know. LOL. Di> >> > Hello everyone,> > > > My son's feet have been a noticeable golden yellow for some time.> His hands as well but not as bad. Then suddenly, his whole body went> yellow. I mean REALLY yellow. So we rushed him for some blood tests> to check his liver and kidneys and everything was just fine, including> bilirubin. Our doctor couldn't figure it out either. Then he went> back to normal for about two weeks, except for his feet. Then it> happened again. He went orange for one day and then practically> glow-in-the-dark yellow again for about 5 days. Then back to normal.> Both times he seemed exhausted and whiny. > > > > Anybody experience this? Any ideas as to what's happening to him?> > > > Thanks in advance,> > > > Stéphanie B.> > > > > > ---------------------------------> > Be a better sports nut! Let your teams follow you with Yahoo Mobile.> Try it now.> >> > > > > > > > > > ---------------------------------> Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.>

Be a better sports nut! Let your teams follow you with Yahoo Mobile. Try it now.

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[Guest guest]

Hi,

I haven't checked in for awhile, but just glancing in, saw this

thread. When you turn yellow after eating a lot of vegetables that contain

carotene, it can make you turn yellow, and this is called hypercarotenemia,

but it is not the only way to get this condition. Beta carotene is the

form of vitamin A that has that yellow color. I've put an article about

this condition below that is about someone who couldn't convert beta

carotene to Vitamin A, so that the beta-carotene built up.

What is interesting, though, is it is also possible to make beta-carotene

from vitamin A, but that has happened in unusual circumstances that I think

MIGHT have involved selenium deficiency, which would leave you

hypothyroid. Do you know how well your son's thyroid is doing? Does he

run a low termperature? One of the Defeat Autism Now! doctors who saw

hypercarotenemia in two different patients said both had signs of being

hypothyroid.

Here is a bit of explanantion from a post I wrote the DAN! doctor's list

some years ago, but you can talk to your doctor about this

issue, especially suspect if you have been giving your child a lot of

vitamin A.

From a previous post on this topic:

==================

I've put below a very interesting case study of a patient on parenteral

nutrition that contained NO carotenoids. The longer this patient was on

the diet, the higher the beta-carotene became in the plasma, and

interestingly, in the short term, the retinol went up, but in the long

term, retinol went down while the beta-carotene doubled. This is very

suggestive that there may be a reason for beta-carotene levels to rise when

something unusual is happening biochemically, quite possibly when there is

something important missing from nutrition. A very good suspect is

selenium. Here we tie back to the thyroid issues you mentioned since

selenium is critical to thyroid chemistry. Just to drive this possibility

home, I've put an article below about children on parenteral nutrition who

developed encephalopathy and died of sepsis. On autopsy, they were found

to have NO selenium in the brain. It is interesting to note what else went

wrong with them, so please take the time to read the abstract.

There is pretty good circumstantial evidence that selenium status may need

to be right for the Vitamin A metabolism (or more particularly, something

related to how we process beta-carotene) to work right. This gives us

something else to watch related to using high dose Vitamin A.

You may remember my comment in my presentation at the last DAN! thinktank

that selenium gets low in someone who has been deficient of sulfur for a

long time because the body will grab up the selenium to place in the hands

of the sulfur-managing enzymes in sulfur's stead. That redirection of

selenium, then, slights the selenium-dependent enzymes and other

selenoproteins.

The best measure of selenium status I saw in the literature was testing the

serum level of Selenoprotein P,. I don't know if any of the labs in our

autism community could offer that test, but if a patient is low in

selenium, it severely compromises the immune system which needs selenium

for glutathione peroxidase activity and for thioredoxin reductase. It

makes sense the children in this study died of sepsis.

What about mega-dosing beta-carotene? Does that put strain on the selenium

chemistry? Maybe so. 30 mg/day beta-carotene supplement for 60 days

reduced the level of glutathione peroxidase significantly, although it did

not change the overall selenium content of serum. Losing the enzyme

activity before the serum level is affected may reflect compartmentation

issues related to where beta-carotene uses selenium. I hope you enjoy

reading the abstracts below, where I've also included some articles about

anorexia nervosa and Down Syndrome.

=========================

The occurrence of hypercarotenemia occurring in someone with anorexia may

suggest that limited nutrition could also cause this condition. You might

look at what else is going on in his diet.

I hope this is useful....

