INFO - Folic acid on MTX day

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Methotrexate

By Alan K. Matsumoto, M.D. (31-Aug-2005)

Question:

I take 12.5mg of methotrexate per week for rheumatoid arthritis. I

also take 1mg of folic acid every day except on the day I take the

methotrexate and the day after. In the fall I also take a multi vitamin

which contains 0.4mg of folic acid. Is that to much folic acid to take and

can it cause the methotrexate not to work as well? Should I also not take it

on the day of the methotrexate and the day after?

Answer:

Folic acid supplementation should not effect MTX. I do not ask

patients to stop Folic acid on the days they take MTX, although some

rheumatologists do. I frequently increase folic acid above 1 mg per day to

reduce side effects such as mouth ulcers.

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