Jump to content
RemedySpot.com

Re: almost healed with tianeptine (stablon)

Rate this topic


Guest guest

Recommended Posts

How long were you on risperdal for and what was the

exact dose you were on...Also this is good news i read

about the drug just now overlooking it before... it

seems to do the exact opposite of risperdal...It

regulates the HPA and fixes glutamate which risperdal

f*ks up completely...also changes the serotonin which

could be good or bad for just pssd

sufferers...Hopefully you continue to improve i'm

looking forward to hearing more from you...Also did

your doc prescribe this off-label b/c it says not

prescribed in the US....how did you get it unless you

aren't in the states....

all the best nuretronics!!!

What I like best from here

http://www.tianeptine.com/

" Sustained use of tianeptine tends to " normalise " the

hypothalamic-pituitary-adrenal (HPA) system. "

" Prolonged tianeptine use also reduces some forms of

stress-induced apoptosis ( " programmed cell-death " ),

notably in the temporal cortex and dentate gyrus of

the hippocampus. At the molecular level, tianeptine

exerts profound effects on the glutamate system. The

amino acid glutamate serves as the main excitatory

neurotransmitter in the brain. Its excitatory action

is mediated by via multiple receptor subtypes. The

three main subtypes of glutamate-gated ion channel are

kainate, ampa, and N-methyl-D-aspartate (NMDA).

Tianeptine prevents overstimulation of AMPA/kainate

type glutamate receptors in the hippocampus that

regulate Ca2+ entry into the nerve cell; excess Ca2+

entry into nerve cells is toxic. Tianeptine also

modulates the NMDA glutamate receptors. NMDA receptors

for glutamate play a critical role in mediating the

functional and intracellular effects of stress "

--- jonny_man19 wrote:

>

> Dear all,

>

> I started tianeptine on 2nd of january, and

> my health improved gradually over 4 weeks. Now

> I feel almost biologically healed:

> -Normal emotions (before I had no emotions at all)

> -Normal good skin sensitivity (before i was afraid

> to be touched).

> -Gained command again over my body (can do some

> jogging again,

> before I was not able do do and enjoy any

> effort). Before my

> body felt that bad that i thought it was not mine

> anymore and

> my doctor thought that I had schizophrenia

> -I have much less depersonalization, but I still

> feel a bit strange

> -I read again newspapers, books

> -I have no more problems to control my

> urine(before I had a little

> bit problems)

> -can have some nice sex again, and getting an

> orgasm is nice again.

> -have some libido (girls are more erotic than

> trees again)

> -I can sleep again (before I sometimes slept only

> 2hours and

> when taking Risperdal I slept very much)

> -I am not that anxious anymore (no more free

> floating fear)

> -my apetite is normal again

>

> I hope my health will not deteriorate again

>

> I don't know whether I had PSSD, a clinical

> depression or

> schizophrenia, or some mixture of all these

> illnesses, but my

> Illness started one week after I took seroxat (a

> ssri), almost

> two years ago

> I don't even know if most of the people here have

> the same

> illness or if everyone is a different case, as I am

> one of

> the only ones who improved with tianeptine.

>

> Maybe psychology and god played also a big part in

> the improvement,

> first my trust in god improved, then faith in myself

> came back,

> then I did more resarch on the internet, and thought

> that

> tianeptine fitted my symptoms best, and I calculated

> (sorry I was

> a mathematician) that the probability that I had no

> schizophrenia

> but that it was more clinical depression was one in

> five (probability

> my doctor was wrong), and that tianeptine could cure

> that depression

> given that i had a depression was one in five too,

> so the probability

> to get " healed " by tianeptine was on in 25, thus I

> was quite lucky.

> I was also lucky my doctor was very nice and said

> that i could try

> tianeptine

> Regards and thanks for all your support and help

>

> Jean

>

>

>

> This group is for support, discussion, or

> educational purposes only. It does not provide

> psychiatric or medical care. All medications and

> supplements should be taken under a doctor's

> supervision.

>

Link to comment
Share on other sites

Good story. Being an SSRI antagonist, tianeptine might theoretically

be a cure for PSSD IMHO. It may cause its own side effects though.

More people tried this stuff?

>

>

> Dear all,

>

> I started tianeptine on 2nd of january, and

> my health improved gradually over 4 weeks. Now

> I feel almost biologically healed:

> -Normal emotions (before I had no emotions at all)

> -Normal good skin sensitivity (before i was afraid to be touched).

> -Gained command again over my body (can do some jogging again,

> before I was not able do do and enjoy any effort). Before my

> body felt that bad that i thought it was not mine anymore and

> my doctor thought that I had schizophrenia

> -I have much less depersonalization, but I still feel a bit strange

> -I read again newspapers, books

> -I have no more problems to control my urine(before I had a little

> bit problems)

> -can have some nice sex again, and getting an orgasm is nice again.

> -have some libido (girls are more erotic than trees again)

> -I can sleep again (before I sometimes slept only 2hours and

> when taking Risperdal I slept very much)

> -I am not that anxious anymore (no more free floating fear)

> -my apetite is normal again

>

> I hope my health will not deteriorate again

>

> I don't know whether I had PSSD, a clinical depression or

> schizophrenia, or some mixture of all these illnesses, but my

> Illness started one week after I took seroxat (a ssri), almost

> two years ago

> I don't even know if most of the people here have the same

> illness or if everyone is a different case, as I am one of

> the only ones who improved with tianeptine.

>

> Maybe psychology and god played also a big part in the improvement,

> first my trust in god improved, then faith in myself came back,

> then I did more resarch on the internet, and thought that

> tianeptine fitted my symptoms best, and I calculated (sorry I was

> a mathematician) that the probability that I had no schizophrenia

> but that it was more clinical depression was one in five (probability

> my doctor was wrong), and that tianeptine could cure that depression

> given that i had a depression was one in five too, so the probability

> to get " healed " by tianeptine was on in 25, thus I was quite lucky.

