Re: Re: Vit D and infections/autoimmune diseases

[Guest guest]

Cramping can also occur with too much lactic acid (exercise induced usually)

and calcium overloads.

On Tue, Oct 5, 2010 at 8:18 PM, agirlnamedsuess21 <

agirlnamedsuess@...> wrote:

>

>

> We have a vitamin D deficiency in my family and we have been taking

> supplements, and still the lab tests are reading low (but higher than what

> they were). So, my son and I (the ones with deficiency diagnosed) began

> getting cramps in our feet and toes (really bad and deforming cramps) about

> 20 minutes after we supplemented with Vitamin D. So, now I am wondering if

> our body has a deficiency simply to ward off muscles cramps (caused by ??

> unknown)?

> I know cramps can be a side effect of too much, but our levels are still

> below normal.

>

>

> >

> >

> > <<inadequate vitamin D levels to a higher susceptibility of

> > immune-mediated disorders, including chronic infections and autoimmune

> diseases.>>

> >

> >

> > _Curr Opin Pharmacol._ (javascript:AL_get(this, 'jour', 'Curr Opin

> > Pharmacol.') 2010 Aug;10(4):482-96. Epub 2010 Apr 27.

> > Vitamin D: modulator of the immune system.

> > _Baeke F_ (http://www.ncbi.nlm.nih.gov/pubmed?term= " Baeke%20F " [Author])

> ,

> > _Takiishi T_

(http://www.ncbi.nlm.nih.gov/pubmed?term= " Takiishi%20T " [Author])

>

> > , _Korf H_ (http://www.ncbi.nlm.nih.gov/pubmed?term= " Korf%20H " [Author])

> ,

> > _Gysemans C_

(http://www.ncbi.nlm.nih.gov/pubmed?term= " Gysemans%20C " [Author])

>

> > , _Mathieu C_

> > (http://www.ncbi.nlm.nih.gov/pubmed?term= " Mathieu%20C " [Author]) .

> > Laboratory of Experimental Medicine and Endocrinology (LEGENDO),

> > Katholieke Universiteit Leuven. 3000 Leuven, Belgium.

> >

> > Abstract

> > 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin

> D,

> > is known to regulate calcium and phosphorus metabolism, thus being a

> > key-player in bone-formation. However 1,25(OH)(2)D(3) also has a

> physiological

> > role beyond its well-known role in skeletal homeostasis. Here, we

> describe

> > 1,25(OH)(2)D(3) as an immunomodulator targeting various immune cells,

> > including monocytes, macrophages, dendritic cells (DCs), as well as

> T-lymphocytes

> > and B-lymphocytes, hence modulating both innate and adaptive immune

> > responses. Besides being targets, immune cells express vitamin

> D-activating

> > enzymes, allowing local conversion of inactive vitamin D into

> 1,25(OH)(2)D(3)

> > within the immune system. Taken together, these data indicate that

> > 1,25(OH)(2)D(3) plays a role in maintenance of immune homeostasis.

> Several

> > epidemiological studies have linked inadequate vitamin D levels to a

> higher

> > susceptibility of immune-mediated disorders, including chronic infections

> and

> > autoimmune diseases. This review will discuss the complex

> immune-regulatory

> > effects of 1,25(OH)(2)D(3) on immune cells as well as its role in

> infectious and

> > autoimmune diseases, more in particular in tuberculosis and type 1

> > diabetes (T1D).

> > PMID: 20427238 [PubMed - in process]

> >

> >

> >