language development and age of diagnosis of autism

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Interesting abstract of the day...

Social and Communication Development in Toddlers With Early and Later Diagnosis

of Autism Spectrum Disorders

J. Landa, PhD;

C. Holman, PhD;

Garrett-Mayer, PhD

Arch Gen Psychiatry. 2007;64:853-864.

Context To our knowledge, no prospective studies of the developmental course of

early and later diagnosis of autism spectrum disorders from 14 months of age

exist.

Objective To examine patterns of development from 14 to 24 months in children

with early and later diagnosis of autism spectrum disorders.

Design Prospective, longitudinal design in which 125 infants at high and low

risk for autism were tested from age 14 to 36 months. Comprehensive standardized

assessments included measures of social, communication, and play behavior.

Setting Testing occurred at a major medical and research institution as part of

a large, ongoing longitudinal study.

Participants Low-risk controls (n = 18) and siblings of children with autism,

grouped on the basis of outcome diagnostic classification at 30 or 36 months:

autism spectrum disorders (early diagnosis, n = 16; later diagnosis, n = 14),

broader autism phenotype (n = 19), and non–broader autism phenotype (n = 58).

Main Outcome Measures Social, communication, and symbolic abilities were

assessed.

Results Social, communication, and play behavior in the early-diagnosis group

differed from that in all other groups by 14 months of age. By 24 months, the

later-diagnosis group differed from the non–autism spectrum disorder groups in

social and communication behavior, but not from the early-diagnosis group.

Examination of growth trajectories suggests that autism may involve

developmental arrest, slowing, or even regression.

Conclusion This study provides insight into different patterns of development

of children with early vs later diagnosis of autism spectrum disorders.

Author Affiliations: Kennedy Krieger Institute, Center for

Autism and Related Disorders, The s Hopkins School of Medicine (Drs

Landa and Holman), and Division of Biostatistics, Sidney Kimmel

Comprehensive Cancer Center, The s Hopkins University (Dr

Garrett-Mayer), Baltimore, land.

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