Re: Central nervous system-acting agents

[Guest guest]

ok lisa im one and a half days in and so far so good!!!!

In SSRIsex , lisa hallford wrote:

>

> Great job, nemo! I know its hard--its probably WAY

> more difficult for men--so far so good!!! Keep up the

> good work! No pun intended.

> lisa

> --- " nemo.shark " wrote:

>

> > what ive read about is the prolactin dopamine up

> > down relationship

> > and its effects on sexual addiction, im sure it said

> > two weeks to

> > stop this from driving your desires and after two

> > weeks you will be

> > able to think more clearly about things...

> >

> >

> > " It would be a wonderful break to not stress about

> > our organs or even

> > think about them at all for a month. "

> >

> > ive tried this abstaining thing before 3 times and

> > only managed 5

> > days maximum, i agree it would be a break from

> > thinking about it and

> > experimenting.

> >

> > however my experiences from trying this in the past

> > tell me that its

> > very difficult to not think about it when your

> > trying this!!!!

> >

> > i even thought about it more and more and it was

> > difficult to say the

> > least, thats when i read up on dopamine and

> > prolactin being the

> > driving force behind your sex drive.

> >

> > two weeks is what it said you need to get through to

> > make you think

> > more clearly about it and i would say thats about

> > rite, 28 days is

> > probably what it takes to break an adiction.

> >

> > im willing to give this a go, but as i am just

> > starting to see some

> > improvement with sexuality sensitivity and ability

> > its going to be

> > really really difficult for me!!!!

> >

> > i woke this morning with an erection and left it

> > alone, so you could

> > say im half way through one day already.

> >

> > and yes morning erections do usually go away after

> > urination, but you

> > have to get the erection down before you can urinate

> > properly, but it

> > can be done....

> >

> > i can feel my self already biting my finger nails at

> > attempting this

> > and i never bite them ever....

> >

> > just to conclude i will attempt this but theres no

> > way i think i can

> > make it past my 5 day record, but if i do i will be

> > pleased and if

> > this is the way to a cure then im going to consider

> > joining the navy

> > and spending a few years on a nuclear sub.....

> >

> > p.s. it would be good if another guy can attempt

> > this with me....

> >

> >

> > > > >

> > > > > OH and probably someone who isnt on any

> > > > medications or

> > > > > herbal remedies to skew the results or affect

> > > > sexual

> > > > > functioning at all. Cold turkey in all areas.

> > Is

> > > > there

> > > > > anyone?? Please??

> > > > > lisa

> > > > >

> > > > >

> > > > >

> > > >

> > >

> >

>

______________________________________________________________________

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> > > > >

> > > >

> > > >

> > > >

> > >

> > >

> > >

> > >

> >

>

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[Guest guest]

i agree it could be that the ssris have left us a sexually obese

state and we need to go on a diet!!

i know what you mean about having to think thoughts that are just not

what you would usually have to think about to get a reaction!!!!

before pssd even the most sutle or suggestive thing would provoke a

physical reaction that would just take over all other thought process.

and now it the really deep hard core thoughts that only have a

reaction and just a reaction that isnt even long lasting enough....

maybe if we do leave it a while your brain receptors would be more

susceptive to those more sutle thoughts...

>

> > I am willing to try 's idea. Though my question

> > for is " why do you

> > think this will work? " It's worth a try, but I don't

> > have any particular

> > reason to think that it will reverse PSSD. I hope

> > it works, anything is worth a

> > try.

> >

> >

> >

> >

> >

> >

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[Guest guest]

http://en.wikipedia.org/wiki/Flibanserin

http://www.foxnews.com/story/0,2933,262784,00.html

A drug to boost female sex drive could be worth billions to the

company that manages to get it approved by the Food and Drug

Administration. Recently, two new treatments have made strides towards

that goal. ­­­But some are skeptical of the real value of such a drug

to the women it's supposed to help.

