Re: Fine particles and thrombosis

[Guest guest]

Steve:

Cardiovascular effects, etc., is NOT my area of expertise, but I am aware of chrystobilite fibers being detected in the blood stream (of workers at a aggregate quarry) and the only plausible explanation seemed to point to fiber migration from lung tissue. Yes, pretty serious stuff!

--

Geyer, PE, CIH, CSP

President

KENTEC Industries, Inc.

Bakersfield, California

www.kerntecindustries.com

Are these two phenomena related? Pretty serious stuff.

Steve Temes

Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects.

Nemmar A <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Search & itool=PubMed_Abstract & term=%22Nemmar+A%22%5BAuthor%5D> , Hoylaerts MF <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Search & itool=PubMed_Abstract & term=%22Hoylaerts+MF%22%5BAuthor%5D> , Hoet PH <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Search & itool=PubMed_Abstract & term=%22Hoet+PH%22%5BAuthor%5D> , Nemery B <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Search & itool=PubMed_Abstract & term=%22Nemery+B%22%5BAuthor%5D> .

Laboratory of Pneumology, Unit of Lung Toxicology, K.U. Leuven, Herestraat, 49, Leuven 3000, Belgium. abderrahim.nemmar@...

Particulate air pollution is associated with cardiovascular morbidity and mortality. Fine particles with a diameter <2.5 microm (PM2.5) have an important role in triggering biological responses. These particles, and particularly the ultrafine fraction (<100 nm) penetrate deeply into the respiratory tract. Recently, we have demonstrated that ultrafine particles are able to translocate from the lung into the systemic circulation in hamsters and humans. In urban areas, diesel engines are considered to be the major source of PM2.5. We therefore evaluated the acute effect (1 h) of diesel exhaust particles (DEP) in a hamster model of peripheral vascular thrombosis induced by free-radical mediated endothelial injury, using intravenous Rose Bengal and local illumination. Intratracheal doses of 5-500 microg of DEP per animal induced inflammation with elevation of neutrophils, total proteins and histamine in bronchoalveolar lavage. DEP enhanced experimental arterial and venous platelet rich-thrombus formation in vivo. Blood samples taken from hamsters 30 and 60 min after instillation of DEP caused platelet activation, when analyzed in the Platelet Function Analyser (PFA-100). The direct addition of DEP to untreated hamster blood also caused platelet aggregation. These effects persisted up to 24 h after instillation. Our results provide plausible mechanistic explanations for the epidemiologically established link between air pollution and acute cardiovascular effects.

PMID: 15093270 [PubMed - indexed for MEDLINE]

Did you know that complications from DVT blood clots kill up to 200,000 people in the U.S. each year?

Deep Vein Thrombosis, or DVT <http://www.dvt.net/dvtDefined.do?id=11> , is a blood clot that can form in your legs and sometimes move to your lungs, where it could be fatal. In fact, complications from DVT blood clots contribute to more deaths each year than AIDS and breast cancer combined. And cancer and certain heart or respiratory diseases increase the risk.

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