Int J Vitam Nutr Res. 1995;65(1):21-3. Related Articles, Links

Hyper-beta-carotenemia unrelated to diet: a case of brain tumor.

Olmedilla B, Granado F, Blanco I.

Nutrition Service, Clinica Puerta de Hierro, Madrid, Spain.

In addition to the provitamin A function of some carotenoids, many of

them exhibit antioxidant activity. Epidemiological studies show that high

serum levels and/or elevated intake of carotenoids have a protector effect

against several chronic and degenerative diseases. We determined the levels

and studied the behavior of the major carotenoids and retinol in serum of a

brain tumor patient receiving standard (carotenoid-free) artificial enteral

nutrition for eight months. After nearly two months on this diet, the

retinol level was in the upper region of normal range and the beta-carotene

concentration was unusually high. Analyses after several months on this

diet showed a decrease in retinol, whereas the beta-carotene concentration

had doubled (up to 203 micrograms/dl). Other carotenoids usually found in

serum were present in very small amounts or not at all. We conclude that,

although diet is an important factor in the presence and proportion of

carotenoids in serum, the case we report here appears to indicate that

other factors related to the development of certain diseases may be

relevant determinants of changes in the carotenoid profile.

Publication Types:

* Case Reports

PMID: 7657475 [PubMed - indexed for MEDLINE]

Acta Neuropathol (Berl). 2003 Sep;106(3):234-42. Epub 2003 Jul 05.

Related Articles, Links

Encephalopathy in megacystis-microcolon-intestinal hypoperistalsis

syndrome patients on long-term total parenteral nutrition possibly due to

selenium deficiency.

Hirato J, Nakazato Y, Koyama H, Yamada A, Suzuki N, Kuroiwa M,

Takahashi A, Matsuyama S, Asayama K.

Department of Pathology, Gunma University School of Medicine, 3-39-22

Showamachi, 371-8511 Maebashi, Japan. jhirato@...

This report concerns two patients (female, 9 and 6 years) who were

diagnosed with megacystis-microcolon-intestinal hypoperistalsis syndrome

(MMIHS). Although they exceeded the usual life expectancy of patients

diagnosed with MMIHS because of total parenteral nutrition (TPN), they

demonstrated progressive neurological deficits and showed histopathological

features in the brain. Both patients were diagnosed with MMIHS in the

neonatal period and were fed by TPN. The first patient developed visual and

gait disturbances at the age of 7 years. Two months later, she developed

dysarthria and muscular weakness, and could not maintain her posture. The

level of serum selenium was extremely low. The second patient developed

flexion and spasticity of the extremities followed by decorticate posture

at the age of 3 years. Both patients died of sepsis. The brain weights of

the two cases were 880 g and 715 g. In both cases, severe neuronal loss and

gliosis were present in the medial convolutions of the occipital lobe,

including the visual cortex. The postcentral gyrus and temporal transverse

gyrus were also involved. In addition, extensive loss of Purkinje cells and

granular neurons, and gliosis were observed in the cerebellum. We measured

the selenium content of the brains and livers using the graphite furnace

atomic absorption spectrometry method. Selenium was not detected in either

brain, although the livers of both cases contained a low level of selenium.

On immunohistochemical examination of the anti-oxidative enzymes,

histiocyte-macrophage lineage cells in MMIHS cases, including microglia and

Kupffer cells, showed only a weak reaction for glutathione peroxidase, of

which selenium is an essential component. However, the cells in the control

cases were strongly positive. In cases of MMIHS and methylmercury

intoxication, the brain features similar lesions, in both their

topographical and histopathological aspects. We considered that the brain

lesions of the MMIHS patients mainly resulted from oxidative damage of the

brain related to the low levels of glutathione peroxidase and other

selenoproteins due to selenium deficiency.

Publication Types:

* Case Reports

PMID: 12845451 [PubMed - indexed for MEDLINE]

Asia Pac J Clin Nutr. 2003;12 Suppl:S14. Related Articles, Links

Selenium and iodine interactions with thyroid status.

Thomson CD.

Department of Human nutrition, University of Otago, Dunedin, New Zealand.

Background - The adequacy of selenium (Se) status may influence iodine

metabolism because of Se's role in the deiodinase enzymes. Se deficiency

may exacerbate symptoms of iodine deficiency. There is little research on

any detrimental effects of marginal selenium intakes on thyroid status.