> I was also lucky my doctor was very nice and said that i could try

> tianeptine

> Regards and thanks for all your support and help

>

> Jean

>

Link to comment
Share on other sites

uptake of serotonin would increase neural nitric oxide synthesis in

the brain.

>

> >

> > Dear all,

> >

> > I started tianeptine on 2nd of january, and

> > my health improved gradually over 4 weeks. Now

> > I feel almost biologically healed:

> > -Normal emotions (before I had no emotions at all)

> > -Normal good skin sensitivity (before i was afraid

> > to be touched).

> > -Gained command again over my body (can do some

> > jogging again,

> > before I was not able do do and enjoy any

> > effort). Before my

> > body felt that bad that i thought it was not mine

> > anymore and

> > my doctor thought that I had schizophrenia

> > -I have much less depersonalization, but I still

> > feel a bit strange

> > -I read again newspapers, books

> > -I have no more problems to control my

> > urine(before I had a little

> > bit problems)

> > -can have some nice sex again, and getting an

> > orgasm is nice again.

> > -have some libido (girls are more erotic than

> > trees again)

> > -I can sleep again (before I sometimes slept only

> > 2hours and

> > when taking Risperdal I slept very much)

> > -I am not that anxious anymore (no more free

> > floating fear)

> > -my apetite is normal again

> >

> > I hope my health will not deteriorate again

> >

> > I don't know whether I had PSSD, a clinical

> > depression or

> > schizophrenia, or some mixture of all these

> > illnesses, but my

> > Illness started one week after I took seroxat (a

> > ssri), almost

> > two years ago

> > I don't even know if most of the people here have

> > the same

> > illness or if everyone is a different case, as I am

> > one of

> > the only ones who improved with tianeptine.

> >

> > Maybe psychology and god played also a big part in

> > the improvement,

> > first my trust in god improved, then faith in myself

> > came back,

> > then I did more resarch on the internet, and thought

> > that

> > tianeptine fitted my symptoms best, and I calculated

> > (sorry I was

> > a mathematician) that the probability that I had no

> > schizophrenia

> > but that it was more clinical depression was one in

> > five (probability

> > my doctor was wrong), and that tianeptine could cure

> > that depression

> > given that i had a depression was one in five too,

> > so the probability

> > to get " healed " by tianeptine was on in 25, thus I

> > was quite lucky.

> > I was also lucky my doctor was very nice and said

> > that i could try

> > tianeptine

> > Regards and thanks for all your support and help

> >

> > Jean

> >

> >

> >

> > This group is for support, discussion, or

> > educational purposes only. It does not provide

> > psychiatric or medical care. All medications and

> > supplements should be taken under a doctor's

> > supervision.

> >

Link to comment
Share on other sites

it compounds my theory that the ssris have actually depleted

presynaptic serotonin and this is the problem.

> >

> >

> > Dear all,

> >

> > I started tianeptine on 2nd of january, and

> > my health improved gradually over 4 weeks. Now

> > I feel almost biologically healed:

> > -Normal emotions (before I had no emotions at all)

> > -Normal good skin sensitivity (before i was afraid to be

touched).

> > -Gained command again over my body (can do some jogging again,

> > before I was not able do do and enjoy any effort). Before my

> > body felt that bad that i thought it was not mine anymore and

> > my doctor thought that I had schizophrenia

> > -I have much less depersonalization, but I still feel a bit

strange

> > -I read again newspapers, books

> > -I have no more problems to control my urine(before I had a

little

> > bit problems)

> > -can have some nice sex again, and getting an orgasm is nice

again.

> > -have some libido (girls are more erotic than trees again)

> > -I can sleep again (before I sometimes slept only 2hours and

> > when taking Risperdal I slept very much)

> > -I am not that anxious anymore (no more free floating fear)

> > -my apetite is normal again

> >

> > I hope my health will not deteriorate again

> >

> > I don't know whether I had PSSD, a clinical depression or

> > schizophrenia, or some mixture of all these illnesses, but my

> > Illness started one week after I took seroxat (a ssri), almost

> > two years ago

> > I don't even know if most of the people here have the same

> > illness or if everyone is a different case, as I am one of

> > the only ones who improved with tianeptine.

> >

> > Maybe psychology and god played also a big part in the

improvement,

> > first my trust in god improved, then faith in myself came back,

> > then I did more resarch on the internet, and thought that

> > tianeptine fitted my symptoms best, and I calculated (sorry I was

> > a mathematician) that the probability that I had no schizophrenia

> > but that it was more clinical depression was one in five

(probability

> > my doctor was wrong), and that tianeptine could cure that

depression

> > given that i had a depression was one in five too, so the

probability

> > to get " healed " by tianeptine was on in 25, thus I was quite

lucky.

> > I was also lucky my doctor was very nice and said that i could try

> > tianeptine

> > Regards and thanks for all your support and help

> >

> > Jean

> >

>

Link to comment
Share on other sites

rite, all my research so far points towards ssris depleting serotonin

from neurons, while you were on ssris the uptake of serotonin into

the neurons was inhibited.

you released serotonin into synapsis when you had a thought or

experienced an emotion, this serotonin was prevented form re-entering

the neurons that it came from. mao destroyed the serotonin that the

ssri's prevented from re-entering the neurons. thus creating a

depletion of serotonin in the actual neuron its self for future use.

when serotonin is released from a neuron in a normal processes (with

out ssri) 10% is broken down by mao, the remaining 90% is what should

have been recycled back into the neuron through the serotonin

transporter (sert) that the ssri has blocked. its reasonable to

assume the 10%lost during normal functioning is replaced through

dietary consumption of tryptophan, this 10% at most is what the

ssri's left us with after we discontinued the treatment. (this is not

enough)(would it be fair to say ssris left us with 10% or less

sexuality?)

