Guest guest Posted October 4, 2005 Report Share Posted October 4, 2005 By Matt STOCKHOLM, Sweden -- Australians Barry Marshall and Robin Warren won the 2005 Nobel Prize in medicine on Monday for showing that bacterial infection, not stress, is to blame for most painful ulcers in the stomach and intestines. The 1982 discovery transformed peptic ulcer disease from a chronic, frequently-disabling condition to one that can be cured by a short regimen of antibiotics and other medicines, the Nobel Prize committee said. Thanks to their work, it has now been established that the bacterium Helicobacter pylori, which the new Nobel winners discovered, is the most common cause of peptic ulcers. " This was very much against the prevailing knowledge and dogma because it was thought that peptic ulcer disease was the result of stress and lifestyle, " Staffan Normark, a member of the Nobel Assembly at Karolinska institute, said at a news conference. The Australians' proposal of a microbial cause instead was very controversial and unexpected " , said Goran Hansson, who chairs the Nobel committee that awards the medicine or physiology prize. " They had to spend the first few years convincing the rest of the world. " Marshall even deliberately infected himself with the bacterium in 1985 and showed that it caused stomach illness, noted Lord May of Oxford, president of Britain's Royal Society. Marshall suffered inflammation, which can lead to ulcer. Marshall, 54, and Warren, 68, celebrated their new honour with champagne and beer. " Obviously it's the best thing that can ever happened to somebody in medical research. It's just incredible. " Marshall told the Associated Press by telephone from the Western Australian state capital, Perth, where the two men were celebrating with family members. Warren said he was " very excited also a little overcome, " at the honour. " The idea of stress and things like that [ causing ulcers ] was just so entrenched nobody could really believe that it was bacteria. " Marshall said. " It had to come from some weird place like Perth Western Australia, because I think nobody else would have even considered it. " The discovery has stimulated research into microbes as possible reasons for other chronic inflammatory conditions, such as Crohn's disease, ulcerative colitis, rheumatoid arthritis and artherosclerosis, the assembly said in its citation. Associated Press Quote Link to comment Share on other sites More sharing options...
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