In late 2004, FDA approval of Intrinsa, a testosterone patch for low

female sex drive, seemed imminent. News reports heralded Intrinsa as a

" Viagra for her, " suggesting that it would revolutionize sexual health

for women just as erectile dysfunction pills had for men.

Except an FDA advisory panel saw things differently. Finding numerous

problems with the evidence for the drug's effectiveness and safety,

experts on the panel voted against approving it. Procter & Gamble, the

company responsible for Intrinsa, withdrew its application. Procter &

Gamble is a WebMD sponsor.

Now the frontrunner in the race to market the first prescription drug

for low female sex drive is Boehringher-Ingelheim Pharmaceuticals. It

has a drug called flibanserin in phase III clinical trials, the final

phase of drug testing required for FDA approval. The company is a

WebMD sponsor.

>

> Central nervous system-acting agents and the treatment of erectile and

> sexual dysfunction.

> Carson CC 3rd.

>

> Division of Urology, School of Medicine, University of North Carolina

> at Chapel Hill, 2140 Bioinformatics Building, Chapel Hill, NC 27599,

> USA. culley_carson@...

>

> Recent animal studies have resulted in newer central nervous system

> (CNS)-acting agents for the treatment of sexual dysfunction in men and

> women. CNS stimulation and control of sexual function primarily

> originates in the hypothalamus, medial preoptic area, and

> paraventricular nucleus. Neurotransmitters responsible for sexual

> function, such as serotonin, dopamine, and oxytocin, can be

> manipulated pharmacologically. Early clinical trials and use of

> apomorphine have shown limited success and acceptance among patients,

> especially after the introduction of agents with improved efficacy and

> tolerability such as phosphodiesterase type 5 inhibitors. Newer

> CNS-acting agents such as bremelanotide show significant promise in

> bringing to clinical practice a group of centrally acting agents to

> supplement the treatment of erectile dysfunction. CNS-acting agents

> also show promise in treating female sexual dysfunction. Further,

> development of selective dopamine receptor agonists, melatonin

> agonists, and other CNS stimulatory or inhibitory agents may lead to

> improved treatment of sexual dysfunction in men and women.

>

> PMID: 18042327 [PubMed - in process]

>

[Guest guest]

I believe that this is the answer to PSSD. The part of the central

nervous system that Nemo was talkign about is responsible for the

nicotinic and muscarinic systems (thereby giving you the ability to

cry).

It is also responsible for the signalling of nitiric oxide. This means

that it allows you to get " spontanious " erections. ie. you can get

erectiosn without struggling.

Futhermore, it helps to signal systems such as dopamine and adrenaline.

I have tried drugs that effect the nicotinic, muscarinic, dopamine and

nitric oxide systems. None of them are much use.

I think that Nemo inadvertanly found out that the real problem is that

all of these symptoms have been downregulated.

If you look at the article that I posted on inability to cry, that also

suggests that there is a problem with this whole area of the central

nervous system.

I think the real problem may be problems with tyrosone kinase, or

overstimulation of that part of the nervosu system.

http://en.wikipedia.org/wiki/Tyrosine_kinase

[Guest guest]

I belive that PSSD is caused by an interference in NO signalling and

the tyrosine kinase system.

There is a new drug in 3rd stage of development which will stop this

prooblem.

A similar drug, melatonin 2 has already been proven to be effective

at treating pssd. More effective than any other pharmacutical I

believe. Similarly, other drugs that effect the central nervous

system in similar ways, such as MDMA are also effective at treating

PSSD. I hope that this drug will be available for release soon.

Pharmaceutical aphrodisia. Almost a decade ago, 43% of women and 31%

of men in the United States were believed to suffer from one form or

another of sexual dysfunction [1]. Viagra™ and other

phosphodiesterase type 5 (PDE5) inhibitors have provided viable

pharmacological treatment options for men over the past decade.

However, these drugs lack efficacy in women, and similarly successful

drug treatments for female sexual dysfunction have yet to emerge [2].

Furthermore, despite the high efficacy and widespread tolerability of

PDE inhibitors in men, these drugs are not without drawbacks.