also its the re-uptake of serotonin into the neuron that synthesizes

neural nitric oxide (this is prevented by the ssri) and we are left

with so little presynaptic serotonin that reuptake of that small

ammount isnt enough to stimulate enough neural nitric oxide, when you

get an erection its neuronal nitric oxide that is released from the

nerves in the penis that then triggers a rush of blood into the penis

that then triggers more nitric oxide to be released from endothelial

cells in the penis. that first neural nitric oxide signal came from

the brain, so its likely that uptake of serotonin had something to do

with this signal, (the ssri disrupted this because it prevents uptake

of serotonin.)

its unclear to me what would happen to a neuron that is depleted of a

neurotransmitter, but i suppose its reasonable to assume it takes on

a smaller structure and possibly grows new connections in an attempt

to compensate.(neuroplasticity)

if its not clear to any of you what im on about with all this, here

it is in simplest terms. the ssri took serotonin out of your brain

and was the instigator of its destruction. this drug puts it back.

another thing thats good about this drug is its half life is only 2.5

hours so it would be easy to start low and build up then ween off.

http://en.wikipedia.org/wiki/Tianeptine

http://www.servier.com/pro/Neurosciences/stablon/stablon_press.asp

http://www.servier.com/pro/Neurosciences/stablon/stablon_video.asp

Link to comment
Share on other sites

Couple questions.

1) What is an appropriate daily dosage?

2) How can one get a hold of this since it is not available in the US?

Are sites like this one legal or reputable?

http://www.your-onlinepharmacy.com/dr/n/Tianeptine.shtml

Seems shady to me. But even if my doctor was cool with it, I don't

know how or where I'd get it that would be any different.

3) Does anyone know if this would be relevant to the sort of PSSD that

includes low testosterone levels? Did the first poster have low

testosterone levels? Any theories?

>

> rite, all my research so far points towa

rds ssris depleting serotonin

> from neurons, while you were on ssris the uptake of serotonin into

> the neurons was inhibited.

>

> you released serotonin into synapsis when you had a thought or

> experienced an emotion, this serotonin was prevented form re-entering

> the neurons that it came from. mao destroyed the serotonin that the

> ssri's prevented from re-entering the neurons. thus creating a

> depletion of serotonin in the actual neuron its self for future use.

>

> when serotonin is released from a neuron in a normal processes (with

> out ssri) 10% is broken down by mao, the remaining 90% is what should

> have been recycled back into the neuron through the serotonin

> transporter (sert) that the ssri has blocked. its reasonable to

> assume the 10%lost during normal functioning is replaced through

> dietary consumption of tryptophan, this 10% at most is what the

> ssri's left us with after we discontinued the treatment. (this is not

> enough)(would it be fair to say ssris left us with 10% or less

> sexuality?)

>

> also its the re-uptake of serotonin into the neuron that synthesizes

> neural nitric oxide (this is prevented by the ssri) and we are left

> with so little presynaptic serotonin that reuptake of that small

> ammount isnt enough to stimulate enough neural nitric oxide, when you

> get an erection its neuronal nitric oxide that is released from the

> nerves in the penis that then triggers a rush of blood into the penis

> that then triggers more nitric oxide to be released from endothelial

> cells in the penis. that first neural nitric oxide signal came from

> the brain, so its likely that uptake of serotonin had something to do

> with this signal, (the ssri disrupted this because it prevents uptake

> of serotonin.)

>

>

> its unclear to me what would happen to a neuron that is depleted of a

> neurotransmitter, but i suppose its reasonable to assume it takes on

> a smaller structure and possibly grows new connections in an attempt

> to compensate.(neuroplasticity)

>

> if its not clear to any of you what im on about with all this, here

> it is in simplest terms. the ssri took serotonin out of your brain

> and was the instigator of its destruction. this drug puts it back.

>

> another thing thats good about this drug is its half life is only 2.5

> hours so it would be easy to start low and build up then ween off.

>

>

> http://en.wikipedia.org/wiki/Tianeptine

>

> http://www.servier.com/pro/Neurosciences/stablon/stablon_press.asp

>

> http://www.servier.com/pro/Neurosciences/stablon/stablon_video.asp

>

Link to comment
Share on other sites

I'm very intrigued:

Are there any similar drugs that are easier to get a hold of in the USA?

The recent posts on Tianeptine particularly intrigue me because my

anxiety has lowered along with my blunted emotional and sexual

feeling, and increased anxiety is one of the possible side effects of

this drug which basically does the opposite of an SSRI. Hmm...

I'm very interested in any theory of how this drug might or might not

effect my testosterone level (keeping in mind that I am currently

below normal range).

www.Tianeptine.com offers some VERY interesting suggestions:

" Current evidence suggests that tianeptine acts to prevent and even

reverse stress-induced neural damage, promoting both neuronal survival

and synaptic plasticity. Sustained use of tianeptine tends to

" normalise " the hypothalamic-pituitary-adrenal (HPA) system. "

" The side-effect profile of tianeptine is unusually benign. "

" Since melancholic depression is strongly associated with

hypercortisolaemia, which tianeptine reverses, tianeptine may in fact

offer comparable long-term protection against relapse and recurrence. "

" Unlike SSRIs and other " serotonergic " antidepressants, tianeptine

does not dampen libido or sexual performance. Indeed sexual function

may even be enhanced. "

This seems very promising indeed.

Unfortunately, it also costs a freaking fortune and no help from

insurance is in sight...

How'd you pay for it? Do you plan on staying on it indefinitely?

Please let us know what happens if you discontinue treatment.

~

>

>

> Dear all,

>

> I started tianeptine on 2nd of january, and

> my health improved gradually over 4 weeks. Now

> I feel almost biologically healed:

> -Normal emotions (before I had no emotions at all)

> -Normal good skin sensitivity (before i was afraid to be touched).

