Clomid study for Hypogonadism

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I am posting this for informational purposes. Hopefully it will help

others with this condition. Many folks on the list have had blood work

done.

The general definition of hypogonadism is 300ng/dl, but age is also a

consideration (it should be). If your 20 or 30 y.o., you should have a

T level of about 800ng/dl. Here is the treatment study I found.

Maybe it would be a good idea to print this study so your doctor won't

be a total dumb @ss..

Clomid study, notice the dose used just 25mg/day:

Clomiphene Citrate Effects on Testosterone/Estrogen Ratio in Male

Hypogonadism

J Sex Med 2005;2:716–721.

ABSTRACT

Aim. Symptomatic late-onset hypogonadism is associated not only with a

decline in serum testosterone, but also with a rise in serum

estradiol. These endocrine changes negatively affect libido, sexual

function, mood, behavior, lean body mass, and bone density. Currently,

the most common treatment is exogenous testostosterone therapy. This

treatment can be associated with skin irritation, gynecomastia, nipple

tenderness, testicular atrophy, and decline in sperm counts. In this

study we investigated the efficacy of clomiphene citrate in the

treatment of hypogonadism with the objectives of raising endogenous

serum testosterone (T) and improving the testosterone/estrogen (T/E)

ratio.

Methods. Our cohort consisted of 36 Caucasian men with hypogonadism

defined as serum testosterone level less than 300 ng/dL. Each patient

was treated with a daily dose of 25 mg clomiphene citrate and followed

prospectively. Analysis of baseline and follow-up serum levels of

testosterone and estradiol levels were performed.

Results. The mean age was 39 years, and the mean pretreatment

testosterone and estrogen levels were 247.6 ± 39.8 ng/dL and 32.3 ±

10.9, respectively. By the first follow-up visit (4–6 weeks),

the mean testosterone level rose to 610.0 ± 178.6 ng/dL (P < 0.00001).

Moreover, the T/E ratio improved from 8.7 to 14.2 (P < 0.001). There

were no side effects reported by the patients.

Conclusions. Low dose clomiphene citrate is effective in elevating

serum testosterone levels and improving the testosterone/estadiol

ratio in men with hypogonadism. This therapy represents an alternative

to testosterone therapy by stimulating the endogenous androgen

production pathway.

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