RESEARCH - Clinical manifestations and antiphosphatidylserine antibodies in patients with SLE: is there an association?

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Clin Rheumatol. 2007 Feb;26(2):154-60. Epub 2006 Apr 6.

Clinical manifestations and antiphosphatidylserine antibodies in patients

with systemic lupus erythematosus: is there an association?

Division of Rheumatology, Department of Internal Medicine, Faculty of

Medicine, Suleyman Demirel University, Isparta, Turkey.

Objective: Antiphospholipid antibodies are a group of heterogeneous

autoantibodies which have been reported in systemic lupus erythematosus

(SLE) and antiphospholipid syndrome (APS) in association with thrombosis,

fetal loss, and thrombocytopenia. In this study, we aimed to reveal the

prevalence and correlation of IgG, IgA, and IgM isotypes of antibodies to

cardiolipin (aCL) and antiphosphatidylserine (aPS) with clinical and

laboratory manifestations of SLE patients. Methods: Fifty-nine SLE patients

and 41 healthy controls were included. Fifteen of patients (25.4%) had

secondary APS. aCL and aPS antibody assays were performed by enzyme-linked

immunosorbent assay. Results: All isotypes of aCL and aPS antibodies except

IgG were higher in patients with or without APS than those in the healthy

controls (p<0.001). The most significant associations were found among

migraine and IgA aCL (p<0.001), livedo reticularis and both IgM aCL and IgM

aPS (p<0.001), migraine and IgM aCL (p<0.01), pulmonary involvement and IgM

aCL (p<0.01), migraine and IgA aPS (p<0.01), and both thrombosis and

migraine with IgM aPS (p<0.01). Conclusion: A relatively high prevalence of

aCL and aPS antibodies was found in our SLE patients. It seems that isotypes

of IgM aCL, IgM aPS, IgA aCL, and IgA aPS antibodies are correlated well

with migraine and IgM aPS with thrombosis in SLE patients with secondary

APS. The assessment of both IgM and IgA isotypes of aPS and aCL antibodies

may be helpful in predicting these manifestations.

PMID: 16598413

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstra\

ctPlus & list_uids=16598413

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