> -Gained command again over my body (can do some jogging again,

> before I was not able do do and enjoy any effort). Before my

> body felt that bad that i thought it was not mine anymore and

> my doctor thought that I had schizophrenia

> -I have much less depersonalization, but I still feel a bit strange

> -I read again newspapers, books

> -I have no more problems to control my urine(before I had a little

> bit problems)

> -can have some nice sex again, and getting an orgasm is nice again.

> -have some libido (girls are more erotic than trees again)

> -I can sleep again (before I sometimes slept only 2hours and

> when taking Risperdal I slept very much)

> -I am not that anxious anymore (no more free floating fear)

> -my apetite is normal again

>

> I hope my health will not deteriorate again

>

> I don't know whether I had PSSD, a clinical depression or

> schizophrenia, or some mixture of all these illnesses, but my

> Illness started one week after I took seroxat (a ssri), almost

> two years ago

> I don't even know if most of the people here have the same

> illness or if everyone is a different case, as I am one of

> the only ones who improved with tianeptine.

>

> Maybe psychology and god played also a big part in the improvement,

> first my trust in god improved, then faith in myself came back,

> then I did more resarch on the internet, and thought that

> tianeptine fitted my symptoms best, and I calculated (sorry I was

> a mathematician) that the probability that I had no schizophrenia

> but that it was more clinical depression was one in five (probability

> my doctor was wrong), and that tianeptine could cure that depression

> given that i had a depression was one in five too, so the probability

> to get " healed " by tianeptine was on in 25, thus I was quite lucky.

> I was also lucky my doctor was very nice and said that i could try

> tianeptine

> Regards and thanks for all your support and help

>

> Jean

>

Link to comment
Share on other sites

nemo.shark, this kind of post should be in a diferent thread.

This theory doesn't even apply to this guys case because he was on

risperdal for 16 months and that would have caused more sexual

dysfunction than the SSRI.

>

> rite, all my research so far points towards ssris depleting serotonin

> from neurons, while you were on ssris the uptake of serotonin into

> the neurons was inhibited.

>

> you released serotonin into synapsis when you had a thought or

> experienced an emotion, this serotonin was prevented form re-entering

> the neurons that it came from. mao destroyed the serotonin that the

> ssri's prevented from re-entering the neurons. thus creating a

> depletion of serotonin in the actual neuron its self for future use.

>

> when serotonin is released from a neuron in a normal processes (with

> out ssri) 10% is broken down by mao, the remaining 90% is what should

> have been recycled back into the neuron through the serotonin

> transporter (sert) that the ssri has blocked. its reasonable to

> assume the 10%lost during normal functioning is replaced through

> dietary consumption of tryptophan, this 10% at most is what the

> ssri's left us with after we discontinued the treatment. (this is not

> enough)(would it be fair to say ssris left us with 10% or less

> sexuality?)

>

> also its the re-uptake of serotonin into the neuron that synthesizes

> neural nitric oxide (this is prevented by the ssri) and we are left

> with so little presynaptic serotonin that reuptake of that small

> ammount isnt enough to stimulate enough neural nitric oxide, when you

> get an erection its neuronal nitric oxide that is released from the

> nerves in the penis that then triggers a rush of blood into the penis

> that then triggers more nitric oxide to be released from endothelial

> cells in the penis. that first neural nitric oxide signal came from

> the brain, so its likely that uptake of serotonin had something to do

> with this signal, (the ssri disrupted this because it prevents uptake

> of serotonin.)

>

>

> its unclear to me what would happen to a neuron that is depleted of a

> neurotransmitter, but i suppose its reasonable to assume it takes on

> a smaller structure and possibly grows new connections in an attempt

> to compensate.(neuroplasticity)

>

> if its not clear to any of you what im on about with all this, here

> it is in simplest terms. the ssri took serotonin out of your brain

> and was the instigator of its destruction. this drug puts it back.

>

> another thing thats good about this drug is its half life is only 2.5

> hours so it would be easy to start low and build up then ween off.

>

>

> http://en.wikipedia.org/wiki/Tianeptine

>

> http://www.servier.com/pro/Neurosciences/stablon/stablon_press.asp

>

> http://www.servier.com/pro/Neurosciences/stablon/stablon_video.asp

>

Link to comment
Share on other sites

my dose of tianeptine is 2 pills a day (1 pill is 12.5mg)but the recommended dose is 3 pills a dayI live in europe, so I had no problems to get the pills.Even if tianeptine worked for me it might not work for you, but there might be another solution for you, do not give up hope.Even if tianeptine heals you biologicaly you still feel pretty strangeafter an adventure like pssd. Yours sincerely --- Original

Message ----To: SSRIsex Sent: Tuesday, January 29, 2008 9:32:47 AMSubject: Re: almost healed with tianeptine (stablon)

Couple questions.

1) What is an appropriate daily dosage?

2) How can one get a hold of this since it is not available in the US?

Are sites like this one legal or reputable?

http://www.your- onlinepharmacy. com/dr/n/ Tianeptine. shtml

Seems shady to me. But even if my doctor was cool with it, I don't

know how or where I'd get it that would be any different.

3) Does anyone know if this would be relevant to the sort of PSSD that

includes low testosterone levels? Did the first poster have low

testosterone levels? Any theories?

>

> rite, all my research so far points towa

rds ssris depleting serotonin

> from neurons, while you were on ssris the uptake of serotonin into

> the neurons was inhibited.

>

> you released serotonin into synapsis when you had a thought or

> experienced an emotion, this serotonin was prevented form re-entering

> the neurons that it came from. mao destroyed the serotonin that the

> ssri's prevented from re-entering the neurons. thus creating a

> depletion of serotonin in the actual neuron its self for future use.

