Re: Moducare & TH1/TH2

[Guest guest]

There is a short note on Moducare by the manufacturer:

http://www.moducarepractitioner.co.uk/2_minute_explanation.htm

It's said to balance TH1 and TH2, and particularly to restore the TH1

skew. I have used it a lot for many months, especially during the

times I used Yasko metals RNAs. I cannot quantify how good Moducare

has been doing to balance the immune and autoimmune.

At the risk of changing the topic, I'm interested in knowing how to

determine whether one is TH1 skewed or TH2 skewed. According to my DAN

doctor, one can be overactive in both TH1 and Th2. For example, my

child does not get sick, no asthma or allergy, but at the same time, I

believe that she has an extraordinary viral/bacteria/metals load,

which which indicates cellular immune system (ie. TH2)is

malfucntioiung. Is she TH1 skewed or Th2 skewed? what lab tests would

indicate?

I'd much appreciate if anyone would shed light on this issue that I

find perplexing.

Thank you for your help,

Bo

[Guest guest]

Dear Listmates,

Have you used subclasses of IgG to determine Th1 or Th2 dominance? The

following articles suggest the use of IgG subclass:

Thank you,

Bo

http://www.jci.org/cgi/content/abstract/97/7/1597

J. Clin. Invest.

Volume 97, Number 7, April 1996, 1597-1604

Imbalance Towards Th1 Predominance Is Associated with

Acceleration of Lupus-like Autoimmune Syndrome in MRL Mice

Satoru Takahashi*, Liliane Fossati*,

Masahiro Iwamoto*, Ramón Merino*, Roland Motta,

Takatoshi Kobayakawa§, and Shozo Izui*

* Department of Pathology, Centre Médical Universitaire,

University of Geneva, 1211 Geneva 4, Switzerland; Institut

Transgenose, 45071 Orléans, France; and § Department of

International Affairs and Tropical Medicine, Tokyo Women's Medical

College, Tokyo 162, Japan

To investigate the respective roles of Th1 and Th2 cells in the

pathogenesis of lupus-like autoimmune disease, we have analyzed

the spontaneous and antigen-induced productions of IgG1 vs

IgG2a and IgG3 subclasses in relation to the mRNA expression

of INF- (Th1 cytokine promoting IgG2a and IgG3 production),

IL-4 (Th2 cytokine promoting IgG1 production), and IL-10 (Th2

cytokine) in CD4+ T cells from lupus-prone MRL

mice. For this purpose, two paired sets of MRL mice were

chosen for the comparison of these parameters: (a)

MRL-lpr/lpr (lpr for lymphoproliferation) and its

recently described substrain with a prolonged survival, termed

MRL-lpr/lpr.ll (ll for long lived) and

( MRL male mice bearing the Yaa (Y-linked

autoimmune acceleration) gene (MRL.Yaa) with an accelerated

disease and their male counterparts lacking the Yaa

gene. We demonstrate herein that the accelerated development

of lupus-like autoimmune disease in MRL-lpr/lpr and

MRL.Yaa mice, as compared with MRL-lpr/lpr.ll

and MRL-+/+ mice, respectively, was correlated with an

enhanced expression of IFN- vs IL-4 and IL-10 mRNA in

CD4+ T cells, which paralleled with an increase of spontaneous

and foreign T cell-dependent antigen-induced productions of

IgG2a and IgG3 vs IgG1 antibodies. These data suggest that an

imbalance towards Th1 predominance may play a significant role

in the acceleration of lupus-like autoimmune disease in MRL

mice. (J. Clin. Invest. 1996. 97:1597-1604.)

>

> There is a short note on Moducare by the manufacturer:

> http://www.moducarepractitioner.co.uk/2_minute_explanation.htm

>

> It's said to balance TH1 and TH2, and particularly to restore the TH1

> skew. I have used it a lot for many months, especially during the

> times I used Yasko metals RNAs. I cannot quantify how good Moducare

> has been doing to balance the immune and autoimmune.

>

> At the risk of changing the topic, I'm interested in knowing how to

> determine whether one is TH1 skewed or TH2 skewed. According to my DAN

> doctor, one can be overactive in both TH1 and Th2. For example, my

> child does not get sick, no asthma or allergy, but at the same time, I

> believe that she has an extraordinary viral/bacteria/metals load,

> which which indicates cellular immune system (ie. TH2)is

> malfucntioiung. Is she TH1 skewed or Th2 skewed? what lab tests would

> indicate?

>

> I'd much appreciate if anyone would shed light on this issue that I

> find perplexing.

>

> Thank you for your help,

> Bo

>

[Guest guest]

Hi Bo -

I came across this and thought that you would find it helpful. Have to paste

the whole link in.

http://www.cureautismnow.org/site/apps/nl/content2.asp?c=bhLOK2PILuF & b=1289185 & c\

t=2505379 & tr=y & auid=1700278

Trisha

bmacinni wrote:

There is a short note on Moducare by the manufacturer:

http://www.moducarepractitioner.co.uk/2_minute_explanation.htm

It's said to balance TH1 and TH2, and particularly to restore the TH1

skew. I have used it a lot for many months, especially during the

times I used Yasko metals RNAs. I cannot quantify how good Moducare

has been doing to balance the immune and autoimmune.

At the risk of changing the topic, I'm interested in knowing how to

determine whether one is TH1 skewed or TH2 skewed. According to my DAN

doctor, one can be overactive in both TH1 and Th2. For example, my

child does not get sick, no asthma or allergy, but at the same time, I

believe that she has an extraordinary viral/bacteria/metals load,

which which indicates cellular immune system (ie. TH2)is

malfucntioiung. Is she TH1 skewed or Th2 skewed? what lab tests would

indicate?

I'd much appreciate if anyone would shed light on this issue that I

find perplexing.

Thank you for your help,

Bo

Many frequently asked questions and answers can be found at