Ca: Governor orders moth spray ingredients released - CheckMate LBAM-F

[Guest guest]

Although the news article is about Calif and its soon-to-occur spraying,

there are general principles herein. Inter-individual variance for detox

capability is quite large; bureaucrats generally favor intoxination by not

considering inter-individual variance.

This email has several parts.

1, a summary of the variance findings.

2, the list of ingredients to be sprayed.

3, the news article.

4, the abstract of the variance study.

- - - -

Although a recent study focused upon human reactions to ogranophosphates,

the findings of inter-individual variance are relevant for many toxins.

What may be " safe " for most people can be be injurious to some people.

Pharmacogenetics & Genomics. 5 March 2006:

A study of Latina women and their children found unexpectedly high

variation in vulnerability to organophosphate pesticide impacts. Some

newborns were 26 to 50 times more susceptible than others, and 65 to 130

times more sensitive than some adults. The results indicate

current standards may not be sufficiently protective.

[Abstract follows news item]

- - - -

*CheckMate LBAM-F ingredients*

* Water

* (E)-11-Tetradecen-1-yl Acetate

* (E,E) -9,11 Tetradecadien-1-yl Acetate

* Crosslinked polyurea polymer

* Butylated Hydroxytoluene

* Polyvinyl Alcohol

* Tricaprylyl Methyl Ammonium Chloride

* Sodium Phosphate

* Ammonium Phosphate

* 1,2-benzisothiozoli-3-one

* 2-hydroxy-4-n-octyloxybenzophenone

- - - -

October 21, 2007

Governor orders moth spray ingredients released

By TOM RAGAN and julie copeland

SENTINEL STAFF WRITERs

http://www.santacruzsentinel.com/archive/2007/October/21/local/stories/01local.h\

tm

[Hearing schedule hereinbelow]

SACRAMENTO — Gov. Arnold Schwarzenegger ordered the California Department

of Food and Agriculture on Saturday to release the list of ingredients in

the pheromone that will be sprayed on Santa Cruz and Monterey counties to

eradicate the light brown apple moth.

The governor's decision follows a judge's ruling Friday to lift a

temporary restraining order that will allow the state to resume spraying.

Previously, the Oregon company that manufactures CheckMate — the pheromone

that will be used on the moth — said the ingredients were trade secrets,

covered by state and federal law.

The governor made it clear Saturday he supports the eradication program

and thinks the product's ingredients should be disclosed " to the maximum

extent possible under U.S. trademark law, " A.G. Kawamura, the state's Food

and Agriculture secretary, said in a statement accompanying the governor's

announcement.

" The governor supports the public's right to know every ingredient in the

product and is confident that full disclosure will confirm what my

department, the California Environmental Protection Agency and California

Department of Pesticide Regulation established before treatment began —

that CheckMate LBAM-F is nontoxic to humans, plants, animals and insects "

Friday, Monterey County Superior Court Judge A. O'Farrell lifted a

court-ordered ban instituted Oct. 10 on the state's aerial spraying. The

judge ruled that Helping Our Peninsula's Environment, a Carmel

environmental group, failed to prove that one of the Suterra's pesticides,

CheckMate OLR-F, was responsible for sickening more than 100 people on the

Monterey Peninsula in late September after the state sprayed 60 acres

there.

The judge said he imposed the ban because he initially thought CheckMate

OLR-F contained a potentially harmful chemical. The CheckMate ingredients

were mistakenly provided to the Sentinel in late September by the EPA,

which set in motion a series of lawsuit filings by Suterra to protect

their secrecy. Suterra sued the Sentinel and the Monterey County Weekly

for publishing those ingredients. The suit was dropped Friday. The EPA

later said the chemical was a starter compound, not found in the final

composition.

HOPE claimed CheckMate OLR-F was making people sick, including wheezing,

coughing, sore throats and asthma. Dilworth, executive director of

HOPE, did not return calls seeking comment Saturday but has said his group

will not immediately appeal the judge's decision to lift the ban.

Advertisement

Santa Cruz City Councilman Ed Porter called the governor's move " pretty

cool, but I don't know if I'm in favor of spraying, though. I think time

should be taken and an analysis should be done, but we've only got two

weeks and it's a lot of chemistry we have to look at, and it's going to be

complicated. ... I would hope that the governor would postpone the

spraying project "

-Ann Warmerdam, director of Cal-EPA's Department of Pesticide

Regulation, said " California has what is considered the strictest and most

comprehensive state pesticide regulatory program in the nation. My

department will continue to assist the LBAM task force [established in

Thursday's court hearing] in performing further analysis and monitoring to

ensure that the community's concerns are fully considered "

The Public Health Science Task Force, consisting of scientists from the

departments of the California EPA, including the state Department of

Pesticide Regulation and state Department of Public Health, will review

all health- and environmental-related issues surrounding the use of

CheckMate.

CheckMate OLR-F will not be sprayed on the peninsula again. Instead the

state will use CheckMate LBAM-F. That's the formula the governor ordered

released Saturday and what will be sprayed over parts of both Santa Cruz

and Monterey counties this month and next. The pesticides are similar,

though the pheromones — think of them as perfumes — are different. The

pheromone in CheckMate LBAM-F is BHT [butylated hydroxytoluene], a common

food additive found in things like cereal.

The active ingredients of the pesticide are mostly water-based pheromones,

which replicate the scent of a female. The pheromones, which will be

sprayed from planes 500 to 800 feet overhead, confuse the male moths,

disrupting the mating process.