>

> when serotonin is released from a neuron in a normal processes (with

> out ssri) 10% is broken down by mao, the remaining 90% is what should

> have been recycled back into the neuron through the serotonin

> transporter (sert) that the ssri has blocked. its reasonable to

> assume the 10%lost during normal functioning is replaced through

> dietary consumption of tryptophan, this 10% at most is what the

> ssri's left us with after we discontinued the treatment. (this is not

> enough)(would it be fair to say ssris left us with 10% or less

> sexuality?)

>

> also its the re-uptake of serotonin into the neuron that synthesizes

> neural nitric oxide (this is prevented by the ssri) and we are left

> with so little presynaptic serotonin that reuptake of that small

> ammount isnt enough to stimulate enough neural nitric oxide, when you

> get an erection its neuronal nitric oxide that is released from the

> nerves in the penis that then triggers a rush of blood into the penis

> that then triggers more nitric oxide to be released from endothelial

> cells in the penis. that first neural nitric oxide signal came from

> the brain, so its likely that uptake of serotonin had something to do

> with this signal, (the ssri disrupted this because it prevents uptake

> of serotonin.)

>

>

> its unclear to me what would happen to a neuron that is depleted of a

> neurotransmitter, but i suppose its reasonable to assume it takes on

> a smaller structure and possibly grows new connections in an attempt

> to compensate.( neuroplasticity)

>

> if its not clear to any of you what im on about with all this, here

> it is in simplest terms. the ssri took serotonin out of your brain

> and was the instigator of its destruction. this drug puts it back.

>

> another thing thats good about this drug is its half life is only 2.5

> hours so it would be easy to start low and build up then ween off.

>

>

> http://en.wikipedia .org/wiki/ Tianeptine

>

> http://www.servier. com/pro/Neurosci ences/stablon/ stablon_press. asp

>

> http://www.servier. com/pro/Neurosci ences/stablon/ stablon_video. asp

>

Be a better friend, newshound, and know-it-all with Yahoo! Mobile. Try it now.

Link to comment
Share on other sites

I plan to contine Tianeptine for 4 to 12 months, my doctor will decide Re: almost healed with tianeptine (stablon)

I'm very intrigued:

Are there any similar drugs that are easier to get a hold of in the USA?

The recent posts on Tianeptine particularly intrigue me because my

anxiety has lowered along with my blunted emotional and sexual

feeling, and increased anxiety is one of the possible side effects of

this drug which basically does the opposite of an SSRI. Hmm...

I'm very interested in any theory of how this drug might or might not

effect my testosterone level (keeping in mind that I am currently

below normal range).

www.Tianeptine. com offers some VERY interesting suggestions:

"Current evidence suggests that tianeptine acts to prevent and even

reverse stress-induced neural damage, promoting both neuronal survival

and synaptic plasticity. Sustained use of tianeptine tends to

"normalise" the hypothalamic- pituitary- adrenal (HPA) system."

"The side-effect profile of tianeptine is unusually benign."

"Since melancholic depression is strongly associated with

hypercortisolaemia, which tianeptine reverses, tianeptine may in fact

offer comparable long-term protection against relapse and recurrence."

"Unlike SSRIs and other "serotonergic" antidepressants, tianeptine

does not dampen libido or sexual performance. Indeed sexual function

may even be enhanced."

This seems very promising indeed.

Unfortunately, it also costs a freaking fortune and no help from

insurance is in sight...

How'd you pay for it? Do you plan on staying on it indefinitely?

Please let us know what happens if you discontinue treatment.

~

>

>

> Dear all,

>

> I started tianeptine on 2nd of january, and

> my health improved gradually over 4 weeks. Now

> I feel almost biologically healed:

> -Normal emotions (before I had no emotions at all)

> -Normal good skin sensitivity (before i was afraid to be touched).

> -Gained command again over my body (can do some jogging again,

> before I was not able do do and enjoy any effort). Before my

> body felt that bad that i thought it was not mine anymore and

> my doctor thought that I had schizophrenia

> -I have much less depersonalization, but I still feel a bit strange

> -I read again newspapers, books

> -I have no more problems to control my urine(before I had a little

> bit problems)

> -can have some nice sex again, and getting an orgasm is nice again.

> -have some libido (girls are more erotic than trees again)

> -I can sleep again (before I sometimes slept only 2hours and

> when taking Risperdal I slept very much)

> -I am not that anxious anymore (no more free floating fear)

> -my apetite is normal again

>

> I hope my health will not deteriorate again

>

> I don't know whether I had PSSD, a clinical depression or

> schizophrenia, or some mixture of all these illnesses, but my

> Illness started one week after I took seroxat (a ssri), almost

> two years ago

> I don't even know if most of the people here have the same

> illness or if everyone is a different case, as I am one of

> the only ones who improved with tianeptine.

>

> Maybe psychology and god played also a big part in the improvement,

> first my trust in god improved, then faith in myself came back,

> then I did more resarch on the internet, and thought that

> tianeptine fitted my symptoms best, and I calculated (sorry I was

> a mathematician) that the probability that I had no schizophrenia

> but that it was more clinical depression was one in five (probability

> my doctor was wrong), and that tianeptine could cure that depression

> given that i had a depression was one in five too, so the probability

> to get "healed" by tianeptine was on in 25, thus I was quite lucky.

> I was also lucky my doctor was very nice and said that i could try

> tianeptine

> Regards and thanks for all your support and help

>

> Jean

>

Never miss a thing. Make Yahoo your homepage.

Link to comment
Share on other sites

without risperdal I had no apetite, and no sleep.

with risperdal I had a huuuge apetite and 11h sleep a day,

but from a psychiatric point of view riperdal did not help me

(no effects on emotional numbness, body sensitivity,

libido was bad (not better than pssd), very difficult orgasms,

retrograde ejaculation)

>

> >

> > Dear all,

> >

> > I started tianeptine on 2nd of january, and

> > my health improved gradually over 4 weeks. Now

> > I feel almost biologically healed:

> > -Normal emotions (before I had no emotions at all)

> > -Normal good skin sensitivity (before i was afraid

> > to be touched).

