RESEARCH - Increased cancer incidence in a Swedish cohort with SLE

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Scand J Rheumatol. 2002;31(2):66-71.

Increased cancer incidence in a Swedish cohort of patients with systemic

lupus erythematosus.

Bjornadal L, Lofstrom B, Yin L, Lundberg IE, Ekbom A.

Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden.

Lena.Bjornadal@...

OBJECTIVE: To assess the risk of cancer in patients with systemic lupus

erythematosus (SLE). METHODS: A population-based cohort of 5 715

hospitalised SLE patients was followed 1964-1995 through linkage of the

Hospital Discharge Register to the National Swedish Cancer Register.

RESULTS: In all, 443 malignancies occurred during the observation-period.

The overall risk was increased by 25% (SIR= 1.25, CI 95% 1.14-1.37) and

lymphomas constituted the major excess risk. The risk of non-Hodgkin's

lymphoma (NHL) was nearly 3-fold increased (SIR = 2.86, CI 95% 1.96-4.04).

There was also an increased risk of lung cancer (SIR= 1.73, CI 95%

1.25-2.32) and squamous cell skin cancer (SIR= 1.53, CI 95% 0.98-2.28),

which was most pronounced at more than 15 years of follow-up.

CONCLUSION:

The major finding was a bimodal incidence pattern with an increased risk of

lymphoma, mainly NHL, early during follow-up, but lung cancer and squamous

skin cancer later on.

PMID: 12109649

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

2109649 & dopt=Abstract

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