[CoMeD] Drft 1-pager_Non-HgPreservatives

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ALL,

Attached are the " doc " and " pdf " files for a one-pafger

that discuss the replacement of Thimerosal (49.55% mercury

by weight) with non-mercury alternatives.

For those who do not receive attachments, the " .pdf "

version of this article can be found in bothe the

" Documents " section of the CoMeD web site:

http://www.Mercury-freeDrugs.org by the mid-January

2011 at the latest.

In addition, the rough text of the article (without

the footnotes) follows:

>

>

> The Viability of Using Non-mercury Preservatives in

> Vaccines, Prepared by the Coalition for Mercury-Free

> Drugs (CoMeD), Inc., 2010 ©

>

>At question: The use of Thimerosal, a recognized human

>carcinogen, mutagen, teratogen, reproductive toxin,

>and immune-system disruptor that is 49.55% by weight

>bioaccumulative mercury, in vaccines.

>

>Eli Lilly Thimerosal MSDS Warning: " Exposure to mercury

> in utero and in children may cause mild to severe

> mental retardation and mild to severe motor

> coordination impairment. "

>

>Summary:

> v Use of Thimerosal as a preservative in biologics is

> both historic and indefensible, in terms of 21st

> Century science, medicine, law and ethics.

> v In 1999, The U.S. Public Health Service and the

> American Academy of Pediatrics jointly called for

> Thimerosal to be removed from vaccines as soon as

> possible.

> v The prudent and ethical transition to a safer and

> more effective preservative is encountering massive

> resistance from industry and health agencies.

> v Issues of damage and liability are preventing

> institutions, which perpetuate the use of Thimerosal,

> from objectively judging this public health issue.

> v As lead was eliminated from paint and gasoline, so

> too will mercury compounds, which are 10 to 100 times

> more toxic than their lead analogs, be banned from

> vaccines and other drugs only after they have already

> damaged generations of children.

>

>The Alternatives

>

>Based on a survey of U.S.-FDA-approved preserved vaccines,

>other viable alternatives to Thimerosal as a preservative

>in commercial vaccines packaged in multidose vials are:

> § phenol [used in the Typhoid Vi Polysaccharide (Typhim

> Vi; Sanofi Pasteur, SA) and the Pneumococcal Polysac-

> charide (Pneumovax 23; Merck & Co, Inc) vaccines], and

> § 2-phenoxyethanol [used in the DTaP (Infanrix®; GSK),

> Hepatitis A (Havrix ®; GSK), Hepatitis A/Hepatitis B

> (Twinrix ®; GSK) and IPV (IPOL®; Sanofi Pasteur, SA)

> vaccines]

>

>Relative Toxicities

>

>In decreasing order, the relative toxicities (human cell to

>bacterial cell) of the following compounds are:

> Thimerosal (> 330-fold) >> Phenol (12.2-fold) > 2-phenoxy-

> ethanol (4.6-fold).

>

>With respect to the least toxic compound, 2-phenoxy ethanol

>(2-PE):

> · Vaccine makers have already replaced Thimerosal with

> 2-PE in many vaccines,

> · 2-PE is more than 100-fold safer to use at vaccine

> preservative levels (2.5%) than Thimerosal (0.01%),

> and

> · 2-PE is not converted into a bioaccumulative toxin

> (tissue-bound inorganic mercury) like Thimerosal is.

>

>Progress in vaccine safety demands rapid movement to less

>toxic preservatives if public confidence in the vaccine

>program is to be preserved.

>

>The 2-phenoxyethanol (2-PE) Alternative to Thimerosal is

>Economical

>

>The U.S.-$-per-0.5-mL-dose cost for:

> · Thimerosal, USP, in a 0.01% Thimerosal-preserved

> vaccine is about: U.S. $ 0.000441;

> · 2-phenoxyethanol, Ph Eur, in a 2.5% 2-phenoxyethanol-

> preserved vaccine is: U.S. $ 0.00228.