Headache and vision-related side effects are present in some

individuals, and these drugs are contraindicated in patients

concurrently taking nitrates or related drugs that may carry

hypotension risks [3]. Additionally, it is estimated that half of men

prescribed sildenafil (Viagra™) subsequently cease use over time [4].

Bremelanotide (formerly PT-141), a drug currently under development

by Palatin Technologies [5], could prove a novel and effective

treatment for female and male sexual dysfunction. The main reason

underlying the drug's potential efficacy in both sexes lies in its

CNS-acting mechanism. Bremelanotide is a cyclic heptapeptide

melanocortin analog, which acts as an agonist at the primarily CNS-

expressed melanocortin receptors, MC3-R and MC4-R [6, 7]. The

mechanism by which melanocortin receptor activation mediates sexual

arousal and behavior is not well established; however, it likely

involves an increase in nitric oxide signaling in the CNS [7].

Central activation of the melanocortin receptors by known agonist

such as alpha-melanocyte-stimulating hormone (alpha-MSH) causes

increased sexual arousal and mating behavior in animals [8].

Likewise, the synthetic melanocortin analog Melanotan-II, which is

structurally similar to Bremelanotide (and is the parent compound

from which the latter was derived), induces penile erection in men

suffering from erectile dysfunction (ED) [9]. Rodent and non-human

primate studies demonstrate a potent erection-promoting effect of

Bremelanotide [10]. Women with female sexual arousal disorder given

Bremelanotide (by intranasal delivery) report significantly increased

sexual desire after treatment, as well as more satisfaction with

their level of arousal when attempting intercourse within 24 hours

[11]. In both normal and ED men, treatment with Bremelanotide causes

significant increases in erectile activity, in a dose-dependant

manner [10]. Clinically and statistically effective doses of the drug

(up to 20mg) are safe and well tolerated by both normal and ED

patients [12]. Having completed all Phase II trials in men with

promising results, Bremelanotide is set to enter Phase III for men in

the first half of this year. In women, positive data from a Phase IIa

trial and the recent commencement of a Phase IIb trial suggest that

entry to Phase III for women may also be on the horizon. If approved,

Bremelanotide would be the first FDA-approved synthetic aphrodisiac.

This novel therapy could potentially address the substantial need for

an effective female sexual dysfunction treatment as well as offer an

alternative to traditional PDE inhibition in ED men

[Guest guest]

i can cry just not while im thinking about pssd even though im really

upset about it.

i watched saving private and armageddon they always get me at

the end with a few tears. try it!

its like suggestion gets through to an emotional response, if

somthing in the real world happened to make me cry i probably

wouldn't or would have to force it.

has anyone tried hypnosis with pssd?

also it might be a good idea if some other people come up with

suggestions of films that can shed tears.

>

> I believe that this is the answer to PSSD. The part of the central

> nervous system that Nemo was talkign about is responsible for the

> nicotinic and muscarinic systems (thereby giving you the ability to

> cry).

>

> It is also responsible for the signalling of nitiric oxide. This

means

> that it allows you to get " spontanious " erections. ie. you can get

> erectiosn without struggling.

>

> Futhermore, it helps to signal systems such as dopamine and

adrenaline.

>

> I have tried drugs that effect the nicotinic, muscarinic, dopamine

and

> nitric oxide systems. None of them are much use.

>

> I think that Nemo inadvertanly found out that the real problem is

that

> all of these symptoms have been downregulated.

>

> If you look at the article that I posted on inability to cry, that

also

> suggests that there is a problem with this whole area of the

central

> nervous system.

>

> I think the real problem may be problems with tyrosone kinase, or

> overstimulation of that part of the nervosu system.

> http://en.wikipedia.org/wiki/Tyrosine_kinase

>

[Guest guest]

ive been on the drug you mention its far from a cure for pssd, it

does make you think more sexual and it will give you the hardest

throbbing erection imagineable, but the effects ware off over time.

if you want to try it i can put you a link up where you can get it,

you have to inject it though.

i was dubious about trying this peptide but i had a lab in the uk do

an independent analysis of the peptide before i used it. it was over

95% pure.

p.s. when you inject it you will get an errection in about 20 mins

and its not caused by your own thoughts.