Objective - This paper reports on two studies investigating (a) the

relationship between Se status and thyroid status in a NZ population and

( the effect of Se supplementation on TSH and the ratio of T(3)/T(4);.

Design - Study 1: Plasma Se was determined in 199 Otago residents for which

data was available on thyroid volume, plasma TSH, and plasma T(4). Study 2:

TSH, T(4) and T(3) were measured in plasma from two supplementation

studies: 57 smokers who received 100 microg Se or a placebo daily as

selenomethionine; 172 subjects who received 200 microg daily as high-Se

yeast (Precise) or a placebo. Outcomes - Study 1: In contrast to

observations in France, preliminary analyses did not show significant

associations between plasma Se and measures of thyroid status. Study2: Se

supplementation resulted in a trend towards lower T(4) confirming an

earlier study of a small but significant fall in T(4). Conclusions - Lack

of association between plasma Se and thyroid status, and non-significant

changes in T(4) suggest that Se status in NZ is adequate for optimal

activity of the deiodinases

PMID: 15023604 [PubMed - in process]

Eur J Biochem. 2002 Nov;269(22):5746-51. Related Articles, Links

[Click here to read]

Characterization of selenoprotein P as a selenium supply protein.

Saito Y, Takahashi K.

Department of Hygienic Chemistry, Graduate School of Pharmaceutical

Sciences, Hokkaido University, Sapporo, Japan.

Selenium (Se) is well known to be essential for cell culture when

using a serum-free medium, but not when a medium containing serum is used.

This finding suggests that serum contains some usable form of Se. To

identify the Se-supplier, T-lymphoma (Jurkat) cells were cultured for 3

days in the presence of human serum immunodepleted of Se-containing serum

protein, selenoprotein P or extracellular glutathione peroxidase. The

Se-dependent enzyme activities (glutathione peroxidases and thioredoxin

reductase) and Se content within the cells markedly decreased only when

cultured with selenoprotein P-depleted serum. Compared with other

Se-containing proteins, the addition of purified selenoprotein P to the

selenoprotein P-depleted serum or a serum-free medium was the most

effective for the recovery of cellular glutathione peroxidase activity

(index of Se status). These results suggest that selenoprotein P functions

as a Se-supply protein, delivering Se to the cells.

PMID: 12423375 [PubMed - indexed for MEDLINE]

1: J Nutr Biochem. 2003 Nov;14(11):656-62. Related Articles, Links

[Click here to read]

Beta-carotene supplementation decreases leukocyte superoxide dismutase

activity and serum glutathione peroxidase concentration in humans.

McGill CR, Green NR, Meadows MC, Gropper SS.

Tropicana Products, Inc., 1001 13th Avenue East, Bradenton, FL 34208,

USA. carla.mcgill@...

The effects of a 30 mg/day beta-carotene supplement for 60 days on

blood cell and serum antioxidant enzymes and selenium concentrations were

examined in healthy adults. Serum beta-carotene concentrations increased

significantly (P < 0.05) in response to supplementation. Forty percent of

subjects exhibited hypercarotenemia of the skin after 30 days. There were

no changes in the activity of red blood cell or leukocyte catalase

activity, red blood cell copper,zinc-dependent superoxide dismutase

activity or serum myeloperoxidase concentration in response to

beta-carotene supplementation. Leukocyte superoxide dismutase activity

decreased significantly (P < 0.05) at 30 and 60 days compared to baseline.

Serum glutathione peroxidase concentration decreased significantly (P <

0.05) between baseline and days 45 and 60 of supplementation. Serum

selenium and blood hemoglobin concentrations did not change during the

study. Supplemental beta-carotene may alter the antioxidant capacity of

plasma and/or blood cells in vivo.

PMID: 14629897 [PubMed - in process]

Int J Eat Disord. 2001 Nov;30(3):299-305. Related Articles, Links

[Click here to read]

Serum beta-carotene in anorexia nervosa patients: a case-control study.

Boland B, Beguin C, Zech F, Desager JP, Lambert M.

Saint-Luc University Hospital, Catholic University of Louvain in

Brussels, Brussels, Belgium.

OBJECTIVE: To study the prevalence of hypercarotenemia in a large

cohort of patients with anorexia nervosa (AN), to compare serum

beta-carotene (betaC) values among restricting and purging AN subjects, and

to investigate whether hypercarotenemia is related to an increase in

low-density lipoprotein (LDL) cholesterol. METHOD: Retrospective

case-control study including 101 female patients and 95 age-matched normal

controls in whom fasting serum betaC and lipid profiles were determined.

