RESEARCH - Impact of parental history on patients' CV mortality in patients with RA

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Ann Rheum Dis. 2005 Oct 25; [Epub ahead of print]

Impact of parental history on patients' cardiovascular mortality in patients

with Rheumatoid Arthritis.

Bjornadal L, Brandt L, Klareskog L, Askling J.

Rheumatology Unit, Sweden.

BACKGROUND: Patients with Rheumatoid Arthritis (RA) are at increased risk of

death from cardiovascular disease (CVD). This risk is influenced by the

inflammatory activity of the RA-disease as well as by traditional risk

factors for CVD. Little is known, however, whether - or how much -

hereditary factors for CVD add additional risk for CVD in patients with RA.

METHODS: Population-based cohort study of 10,805 Swedish patients with RA

aged 16-67 years during follow- up (1990-2000). Parents, and cardiovascular

death among patients and parents, were identified through register-

linkages. Relative risk of death versus the general population was assessed

using standardised mortality ratios (SMR), which were compared using Poisson

regression. RESULTS: RA-patients with at parental history of fatal CVD had

an SMR of death from CVD of 2.9 (95%CI 2.5- 3.4). In contrast, RA-patients

without a parental history of fatal CVD had an SMR of 1.7 (95%CI 1.2-2.3). A

parental death from CVD was associated with a 70% increase in the risk of

fatal CVD in RA (SMR ratio = 1.7, 95% CI 1.2-2.4), and an increase in the

ten-year mortality from CVD from 5 to 10% in men and from 2 to 4% in women

aged 50-67 years.

CONCLUSIONS: Parental history of death from CVD is an important (and easily

assessable) risk factor for fatal CVD in RA.

PMID: 16249229

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6249229 & dopt=Abstract

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