> > -Gained command again over my body (can do some

> > jogging again,

> > before I was not able do do and enjoy any

> > effort). Before my

> > body felt that bad that i thought it was not mine

> > anymore and

> > my doctor thought that I had schizophrenia

> > -I have much less depersonalization, but I still

> > feel a bit strange

> > -I read again newspapers, books

> > -I have no more problems to control my

> > urine(before I had a little

> > bit problems)

> > -can have some nice sex again, and getting an

> > orgasm is nice again.

> > -have some libido (girls are more erotic than

> > trees again)

> > -I can sleep again (before I sometimes slept only

> > 2hours and

> > when taking Risperdal I slept very much)

> > -I am not that anxious anymore (no more free

> > floating fear)

> > -my apetite is normal again

> >

> > I hope my health will not deteriorate again

> >

> > I don't know whether I had PSSD, a clinical

> > depression or

> > schizophrenia, or some mixture of all these

> > illnesses, but my

> > Illness started one week after I took seroxat (a

> > ssri), almost

> > two years ago

> > I don't even know if most of the people here have

> > the same

> > illness or if everyone is a different case, as I am

> > one of

> > the only ones who improved with tianeptine.

> >

> > Maybe psychology and god played also a big part in

> > the improvement,

> > first my trust in god improved, then faith in myself

> > came back,

> > then I did more resarch on the internet, and thought

> > that

> > tianeptine fitted my symptoms best, and I calculated

> > (sorry I was

> > a mathematician) that the probability that I had no

> > schizophrenia

> > but that it was more clinical depression was one in

> > five (probability

> > my doctor was wrong), and that tianeptine could cure

> > that depression

> > given that i had a depression was one in five too,

> > so the probability

> > to get " healed " by tianeptine was on in 25, thus I

> > was quite lucky.

> > I was also lucky my doctor was very nice and said

> > that i could try

> > tianeptine

> > Regards and thanks for all your support and help

> >

> > Jean

> >

> >

> >

> > This group is for support, discussion, or

> > educational purposes only. It does not provide

> > psychiatric or medical care. All medications and

> > supplements should be taken under a doctor's

> > supervision.

> >

Link to comment
Share on other sites

so you were on risperdal for 16 months at how many

milligrams? What is your libido compared to before

drugs based on a 1-10 scale?

Are you in the UK or outside the US b/c its not

prescribed here but you can still get it online and

sent here. I'm assuming you are outside the US b/c

that drug isn't FDA approved here and you can't get a

script for it here yet although it is trying to get

approval for IBS in the states i read but not sure how

that is going...

--- jonny_man19 wrote:

> without risperdal I had no apetite, and no sleep.

> with risperdal I had a huuuge apetite and 11h sleep

> a day,

> but from a psychiatric point of view riperdal did

> not help me

> (no effects on emotional numbness, body

> sensitivity,

> libido was bad (not better than pssd), very

> difficult orgasms,

> retrograde ejaculation)

>

>

>

> >

> > >

> > > Dear all,

> > >

> > > I started tianeptine on 2nd of january, and

> > > my health improved gradually over 4 weeks. Now

> > > I feel almost biologically healed:

> > > -Normal emotions (before I had no emotions at

> all)

> > > -Normal good skin sensitivity (before i was

> afraid

> > > to be touched).

> > > -Gained command again over my body (can do

> some

> > > jogging again,

> > > before I was not able do do and enjoy any

> > > effort). Before my

> > > body felt that bad that i thought it was not

> mine

> > > anymore and

> > > my doctor thought that I had schizophrenia

> > > -I have much less depersonalization, but I

> still

> > > feel a bit strange

> > > -I read again newspapers, books

> > > -I have no more problems to control my

> > > urine(before I had a little

> > > bit problems)

> > > -can have some nice sex again, and getting an

> > > orgasm is nice again.

> > > -have some libido (girls are more erotic than

> > > trees again)

> > > -I can sleep again (before I sometimes slept

> only

> > > 2hours and

> > > when taking Risperdal I slept very much)

> > > -I am not that anxious anymore (no more free

> > > floating fear)

> > > -my apetite is normal again

> > >

> > > I hope my health will not deteriorate again

> > >

> > > I don't know whether I had PSSD, a clinical

> > > depression or

> > > schizophrenia, or some mixture of all these

> > > illnesses, but my

> > > Illness started one week after I took seroxat (a

> > > ssri), almost

> > > two years ago

> > > I don't even know if most of the people here

> have

> > > the same

> > > illness or if everyone is a different case, as I

> am

> > > one of

> > > the only ones who improved with tianeptine.

> > >

> > > Maybe psychology and god played also a big

> part in

> > > the improvement,

> > > first my trust in god improved, then faith in

> myself

> > > came back,

> > > then I did more resarch on the internet, and

> thought

> > > that

> > > tianeptine fitted my symptoms best, and I

> calculated

> > > (sorry I was

> > > a mathematician) that the probability that I had

> no

> > > schizophrenia

> > > but that it was more clinical depression was one

> in

> > > five (probability

> > > my doctor was wrong), and that tianeptine could

> cure

> > > that depression

> > > given that i had a depression was one in five

> too,

> > > so the probability

> > > to get " healed " by tianeptine was on in 25, thus

> I

> > > was quite lucky.

> > > I was also lucky my doctor was very nice and

> said

> > > that i could try

> > > tianeptine

> > > Regards and thanks for all your support and

> help

> > >

> > > Jean

> > >

> > >

> > >

> > > This group is for support, discussion, or

> > > educational purposes only. It does not provide

> > > psychiatric or medical care. All medications

> and

> > > supplements should be taken under a doctor's

> > > supervision.

> > >

Link to comment
Share on other sites

you take 3 pills per day personally i would start with a lower dose

than that and work up then down.

try here

http://www.drugdelivery.ca/s33961-s-STABLON.aspx

> >

> > rite, all my research so far points towa

>

> rds ssris depleting serotonin

> > from neurons, while you were on ssris the uptake of serotonin

into

> > the neurons was inhibited.

