bisphenol-A and behavior

[Guest guest]

The pubmed search

bisphenol-A AND (behavior[ti] OR behaviour[ti] OR cognitive[ti] OR

cognition[ti] OR hyperactiv*[ti])

is restricted to title words via [ti] and nonetheless generated 55

citations. Appx 160 citations w/o the restriction.

The citations suggest that bisphenol-A (BPA) alters various aspects of

behavior. Ought we say that " bisphenol-A " causes autism? Probably not.

Ought we suspect that bisphenol-A is contributing nuances to the range of

traits known as the ASDs? Probably so.

As this morning's previous BPA post indicated, BPA affects at least some

detox pathways. Thus, intra-body BPA also seems likely to increase the

likelihood of adverse effects from other toxins - whether deliberately

injected or obtained by other routes.

A sampling of BPA-effects citations follows. Some are free online, links

by redoing the search presented hereinabove.

1: Xu X, Liu Y, Sadamatsu M, Tsutsumi S, Akaike M, Ushijima H, Kato N.

Perinatal bisphenol A affects the behavior and SRC-1 expression of male

pups but does not influence on the thyroid hormone receptors and its

responsive gene.

Neurosci Res. 2007 Feb 23; [Epub ahead of print]

PMID: 17412439 [PubMed - as supplied by publisher]

2: vom Saal FS.

Bisphenol A eliminates brain and behavior sex dimorphisms in mice: how

low can you go?

Endocrinology. 2006 Aug;147(8):3679-80. No abstract available.

PMID: 16847092 [PubMed - indexed for MEDLINE]

3: Della Seta D, Minder I, Belloni V, Aloisi AM, Dessi-Fulgheri F,

Farabollini

F.

Pubertal exposure to estrogenic chemicals affects behavior in juvenile and

adult male rats.

Horm Behav. 2006 Aug;50(2):301-7. Epub 2006 May 22.

PMID: 16716326 [PubMed - indexed for MEDLINE]

4: Fujimoto T, Kubo K, Aou S.

Prenatal exposure to bisphenol A impairs sexual differentiation of

exploratory behavior and increases depression-like behavior in rats.

Brain Res. 2006 Jan 12;1068(1):49-55. Epub 2005 Dec 27.

PMID: 16380096 [PubMed - indexed for MEDLINE]

5: Porrini S, Belloni V, Della Seta D, Farabollini F, Giannelli G,

Dessi-Fulgheri F.

Early exposure to a low dose of bisphenol A affects socio-sexual behavior

of juvenile female rats.

Brain Res Bull. 2005 Apr 15;65(3):261-6. Epub 2004 Dec 15.

PMID: 15811590 [PubMed - indexed for MEDLINE]

6: Della Seta D, Minder I, Dessi-Fulgheri F, Farabollini F.

Bisphenol-A exposure during pregnancy and lactation affects maternal

behavior in rats.

Brain Res Bull. 2005 Apr 15;65(3):255-60. Epub 2004 Dec 18.

PMID: 15811589 [PubMed - indexed for MEDLINE]

7: Masuo Y, Morita M, Oka S, Ishido M.

Motor hyperactivity caused by a deficit in dopaminergic neurons and the

effects of endocrine disruptors: a study inspired by the physiological

roles of PACAP in the brain.

Regul Pept. 2004 Dec 15;123(1-3):225-34.

PMID: 15518916 [PubMed - indexed for MEDLINE]

8: Ishido M, Masuo Y, Kunimoto M, Oka S, Morita M.

Bisphenol A causes hyperactivity in the rat concomitantly with impairment

of tyrosine hydroxylase immunoreactivity.

J Neurosci Res. 2004 May 1;76(3):423-33.

PMID: 15079872 [PubMed - indexed for MEDLINE]

9: i W, Seta DD, Dessi-Fulgheri F, Farabollini F, Laviola G.

Altered profiles of spontaneous novelty seeking, impulsive behavior, and

response to D-amphetamine in rats perinatally exposed to bisphenol A.

Environ Health Perspect. 2003 Apr;111(4):395-401. Erratum in: Environ Health

Perspect. 2005 Jun;113(6):A368.

PMID: 12676589 [PubMed - indexed for MEDLINE]

10: Kubo K, Arai O, Omura M, Watanabe R, Ogata R, Aou S.

Low dose effects of bisphenol A on sexual differentiation of the brain and

behavior in rats.

Neurosci Res. 2003 Mar;45(3):345-56.

PMID: 12631470 [PubMed - indexed for MEDLINE]

11: Kawai K, Nozaki T, Nishikata H, Aou S, Takii M, Kubo C.

Aggressive behavior and serum testosterone concentration during the

maturation

process of male mice: the effects of fetal exposure to bisphenol A.

Environ Health Perspect. 2003 Feb;111(2):175-8.

PMID: 12573901 [PubMed - indexed for MEDLINE]

12: Funabashi T, Sano A, Mitsushima D, Kimura F.

Bisphenol A increases progesterone receptor immunoreactivity in the

hypothalamus in a dose-dependent manner and affects sexual behaviour in adult

ovariectomized rats.

J Neuroendocrinol. 2003 Feb;15(2):134-40.

PMID: 12535155 [PubMed - indexed for MEDLINE]

13: Palanza PL, Howdeshell KL, Parmigiani S, vom Saal FS.

Exposure to a low dose of bisphenol A during fetal life or in adulthood

alters maternal behavior in mice.

Environ Health Perspect. 2002 Jun;110 Suppl 3:415-22.

PMID: 12060838 [PubMed - indexed for MEDLINE]

14: Farabollini F, Porrini S, Della Seta D, Bianchi F, Dessi-Fulgheri F.

Effects of perinatal exposure to bisphenol A on sociosexual behavior of

female

and male rats.

Environ Health Perspect. 2002 Jun;110 Suppl 3:409-14.

PMID: 12060837 [PubMed - indexed for MEDLINE]

15: Dessi-Fulgheri F, Porrini S, Farabollini F.

Effects of perinatal exposure to bisphenol A on play behavior of female and

male juvenile rats.

Environ Health Perspect. 2002 Jun;110 Suppl 3:403-7.

PMID: 12060836 [PubMed - indexed for MEDLINE]

16: Schantz SL, Widholm JJ.

Cognitive effects of endocrine-disrupting chemicals in animals.

Environ Health Perspect. 2001 Dec;109(12):1197-206. Review.

PMID: 11748026 [PubMed - indexed for MEDLINE]

17: Farabollini F, Porrini S, Dessi-Fulgherit F.

Perinatal exposure to the estrogenic pollutant bisphenol A affects

behavior in male and female rats.

Pharmacol Biochem Behav. 1999 Dec;64(4):687-94.

PMID: 10593191 [PubMed - indexed for MEDLINE]