>

>This apparent U.S. $ 0.001839 increased cost per dose

>would be offset by:

> · The reduced costs associated with its handling,

> and

> · The 2+% reduction in the amount of water-for-

> injection needed per dose.

>

>Thus, the reduction in the hazard would offset the

>minor increase in the per-dose cost for using 2-PE.

>

>Elimination of the Use of Thimerosal:

>

> " We agree that we do not need to have thimerosal in

> vaccines. If it doesn't need to be there, we should

> take it out. And we should take it out as rapidly as

> possible. We have agreed to that. The Public Health

> Service, the vaccine manufacturers, and the academies

> are all in agreement … "

> (Dr. Bernier, Chief Science Advisor to the CDC,

> " Mercury in Medicine-Are We Taking Unnecessary Risks? " -

> Sworn Testimony to the Government Reform Committee,

> July 18, 2000, Serial No. 106-232)

>

> " Resolved: The United Methodist Church support all

> efforts to protect the public, especially children,

> from mercury-containing drugs by calling on the World

> Health Organization, international and national health

> officials/agencies to: …ban the presence of any mercury

> compound in pharmaceutical products or vaccines, pre-

> scribed or over-the-counter. "

> (The Book of Resolutions of the United Methodist Church,

> 2008, pp. 372-377)

>

>Industry Concerns Regarding the Use of Thimerosal:

>

> " In other words, Merthiolate [i.e, Thimerosal] is un-

> satisfactory as a preservative for serum intended for

> use on dogs… we have tested Merthiolate on humans and

> find that it gave a more marked…reaction than does

> phenol or tricresol. "

> (July 22, 1935, the Pitman- Company in a letter

> to Eli Lilly and Company)

>

> " The ethical justification for continued use of

> Thimerosal-preserved multidose vials in developing

> countries would be based on the greater importance

> of disease prevention than the real hazard from

> giving small amounts of mercury preservative… "

> (Merck's Vaccine Task Force Report, " Thimerosal

> (Merthiolate) Preservative - Problems, Analysis,

> Suggestions for Resolution " , 1991)

>

> " Conclusions...Thimerosal is not an effective preser-

> vative compared to 2-PE [i.e., 2-phenoxyethanol] ...

> The data support the use of 2-PE as a more effective

> preservative with the potential to replace thimerosal,

> the most commonly used preservative in multi-dose

> vaccine formulations. "

> ( " Development of a Multi-Dose Formulation of Prevenar

> 13 " Lakshmi Khandke, et al., supported by the World

> Health Organization, GAVI Alliance, UNICEF, the Bill

> & Melinda Gates Foundation, and Pfizer)

>

>US Government Concerns Regarding the Use of Thimerosal

>(non-health agencies):

>

> " ...the Committee, upon a thorough review of the scien-

> tific literature and internal documents from government

> and industry, did find evidence that Thimerosal did pose

> a risk...Our public health agencies' failure to act is

> indicative of institutional malfeasance for self-protec-

> tion and misplaced protectionism of the pharmaceutical

> industry. "

> ( " Mercury in Medicine-Are We Taking Unnecessary Risks? "

> Government Reform Committee, May 2003)

>

> " …based on the publicly available information…it appears

> there may be sufficient evidence to find a substantial

> likelihood of a substantial and specific danger to

> public health caused by the use of thimerosal/mercury

> in vaccines because of its inherent toxicity. "

> (US Special Counsel Bloch, Letter to Congress,

> May 20, 2004)

>

>

Please share this message with others who seek

to understand that the use of Thimerosal, an

exquisite mercury posion for mammals including

humans, as a preservative in vaccines is totally

unnecessary.

Thanking everyone in advance for all of your efforts,

no matter how small, to spread this document to the

four corners of the Earth. this reviewer remains ...

Respectfully,

G. King, PhD

http://www.dr-king.com

CoMeD Science Advisor

PS: My apologies if you get more than one email as,

for this email, several lists have been merged

but all the duplicates may not have been removed.

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