> >

> > you released serotonin into synapsis when you had a thought or

> > experienced an emotion, this serotonin was prevented form re-

entering

> > the neurons that it came from. mao destroyed the serotonin that

the

> > ssri's prevented from re-entering the neurons. thus creating a

> > depletion of serotonin in the actual neuron its self for future

use.

> >

> > when serotonin is released from a neuron in a normal processes

(with

> > out ssri) 10% is broken down by mao, the remaining 90% is what

should

> > have been recycled back into the neuron through the serotonin

> > transporter (sert) that the ssri has blocked. its reasonable to

> > assume the 10%lost during normal functioning is replaced through

> > dietary consumption of tryptophan, this 10% at most is what the

> > ssri's left us with after we discontinued the treatment. (this is

not

> > enough)(would it be fair to say ssris left us with 10% or less

> > sexuality?)

> >

> > also its the re-uptake of serotonin into the neuron that

synthesizes

> > neural nitric oxide (this is prevented by the ssri) and we are

left

> > with so little presynaptic serotonin that reuptake of that small

> > ammount isnt enough to stimulate enough neural nitric oxide, when

you

> > get an erection its neuronal nitric oxide that is released from

the

> > nerves in the penis that then triggers a rush of blood into the

penis

> > that then triggers more nitric oxide to be released from

endothelial

> > cells in the penis. that first neural nitric oxide signal came

from

> > the brain, so its likely that uptake of serotonin had something

to do

> > with this signal, (the ssri disrupted this because it prevents

uptake

> > of serotonin.)

> >

> >

> > its unclear to me what would happen to a neuron that is depleted

of a

> > neurotransmitter, but i suppose its reasonable to assume it takes

on

> > a smaller structure and possibly grows new connections in an

attempt

> > to compensate.(neuroplasticity)

> >

> > if its not clear to any of you what im on about with all this,

here

> > it is in simplest terms. the ssri took serotonin out of your

brain

> > and was the instigator of its destruction. this drug puts it back.

> >

> > another thing thats good about this drug is its half life is only

2.5

> > hours so it would be easy to start low and build up then ween off.

> >

> >

> > http://en.wikipedia.org/wiki/Tianeptine

> >

> > http://www.servier.com/pro/Neurosciences/stablon/stablon_press.asp

> >

> > http://www.servier.com/pro/Neurosciences/stablon/stablon_video.asp

> >

>

Link to comment
Share on other sites

I think its more complex than merealy " reversing the ssri effects " if

you see what I mean.

I think stablon increases nitric oxide synthase.

I think it also reduces cortisol (stress hormones).

When you've got lower cortisol, your neurons can repair more naturally.

Also, when you have more nitric oxide in your body, you can get

erections more naturually.

Link to comment
Share on other sites

That's great news.

I've been doing some research into stablon as well.

I think the mechanism by which stablon works is by indirectly reducing

cortisol. That means that stress is lowered. Also, because cortisol is

less, your neurons may be able to repair themselves better.

Its good that you've been jogging. I think jogging helps to repair

various neurons, and also increaes DA nad serotonin release. I'd

recommend that you keep joggin as much as possible whilst taking

stablon.

Stablon also increases Nitric Oxide synthase, and therefore has a kind

of viagra like effect.

Let us know if things improve in future.

Link to comment
Share on other sites

I think its possible that drinkng lots of decaf tea and green tea, a

bit of nomi juice exercising a lot may actually have similar effects to

taking stablon (believe it or not).

I think we can possibly find a herbal equivalent to stablon thats

easier to get hold of therefore.

Link to comment
Share on other sites

have you got any rational for that theory?

i ordered the stablon 3 days ago and it came today by dhl.

>

> I think its possible that drinkng lots of decaf tea and green tea, a

> bit of nomi juice exercising a lot may actually have similar effects

to

> taking stablon (believe it or not).

>

> I think we can possibly find a herbal equivalent to stablon thats

> easier to get hold of therefore.

>

Link to comment
Share on other sites

what ive read about stablon is that it induces reupatke of serotonin,

by and unknown pathway thought to be independent of sert.

is your theory about high cortisol being a problem because ssris

increase cortisol levels while your on them?

>

> That's great news.

>

> I've been doing some research into stablon as well.

>

> I think the mechanism by which stablon works is by indirectly

reducing

> cortisol. That means that stress is lowered. Also, because cortisol

is

> less, your neurons may be able to repair themselves better.

>

> Its good that you've been jogging. I think jogging helps to repair

> various neurons, and also increaes DA nad serotonin release. I'd

> recommend that you keep joggin as much as possible whilst taking

> stablon.

>

> Stablon also increases Nitric Oxide synthase, and therefore has a

kind

> of viagra like effect.

>

> Let us know if things improve in future.

>

Link to comment
Share on other sites

a better way to explain it would be the more serotonin you have in your

neurons that is released into the synapse then transported back into

the neurons by sert increases nitric oxide in the brain.

>

> I think its more complex than merealy " reversing the ssri effects " if

> you see what I mean.

>

> I think stablon increases nitric oxide synthase.

>

> I think it also reduces cortisol (stress hormones).

>

> When you've got lower cortisol, your neurons can repair more

naturally.

> Also, when you have more nitric oxide in your body, you can get

> erections more naturually.

>

Link to comment
Share on other sites

Hi You are right jogging is good. Before taking Seroxat and getting very sick afterwardsI had things like situational depession. That wentaway with Sports, after 70min Jogging I didn't feel anything anymore. However if I wanted to improve my overall feeling of beeing well for a long time I needed to do LOTS of sports, i.e. do 3 weeks of cycling, cycling 7h a day.But when being sick my mind could not control my body anymore, thus I could not do LOTS of sports,but now I will try again in the summer Regards

JeanPS: If Sports does you make feel good, then do LOTS of sports, and afterwards I think your brain might work in different ways Re: almost healed with tianeptine (stablon)

That's great news.

