** Article Metabolic syndrome / Fibromyalgia

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Metabolism. 2007 Jan

Metabolic syndrome in women with chronic pain.

Loevinger BL, Muller D, Alonso C, Coe CL

Center for Women's Health Research,

University of Wisconsin School of Medicine and Public Health,

Madison, WI 53715, USA.

Fibromyalgia is a prevalent syndrome characterized by chronic pain, fatigue, and

insomnia.

Patients with fibromyalgia commonly have an elevated body mass index and are

physically inactive, 2 major risk factors for metabolic syndrome.

Yet little is known about the relationship between chronic pain conditions and

metabolic disturbances.

Our study evaluated the risk for, and neuroendocrine correlates of, metabolic

syndrome in this patient population. Women with fibromyalgia (n = 109) were

compared with control healthy women (n = 46), all recruited from the community.

Metabolic syndrome was identified by using criteria from the Adult Treatment

Panel III with glycosylated hemoglobin concentrations substituted for serum

glucose.

Catecholamine and cortisol levels were determined from 12-hour overnight urine

collections.

Women with fibromyalgia were 5.56 times more likely than healthy controls to

have metabolic syndrome (95% confidence interval, 1.25-24.74).

Fibromyalgia was associated with larger waist circumference (P = .04), higher

glycosylated hemoglobin (P = .01) and serum triglyceride (P < .001) levels, and

higher systolic (P = .003) and diastolic (P = .002) blood pressure.

Total and low-density lipoprotein cholesterol were also significantly higher in

women with fibromyalgia (P = .001 and .02, respectively), although high-density

lipoprotein cholesterol was in the reference range.

These associations were not accounted for by age or body mass index. Meeting

criteria for more metabolic syndrome components was related to higher urinary

norepinephrine (NE)/epinephrine and NE/cortisol ratios (P < .001 and P = .009,

respectively).

Women with chronic pain from fibromyalgia are at an increased risk for metabolic

syndrome, which may be associated with relatively elevated NE levels in

conjunction with relatively reduced epinephrine and cortisol secretion.

F I B R O M Y A L

G I A

Pain, can't fall asleep or can't stay asleep, brain fog, depression,

procrastination,

obsessive-compulsive disorder, chemically sensitive, light sensitive, extreme

fatigue,

irritable gut, thinning hair, headaches, TMJ, skin problems, swelling, acid

reflux?

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