Alzheimer: Dietary patterns and risk of dementia: the Three-City cohort study

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For parents and physicians who work with autistic children, finding

support for nutrients is important. Here's one such peer-reviewed article:

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Neurology. 2007 Nov 13;69(20):1921-30.*

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*Dietary patterns and risk of dementia: the Three-City cohort study.*

Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C,

Dartigues JF, Alpérovitch A.

INSERM, U593, University Victor Segalen Bordeaux 2, case 11, 146 rue

Léo-Saignat, F-33076 Bordeaux cedex, France.

Pascale.Barberger-Gateau@...

BACKGROUND: Dietary fatty acids and antioxidants may contribute to

decrease dementia risk, but epidemiologic data remain controversial. The

aim of our study was to analyze the relationship between dietary

patterns and risk of dementia or Alzheimer disease (AD), adjusting for

sociodemographic and vascular risk factors, and taking into account the

ApoE genotype. METHODS: A total of 8,085 nondemented participants aged

65 and over were included in the Three-City cohort study in Bordeaux,

Dijon, and Montpellier (France) in 1999-2000 and had at least one

re-examination over 4 years (rate of follow-up 89.1%). An independent

committee of neurologists validated 281 incident cases of dementia

(including 183 AD). RESULTS: Daily consumption of fruits and vegetables

was associated with a decreased risk of all cause dementia (hazard ratio

---

0.72, 95% CI 0.53 to 0.97) in fully adjusted models. Weekly

consumption of fish was associated with a reduced risk of AD (HR 0.65,

95% CI 0.43 to 0.994) and all cause dementia but only among ApoE epsilon

4 noncarriers (HR 0.60, 95% CI 0.40 to 0.90). Regular use of omega-3

rich oils was associated with a decreased risk of borderline

significance for all cause dementia (HR 0.46, 95% CI 0.19 to 1.11).

Regular consumption of omega-6 rich oils not compensated by consumption

of omega-3 rich oils or fish was associated with an increased risk of

dementia (HR 2.12, 95% CI 1.30 to 3.46) among ApoE epsilon 4

noncarriers. CONCLUSION: Frequent consumption of fruits and vegetables,

fish, and omega-3 rich oils may decrease the risk of dementia and

Alzheimer disease, especially among ApoE epsilon 4 noncarriers.

Publication Types:

* Comparative Study

* Research Support, Non-U.S. Gov't

PMID: 17998483