I've been doing some research into stablon as well.

I think the mechanism by which stablon works is by indirectly reducing

cortisol. That means that stress is lowered. Also, because cortisol is

less, your neurons may be able to repair themselves better.

Its good that you've been jogging. I think jogging helps to repair

various neurons, and also increaes DA nad serotonin release. I'd

recommend that you keep joggin as much as possible whilst taking

stablon.

Stablon also increases Nitric Oxide synthase, and therefore has a kind

of viagra like effect.

Let us know if things improve in future.

Be a better friend, newshound, and know-it-all with Yahoo! Mobile. Try it now.

Link to comment
Share on other sites

Yes I think its possible that whilst taking ssris your cortisol levels

raise.

That's why you can get back ache and headache and other pains whilst on

ssris.

What would make it even worse is drinking coffee or smoking whilst on

ssris, or getting poor sleep.

I beleive large amounts of cortisol can damage the neurons and the

synapses.

There is some proof that ssrs damage the synapses isn't there?

It could also be that large amounst of serotonin (particularly during

serotonin syndrome) could damage the synapses.

If what you have said is true, this could cause a problem with Nitric

Oxide Synthase.

Link to comment
Share on other sites

I think you're right. Vigorous exercise is the best. If you have low T

levels, avoid cycling though.

Over time, exercise can help to improve some of the damage caused by

cortisol etc.

I think certain things will help you to get back into exercise. For

instance, decaf tea, orange juice. In particular I think stablon plus

exercise will help people to recover. I hope that it is released in

more countries soon.

Link to comment
Share on other sites

The decaf tea will help to lower cortisol, and the nomi juice will help

to raise Nitric Oxide. I'll let you know how the Nitro FX works. I'm

hoping I can mix it with my vitamin E coconut moisturiser and use it as

a cream that will repair damaged nerve endings.

Drinking lots of decaf tea whilst exercising will help to repair

damaged neurons. Of course, stablon will have the same effect. Whatever

yuo're taking make sure you exercise a lot, I think its crucial for

long term benefits. It has to be really intense exericise like running.

I have noticed that you can get stablon pretty chep though. Its

possible that if you get a reference from your doc you might even be

able to get it legal, but Im not sure about that?

Link to comment
Share on other sites

if its true that cortisol rises while your on ssri's then when you

come off them that rise will be followed by a drop lower that it was

before the ssri's, cortisol form the adreanals will down regulate

through feedback inhibition, just like if you take cortisol or use

high strength cortisol creams.

i dont think high cortisol is the cause of pssd it probably wont help

but many people including myself only got pssd while on the

medication for short ammount of time, two weeks or there about in my

case. i dont think this ammount of time is enough as people take

cortisol and use cortisol steroid creams for longer periods without

any pssd symptoms.

if theres proof that ssris damage synapses i haven't read it, but if

you remember my theory on what ssri's actually do and considering

theres a fluorine molecule attached to the ssri's then im sure damage

of some sorts is taking place, but im sure its got more to do with

the ssri being able to inhibit neural nitric oxide synthesis and it

binding to sert which is involved in neural nitric oxide synthesis.

theres probably direct inhibition of nitric oxide on sert and the

fact that reuptake of serotonin is how the brain synthesis nitric

oxide then both things are probably the culprit. (psychologically)

physically its probably inhibition of nitric oxide outside the blood

brain barrier (endothelial) theres another form of n.o in the body 3

in total i forget what the other one is called.

large amounts of serotonin between the synapse could be something

that damages the neurons, but i know survivor has theory that the

ssri cannot distinguish between binding to sert or to a receptor on

the neuron, there could be some truth in this. perhaps its also a

receptor agonist.

note that serotonin in the body cannot pass the blood brain barrier.

>

> Yes I think its possible that whilst taking ssris your cortisol

levels

> raise.

>

> That's why you can get back ache and headache and other pains

whilst on

> ssris.

>

> What would make it even worse is drinking coffee or smoking whilst

on

> ssris, or getting poor sleep.

>

> I beleive large amounts of cortisol can damage the neurons and the

> synapses.

>

> There is some proof that ssrs damage the synapses isn't there?

>

> It could also be that large amounst of serotonin (particularly

during

> serotonin syndrome) could damage the synapses.

>

> If what you have said is true, this could cause a problem with

Nitric

> Oxide Synthase.

>

Link to comment
Share on other sites

where did you get the nitro fx from? ive been trying to order it and

cant.

i recomend with stablon or with out, you take arginine or arginine

pyroglutamate, or eat wall nuts for arginine.

drink milk for tryptophan.

take the b vitamins b1 b2 b6 for processing of amino acids in to

neurotransmitters.

the noni juice might have everything in it to form neural nitric

oxide and it may cross the blood brain barrier.

this combination should give all thats needed for neuronal release of

serotonin and uptake of serotonin to synthesise nitric oxide which

arginine is needed for across the blood brain barrier.

>

> The decaf tea will help to lower cortisol, and the nomi juice will

help

> to raise Nitric Oxide. I'll let you know how the Nitro FX works.

I'm

> hoping I can mix it with my vitamin E coconut moisturiser and use

it as

> a cream that will repair damaged nerve endings.

>

> Drinking lots of decaf tea whilst exercising will help to repair

> damaged neurons. Of course, stablon will have the same effect.

Whatever

> yuo're taking make sure you exercise a lot, I think its crucial for

> long term benefits. It has to be really intense exericise like

running.

>

> I have noticed that you can get stablon pretty chep though. Its

> possible that if you get a reference from your doc you might even

be

> able to get it legal, but Im not sure about that?

>

Link to comment
Share on other sites

Join the conversation

You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...