In the face of some public dissent, the state says the moth infestation is

an emergency that must be stopped soon to spare California's agriculture

economy. The moth, native to Australia, is capable of causing up to $640

million in damages to crops a year if left unchecked, the state says.

The highest known concentration of the light brown apple moth in the state

is in Live Oak and Soquel, with more than 7,500 trapped. The state says

the moth has the potential to damage 250 crops and more than 1,000 plants

including the Central Coast cypress, redwoods, oaks and other varieties

found in urban and suburban landscaping, public parks and the natural

environment. Among the list of agricultural crops on the moth's diet are

grapes, citrus and stone fruits. The pest damages plants and crops by

feeding on leaves, new shoots and fruit.

Aerial treatment on the Monterey Peninsula is set to resume Wednesday and

continue through Saturday. Spraying in North Monterey and parts of Santa

Cruz County is slated to take place Nov. 4-9.

As part of the judge's ruling Thursday, the state agreed to establish

public outreach and response programs including:

* A Web site with information about the moth, which can be found at

www.cdfa.ca.gov/LBAM.

* An e-mail subscription service — under development — with real-time

information.

* An e-mail and phone hot line to log health complaints to be

monitored daily: LBAM@..., [800] 491-1899, ext. 0. The hot line

will log health complaints, which will be compiled and analyzed by a

medical toxicologist. Complaints could be forwarded to the local county

agricultural commissioner for investigation or the county

public health officer.

* Fact sheets addressing health and science issues are being developed

for distribution and posting on the Web site.

* Community meetings have been set and mailers sent to all homes in

the affected communities.

* Aerial treatment maps will be posted on the Web site showing the

previous night's spray path. The maps will present a schematic showing

each 100-foot wide path the planes make. Each pass will receive a

single spray of treatment; nozzles are turned on and off using a

computerized system guided by GPS technology.

The ag department has arranged to send e-mail updates to subscribers

announcing intended areas of treatment, weather permitting. The morning

after the treatment, follow-up e-mails will be sent to subscribers with

results of the applications. E-mails will include a link to a map showing

the progress of the treatment. Those interested in receiving e-mail

updates may sign up at:

http://www.cdfa.ca.gov/phpps/PDEP/lbam/lbam_main.html

Contact Tom Ragan at tragan@... and Copeland at

jcopeland@....

Light brown apple moth public hearings

Oct. 22

Cocoanut Grove Grand Ballroom, 400 Beach St., Santa Cruz.

5-7 p.m.: Open house.

7-8 p.m.: Presentation.

8-10 p.m.: Public comment.

Oct. 23

University Inn and Conference Center, 611 Ocean St., Santa Cruz.

4:30-7:30 p.m.: Open house.

7:30-8:30 p.m.: Presentation.

8:30-11 p.m.: Public comment.

Former state Assembly member and current Santa Cruz County Treasurer Fred

Keeley will serve as moderator.

CheckMate LBAM-F ingredients

* Water

* (E)-11-Tetradecen-1-yl Acetate

* (E,E) -9,11 Tetradecadien-1-yl Acetate

* Crosslinked polyurea polymer

* Butylated Hydroxytoluene

* Polyvinyl Alcohol

* Tricaprylyl Methyl Ammonium Chloride

* Sodium Phosphate

* Ammonium Phosphate

* 1,2-benzisothiozoli-3-one

* 2-hydroxy-4-n-octyloxybenzophenone

SOURCE: California Department of Agriculture

- - - -

1: Pharmacogenet Genomics. 2006 Mar;16(3):183-90.

PON1 status of farmworker mothers and children as a predictor of

organophosphate sensitivity.

Furlong CE, Holland N, Richter RJ, Bradman A, Ho A, Eskenazi B.

Department of Genome Sciences, Division of Medical Genetics, University of

Washington, Seattle, Washington 98195-7720, USA. clem@...

The objective was to determine PON1 status as a predictor for

organophosphorus insecticide sensitivity in a cohort of Latina mothers and

newborns from the Salinas Valley, California, an area with high levels of

organophosphorus insecticide use. PON1 status was

established for 130 pregnant Latina women and their newborns using a

high-throughput two substrate activity/analysis method which plots rates

of diazoxon (DZO) hydrolysis against rates of paraoxon (PO)

hydrolysis. Arylesterase activity (AREase) was determined using

phenylacetate as a substrate, allowing comparison of PON1 levels

across PON1192 genotypes in mothers and children. Phenylacetate

hydrolysis is not affected by the Q192R polymorphism. Among newborns,

levels of PON1 (AREase) varied by 26-fold (4.3-110.7 U/ml) and among

mothers by 14-fold (19.8-281.4 U/ml). On average, children's PON1

levels were four-fold lower than the mothers' PON1 levels (P<0.001).

Average PON1 levels in newborns were comparable with reported hPON1 levels

in transgenic mice expressing human PON1Q192 or PON1R192,

allowing for prediction of relative sensitivity to chlorpyrifos oxon (CPO)

and DZO. The predicted range of variability in sensitivity of mothers and

children in the same Latino cohort was 65-fold for DZO and 131 to 164-fold

for CPO. Overall, these findings indicate that many of the newborns and

some of the mothers in this cohort would be more

susceptible to the adverse effects of specific organophosphorus

pesticide exposure due to their PON1 status. Of particular concern are

exposures of pregnant mothers and newborns with low PON1 status.

Publication Types:

* Research Support, N.I.H., Extramural

* Research Support, U.S. Gov't, Non-P.H.S.

PMID: 16495777

*

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