Bone histomorphometric changes in....

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Bone histomorphometric changes in cholestatic liver diseases.

Severe osteopenia is seen in patients with end-stage cholestatic

liver disease. M. Guichelaar and colleagues performed bone

histomorphometric analyses on iliac crest bone biopsies obtained from

PBC (n=22) and PSC (n=30) patients at the time of liver

transplantation. All patients had decreases in bone volume and

osteoid deposition. In females (n=34), but not males (n=18), markers

of bone resorption were increased and markers of bone formation were

decreased. The osteopenia in females is explained by these changes

in bone resorption/formation parameters, but the mechanism of

osteopenia in males is unclear. (Abstract 961)