Minocycline-induced lupus. A systematic review.

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Minocycline-induced lupus. A systematic review.

Schlienger RG, Bircher AJ, Meier CR.

Division of Clinical Pharmacology, University Hospital, Basel,

Switzerland. rschlienger@...

BACKGROUND: Minocycline has increasingly been associated with

different adverse auto-immune reactions including drug-induced lupus.

Objective: To identify the scope of minocycline-induced lupus and to

characterise its typical features. METHODS: Comprehensive Medline and

Embase search of the English and non-English literature for case

reports of minocycline-induced lupus. RESULTS: We included 57 cases

of minocycline-induced lupus (mean age +/- SD at onset: 21.6+/-8.6

years, median time of exposure: 19 months, range 3 days to 6 years).

All patients showed the clinical features of polyarthralgia/

polyarthritis often accompanied by liver abnormalities. Twelve

patients had evidence of dermatological manifestations (i.e rash,

livedo reticularis, oral ulceration, subcutaneous nodules, alopecia).

The ANA test was positive in all patients. CONCLUSION: Long-term

exposure to minocycline may be associated with drug-induced lupus.

Baseline and periodic liver function and ANA tests accompanied by

appropriate clinical monitoring are suggested for patients receiving

long-term minocycline therapy. Copyright 2000 S. Karger AG, Basel.

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