>

> I belive that PSSD is caused by an interference in NO signalling and

> the tyrosine kinase system.

>

> There is a new drug in 3rd stage of development which will stop this

> prooblem.

>

> A similar drug, melatonin 2 has already been proven to be effective

> at treating pssd. More effective than any other pharmacutical I

> believe. Similarly, other drugs that effect the central nervous

> system in similar ways, such as MDMA are also effective at treating

> PSSD. I hope that this drug will be available for release soon.

>

>

> Pharmaceutical aphrodisia. Almost a decade ago, 43% of women and 31%

> of men in the United States were believed to suffer from one form or

> another of sexual dysfunction [1]. Viagra™ and other

> phosphodiesterase type 5 (PDE5) inhibitors have provided viable

> pharmacological treatment options for men over the past decade.

> However, these drugs lack efficacy in women, and similarly

successful

> drug treatments for female sexual dysfunction have yet to emerge

[2].

> Furthermore, despite the high efficacy and widespread tolerability

of

> PDE inhibitors in men, these drugs are not without drawbacks.

> Headache and vision-related side effects are present in some

> individuals, and these drugs are contraindicated in patients

> concurrently taking nitrates or related drugs that may carry

> hypotension risks [3]. Additionally, it is estimated that half of

men

> prescribed sildenafil (Viagra™) subsequently cease use over time

[4].

> Bremelanotide (formerly PT-141), a drug currently under development

> by Palatin Technologies [5], could prove a novel and effective

> treatment for female and male sexual dysfunction. The main reason

> underlying the drug's potential efficacy in both sexes lies in its

> CNS-acting mechanism. Bremelanotide is a cyclic heptapeptide

> melanocortin analog, which acts as an agonist at the primarily CNS-

> expressed melanocortin receptors, MC3-R and MC4-R [6, 7]. The

> mechanism by which melanocortin receptor activation mediates sexual

> arousal and behavior is not well established; however, it likely

> involves an increase in nitric oxide signaling in the CNS [7].

> Central activation of the melanocortin receptors by known agonist

> such as alpha-melanocyte-stimulating hormone (alpha-MSH) causes

> increased sexual arousal and mating behavior in animals [8].

> Likewise, the synthetic melanocortin analog Melanotan-II, which is

> structurally similar to Bremelanotide (and is the parent compound

> from which the latter was derived), induces penile erection in men

> suffering from erectile dysfunction (ED) [9]. Rodent and non-human

> primate studies demonstrate a potent erection-promoting effect of

> Bremelanotide [10]. Women with female sexual arousal disorder given

> Bremelanotide (by intranasal delivery) report significantly

increased

> sexual desire after treatment, as well as more satisfaction with

> their level of arousal when attempting intercourse within 24 hours

> [11]. In both normal and ED men, treatment with Bremelanotide causes

> significant increases in erectile activity, in a dose-dependant

> manner [10]. Clinically and statistically effective doses of the

drug

> (up to 20mg) are safe and well tolerated by both normal and ED

> patients [12]. Having completed all Phase II trials in men with

> promising results, Bremelanotide is set to enter Phase III for men

in

> the first half of this year. In women, positive data from a Phase

IIa

> trial and the recent commencement of a Phase IIb trial suggest that

> entry to Phase III for women may also be on the horizon. If

approved,

> Bremelanotide would be the first FDA-approved synthetic aphrodisiac.

> This novel therapy could potentially address the substantial need

for

> an effective female sexual dysfunction treatment as well as offer an

> alternative to traditional PDE inhibition in ED men

>

[Guest guest]

Yeah that would be great.

I will only try it as a last resort if nothing else works, because the

doctors still don't know what it does. I tried to understand what it

actually does. I think it probably upgrades everything in the whole

part of that nervous system is that right?