RESULTS: The prevalence of hypercarotenemia (>200 microg/dl) in the AN

population was 62%. Mean serum betaC level was significantly higher in AN

patients than in controls (237 +/- 103 vs. 160 +/- 45 microg/dl, p <.0001).

Among AN patients, the level was higher in restricters than in purgers (271

+/- 110 vs. 186 +/- 78 microg/dl, p <.005). Fasting serum total and LDL

cholesterol levels were also significantly higher in patients with AN than

in controls, but no correlation was found between serum betaC and LDL

cholesterol values. DISCUSSION: Hypercarotenemia is a common finding in AN

patients, especially in the restricter subgroup. The high prevalence of

elevated serum betaC in AN patients supports its diagnostic value in

atypical forms of eating disorders. Copyright 2001 by Wiley & Sons, Inc.

PMID: 11746290 [PubMed - indexed for MEDLINE]

J Neurol Neurosurg Psychiatry. 1999 Dec;67(6):829-30. Related Articles, Links

[Click here to read]

White muscle disease in humans: myopathy caused by selenium deficiency

in anorexia nervosa under long term total parenteral nutrition.

Ishihara H, Kanda F, Matsushita T, ChiharaK, Itoh K.

Publication Types:

* Case Reports

* Letter

PMID: 10617385 [PubMed - indexed for MEDLINE]

J Ment Defic Res. 1990 Jun;34 ( Pt 3):283-6. Related Articles, Links

Hypercarotenemia in children with Down's syndrome.

Storm W.

St Vincenz Krankenhaus, Paderborn, F.R.G.

In previous reports, deficiencies in serum vitamin A were considered a

frequent finding in persons with Down's syndrome. Based on this assumption,

the regular determination of both serum carotene and vitamin A has been

recommended for the preventive care of this population. In the author's

preventive medicine clinic for children with Down's syndrome, we have

checked these items routinely in 44 fasting patients (aged 14 months to 19

years). The author was surprised to find no patient with either a

deficiency of carotene or vitamin A, but 14 patients had hypercarotenemia.

Any known aetiology of this finding, such as excessive ingestion, diabetes

mellitus or hypothyroidism, could not be verified. It has to be mentioned

that the previous reports on serum carotene levels were based on

determinations by conventional spectrophotometric methods (normal range:

50-670 micrograms/dl), whereas the author applied an improved method of

high-performance liquid chromatography with a much lower normal range

(50-750 micrograms/l). Further investigations are to be performed to verify

these findings and to evaluate probable mechanisms of hypercarotenemia in

persons with Down's syndrome.

PMID: 2143233 [PubMed - indexed for MEDLINE]

Biol Trace Elem Res. 2000 Winter;78(1-3):35-42. Related Articles, Links

[Click here to read]

Thyroid hypofunction in Down's syndrome: is it related to oxidative

stress?

Kanavin OJ, Aaseth J, Birketvedt GS.

Department of Pediatry, Buskerud Central Hospital, Drammen, Norway.

Oxidative stress affecting the thyroxin biosynthesis might explain the

proneness of patients with Down's syndrome (DS) (trisomia 21) to develop

hypothyroidism. Thyroideal cells are exposed to endogenous H2O2 that acts

as a cofactor for the iodination of thyroxin precursors. The gland has high

levels of selenium-containing proteins, including peroxide-detoxicating

enzyme proteins. The object of the present study was to explore the

hypothesis of a role of an imbalance between toxic oxygen production and

protective metalloenzymes during the development of thyroid hypofunction in

DS patients. We analyzed serum levels of thyroid hormones and trace metals

in 38 institutionalized adults with DS, using mentally retarded subjects

matched for age, sex, and behavioral function as controls. The DS patients

had significantly lower mean values of free thyroxin (fT4) and increased

TSH (thyroid stimulating hormone), as compared to the controls. They had

lower serum selenium than the controls. A positive correlation was observed

between serum concentrations of fT4 and selenium in the DS patients (r =

0.393, p < 0.05). No significant differences were found between the fT4 or

the TSH concentrations in the patients with and without circulating

antithyroid autoantibodies. Our results support the suggestion that thyroid

hypofunction in patients with Down's syndrome in some way is linked to the

low serum levels of selenium found in these patients. It is suggested that

selenium-containing proteins are involved in thyroid hormonal synthesis, by

protecting biosynthetic processes against the toxicity of free oxygen radicals.

