[FWD: [ProstateCancerCommunityLeaders] Very BIG outcome study]

[Guest guest]

From Rick Ward.

If men are not screened and do not know they have PCa how can they be

treated?

Kathy

>

> Cancer. 2006 Oct 13; [Epub ahead of print]

>

> Survival of men with clinically localized prostate cancer treated with

> prostatectomy, brachytherapy, or no definitive treatment: impact of age

> at diagnosis.

>

> Tward JD, Lee CM, Pappas LM, Szabo A, Gaffney DK, Shrieve DC.

>

> Department of Radiation Oncology, Huntsman Cancer Hospital, University of

> Utah, Salt Lake City, Utah.

>

> BACKGROUND.: The optimal treatment for men with early stage prostate

> cancer remains undefined. Survival of such patients after surgery,

> brachytherapy, or no definitive therapy was investigated specifically

> to determine the impact of age at diagnosis.

> METHODS.: In all, 60,290 men diagnosed with organ-confined, low and moderate

> grade prostate cancer between 1988 and 2002 were retrospectively

> identified from centers participating in the National Cancer Institute's

> Surveillance, Epidemiology, and End Results (SEER) Program. Prostate

> cancer-specific mortality (PCSM) and any-cause mortality (ACM) were

> determined. Outcomes for patients treated by brachytherapy, surgery, or

> receiving no definitive treatment were compared using the Wilcoxon test,

> stratified by T-stage and grade, and using multivariate analysis.

> RESULTS.: The median follow-up time was 46 months (range, 0-189 months). For

> men under age 60 at diagnosis, PCSM at 10 years was 1.3%, 0.5%, and 3.7% for

> surgery, brachytherapy, and no definitive therapy, respectively. For men age

> 60 and older the PCSM was 3.8%, 5.3%, and 8.4%, respectively. On univariate

> and multivariate analysis, surgery and brachytherapy

> resulted in statistically equivalent PCSM and ACM, and both had a

> significantly lower PCSM and ACM versus no definitive therapy.

> CONCLUSIONS.: A better survival was observed in men treated with a

> definitive therapy. The magnitude of the benefit on PCSM or ACM was

> similar for both definitive therapies irrespective of age. Cancer 2006.

> © 2006 American Cancer

> Society.

>

> PMID: 17041884 [PubMed - as supplied by publisher]

> http://tinyurl.com/yc9uue

>

> Rick Ward

> www.PCaAwareness.net

>