Re: Fwd: Unprovoked Seizures in Autistic Individuals by Tapan Aud...

[Guest guest]

Irma:

Can't get the link to work - are you able to send the text in an email?

Thanks!

Heidi

[Guest guest]

Hi Heidi,

There is a video clip of the powerpoint presentation.

http://www.autismone.org/content/unprovoked-seizures-autistic-individuals-tapan-\

audhya-phd

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Evidence of both clinical and subclinical seizures has been reported in

children with autism spectrum disorder (ASD). Approximately 20-30% of

autistic children have a seizures disorder. Of course, this estimate does

not include children who initiate seizures when proved by frustration, fear,

sudden shock, high fever, anger, or exposed to high pressure oxygen chamber.

In our experience, many ASD children with untreated PKU, cerebral palsy,

neuroinflammation, or mental retardation have a higher risk of seizures;

also, children who display sudden repetitive movements, swaying, language

regression (particularly after 2-4 years of age), etc., often have

experienced seizures. On the other hand, many seizure-free autistic

individuals begin to have seizures during puberty. Many autism candidate

genes that have been associated with autism risk encode for proteins that

regulate excitation/inhibition within CNS. These include nicotinic

acetylcholine receptors, GABA receptors, glutamate receptors, etc. An

altered GABA-A receptor, found very often in autistic individuals, has been

proposed as a major underlying cause of seizures. Because GABA inhibits

neurons from firing, and seizures are caused by inappropriate or unregulated

firing of nerve cells, increasing or decreasing GABA activity through its

receptors can cause the system to stabilize or destabilize and thus control

seizures. In the presentation we will discuss some of the information that

we have developed in our laboratory regarding seizures in autistic

individuals.

*If the link above does not work, wondering if you could click this link

then cut & paste the subject title: http://www.autismone.org/

on the search box.

Unprovoked Seizures in Autistic Individuals by Tapan Audhya, PhD

I wonder if you also have to join to view anything.

*

Irma

>

>

> Irma:

>

> Can't get the link to work - are you able to send the text in an email?

>

> Thanks!

>

> Heidi

>

>