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I know that has IBD or Crohn's.

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Yilmaz A, Yilmaz Demirci N, Hosgun D, Uner E, Erdogan Y, Gokcek A,

Caglar A.Pulmonary involvement in inflammatory bowel disease.

World J Gastroenterol 2010 October;16(39):4952-4957

Pulmonary involvement in inflammatory bowel disease

Yilmaz A, Yilmaz Demirci N, Hosgun D, Uner E, Erdogan Y, Gokcek A, Caglar

A.

Ataturk Chest Disease and Chest Surgery Training and Research Hospital,

Pulmonary Medicine, 06000 Ankara, Turkey. nilgundemirci@...

AIM: To determine the relationship of pulmonary abnormalities and bowel

disease activity in inflammatory bowel disease (IBD). METHODS: Thirty

ulcerative colitis (UC) and nine Crohn's disease patients, and 20 control

subjects

were enrolled in this prospective study. Detailed clinical information was

obtained. Extent and activity of the bowel disease were established

endoscopically. Each patient underwent pulmonary function tests and

high-resolution computed tomography (HRCT). Blood samples for measurement of

C-reactive

protein (CRP), erythrocyte sedimentation rate (ESR), angiotensin

converting enzyme and total IgE were delivered by the patients. RESULTS: Ten

(25.6%)

patients had respiratory symptoms. A pulmonary function abnormality was

present in 22 of 39 patients. Among all patients, the most prevalent

abnormalities in lung functions were a decrease in forced expiratory volume in

1 s

(FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF)

25%-75%, transfer coefficient for carbon monoxide (DLCO), DLCO/alveolar volume.

Increased respiratory symptoms score was associated with high endoscopic

activity index in UC patients. Endoscopic and clinical activities in UC

patients were correlated with FEV1, FEV1/FVC, and FEF 25%-75%. Smoking status,

duration of disease and medication were not correlated with pulmonary

physiological test results, HRCT abnormalities, clinical/endoscopic disease

activity, CRP, ESR or total IgE level or body mass index. CONCLUSION: It is

important that respiratory manifestations are recognized and treated early in

IBD. Otherwise, they can lead to destructive and irreversible changes in

the airway wall.