[CO-CURE]: Antioxidant and DNA protecting properties of anti-fatigue herb Tr

[Guest guest]

I tend to agree with this note from the Co-Cure moderators here.

Chronic fatigue is something many of us share in many illnesses. It

would be nice to even just get rid of that symptom; and who knows but where

that may lead? In fact; I am trying to think of one debilitating illness which

does not have chronic fatigue as as part of it - even those with fairly mild

MCS and allergies suffer it, especially when they get exposures.

Anybody have any experiance with this herb? Any herbalists around?

I had to read this slowly a couple of times to understand it - my

brain fog is back it seems. (did the laundry and have mold in the basement)

Blessings

Shan

[Note: Although  the symptom of " chronic fatigue " ought never to be

confused with what is currently termed chronic fatigue syndrome, this

article seems to merit the attention of the CFS community if only because

oxidative stress has been identified by some as contributing to the

pathogenesis of CFS and/or its continuation.]

Antioxidant and DNA protecting properties of

anti-fatigue herb

Trichopus zeylanicus

Journal: Phytother Res. 2005 Sep 21;19(8):669-673 [Epub ahead of print]

Authors: Binu Tharakan [1], Muralikrishnan Dhanasekaran [1 2], Bala V.

Manyam [1 2 *]

Affiliations:

[1] Department of Neurology, & White Clinic and Memorial Hospital;

, Sherwood and Brindley Foundation, Temple, Texas, USA

[2] The Texas A & M University System Health Science Center College of

Medicine, Temple, Texas, USA

[*] Correspondence to Bala V. Manyam, Department of Neurology, &

White Clinic/Texas A & M University, 2401 South 31st Street, Temple, Texas

76508, USA.

email: Bala V. Manyam

Funded by: Helen Vosburg McCrillus Plummer and Lee Plummer,

Jr. Endowed Fund

Keywords: Trichopus zeylanicus • chronic fatigue • antioxidants • DNA

protection • NADH • polyphenols

Abstract

Chronic fatigue is considered a complex symptom for which currently there

is no curative treatment available.

Oxidative stress plays an important role in the etiology of fatigue and

antioxidant treatment might be a valuable therapeutic approach. The Kani, a

tribal high altitude living population in southern India, traditionally use

the seeds of Trichopus zeylanicus to combat fatigue.

In this study, the antioxidant properties of Trichopus zeylanicus were

established on free radicals (DPPH and ABTS), its ability to reduce iron,

lipoxygenase activity and hydrogen peroxide-induced lipid peroxidation. The

effects of Trichopus zeylanicus on reactive oxygen species induced plasmid

DNA (pBR322) cleavage were also investigated.

Trichopus zeylanicus significantly scavenged free radicals, reduced lipid

peroxidation and inhibited lipoxygenase activity. Trichopus zeylanicus also

exhibited iron-chelating activity and inhibited reactive oxygen species

induced DNA damage. Trichopus zeylanicus contains NADH, polyphenols and

sulfhydryl compounds, which have the ability to scavenge reactive oxygen

species suggesting that the antioxidant activity may be an important

mechanism of action of Trichopus zeylanicus to combat fatigue.