Kineret vs. Enbrel (Orencia, Humira and Remicade)

[Guest guest]

Kineret is an Interleukin blocker. This link is sort of technical but does

compare the IL's and TNF's

http://www.hopkins-arthritis.som.jhmi.edu/news-archive/2003/il1trap.html

You can find information on Kineret at www.kineretrx.com

Enbrel, Remicade and Humira and Orencia are TNF blockers. See link below for

details about TNF's. http://www.midwestarthritis.com/Pages/TNF%20blockers.html

Orencia® (abatacept), the first selective modulator of a co-stimulatory signal

required for full T-cell activation, for the treatment of rheumatoid arthritis

(RA). For more on ORENCIA, check these links. NOTE: Orencia is NOT reccommended

to be used with TNF blockers.

http://www.bms.com/news/press/data/fg_press_release_6097.html

http://www.orencia.com/orencia/splash/content/content.jsp?BV_UseBVCookie=Yes & con\

tentId=News_About_Orencia

http://www.orencia.com/Splash/Includes/ORENCIA_PPI.pdf

Recent studies and clinical trials have shown that a lot of patients with

Stills do seem to respond better to Kineret but there is no conclusive proof so

far or at least none published in any current works that I could find. I just

remember hearing this from my Rheumatologist and reading it somewhere. On the

other hand, many do well on the TNF's as well. Some can't tolerate Kineret at

all. If you fail one TNF, you still should try the others as they all work in

slightly different ways.

There is also research being conducted that will " test " a person to see which

BRM will work best for him / her but that reality is most likely a long ways off

in the future. Best bet is to talk to your doctor and see what he thinks is best

for you, given your particular circumstances and case of Stills. This disease is

very individual in some ways.

Best wishes for a wise drug choice that will work the first time. I tried

Humira with some results but very slow in the coming. I took it for 8 months. I

was switched to Kineret and felt immediate results, like in 5 minutes or so

after I injected. I've been taking Kineret for almost 2 years now. It keeps me

on my feet .... as good as I get anyway.

Cost: They are all about the same for a months supply... in the $1200 -

1500.00 price range per month. If you don't have insurance and need one of

these drugs, most of the manufacturers will donate it for you with a doctor's

note that it is medically necessary for you.

Dosing: Kineret = daily pre filled glass syringes home injected by patient.

Enbrel = twice a week, reconstituted mixing, patient home injects

Humira = every week or two, prefilled, " arthritis assist " (has attached

" handles " for ease of injections by arthritic hands) injectable for home use

Remicade = every 4 - 8 weeks infusion at doctors office, hospital or clinic

Orencia = reconstituted medication given by IV similar to Remicade and doses

are similar schedule.

Hope this helps clear up some of the questions you may have had.

Smiles, Caroline the First

Empress of CUS

(Beautiful Southern Oregon, USA)

We may not be able to change the direction of the wind, but we can adjust our

sails.

May you have enough happiness to make you kind, enough trials to make you

strong, enough sorrow to keep you human, enough hope to make you happy.

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[Guest guest]

Caroline,

Thanks for all the great info on what has become a big discussion this week

online.

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[Guest guest]

Hey Caroline,

Update--the new Enbrel can be done in one weekly injection (I think

it's 50 mg) and doesn't need mixing.

in Maine

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> Enbrel = twice a week, reconstituted mixing, patient home injects

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