PMID: 11314986 [PubMed - indexed for MEDLINE]

===================

http://archopht.ama-assn.org/cgi/content/full/121/9/1326.

J Pak Med Assoc. 1976 Nov;26(11):224-5.Links

Hypercarotenemia-a case report.

<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Ibrahim%2\

0K%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_\

RVAbstractPlusDrugs1>Ibrahim

K,

<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Kara%20RY\

%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RV\

AbstractPlusDrugs1>Kara

RY,

<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22Zuberi%20\

SJ%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_\

RVAbstractPlusDrugs1>Zuberi

SJ.

A case report of hypercarotenemia is presented here. Hypercarotenemia was

purely due to an excessive intake of carotene rich foods. The patient being

a diabetic could not convert dietary carotene to vitamin A.

PMID: 829149 [PubMed - indexed for MEDLINE]

Have you been giving beta carotene or vitamin A as a supplement? The

article above talked about a failure to convert beta carotene to vitamin A

but sometimes there is an unusual conversion of vitamin A to beta carotene,

so people develop hypercarotenemia even if they aren't eating a lot of high

carotene foods or taking beta carotene as a supplement.

At 12:23 AM 12/1/2007, you wrote:

>I am SO relieved - thank you for posting despite how busy this

>disease keeps us all. Babies are often yellow when they are born and

>the remedy is to put them in sunlight...I do not think it is their

>livers...so perhaps they turn this color for the same reason as your

>son...and sunlight ( vitamin D? ) is the cure for jaundiced babies as

>far as I know....LOL Di

> > > >

> > > > Hello everyone,

> > > >

> > > > My son's feet have been a noticeable golden yellow for some

>time.

> > > His hands as well but not as bad. Then suddenly, his whole body

>went

> > > yellow. I mean REALLY yellow. So we rushed him for some blood

>tests

> > > to check his liver and kidneys and everything was just fine,

> > including

> > > bilirubin. Our doctor couldn't figure it out either. Then he went

> > > back to normal for about two weeks, except for his feet. Then it

> > > happened again. He went orange for one day and then practically

> > > glow-in-the-dark yellow again for about 5 days. Then back to

>normal.

> > > Both times he seemed exhausted and whiny.

> > > >

> > > > Anybody experience this? Any ideas as to what's happening to

>him?

> > > >

> > > > Thanks in advance,

> > > >

> > > > Stéphanie B.

> > > >

> > > >

> > > > ---------------------------------

> > > > Be a better sports nut! Let your teams follow you with Yahoo

> > Mobile.

> > > Try it now.

> > > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > > ---------------------------------

> > > Be a better sports nut! Let your teams follow you with Yahoo

> > Mobile. Try it now.

> > >

> >

> >

> >

> >

> >

> >

> > ---------------------------------

> > Be a better sports nut! Let your teams follow you with Yahoo

>Mobile. Try it now.

> >

>

>

--

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PM

[Guest guest]

When my son was about 9 or 10 yrs. old his feet, hands, and neck

turned a yellow, orangish color. My daughter said he looked like

a duck. The doctors said it was from eating too many yellow

vegetables, but at that time he ate very few vegetables especially

yellow ones. Eventually it went away, but last year he was

diagnosed with hypothyroidism - low T3.

>

> Hi,

>

> I haven't checked in for awhile, but just glancing in, saw this

> thread. When you turn yellow after eating a lot of vegetables that

contain

> carotene, it can make you turn yellow, and this is called

hypercarotenemia,

> but it is not the only way to get this condition. Beta carotene is

the

> form of vitamin A that has that yellow color. I've put an article

about

> this condition below that is about someone who couldn't convert

beta

> carotene to Vitamin A, so that the beta-carotene built up.

>

> What is interesting, though, is it is also possible to make beta-

carotene

> from vitamin A, but that has happened in unusual circumstances that

I think

> MIGHT have involved selenium deficiency, which would leave you

> hypothyroid. Do you know how well your son's thyroid is doing?

Does he

> run a low termperature? One of the Defeat Autism Now! doctors who

saw

> hypercarotenemia in two different patients said both had signs of

being

> hypothyroid.

>