RESEARCH - Diet and risk of RA in a prospective cohort

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J Rheumatol. 2005 Jul;32(7):1249-52.

Diet and risk of rheumatoid arthritis in a prospective cohort.

Pedersen M, Stripp C, Klarlund M, Olsen SF, Tjonneland AM, Frisch M.

OBJECTIVE: To assess the association between dietary factors and risk of

rheumatoid arthritis (RA) in a large prospective cohort. METHODS:

Information about dietary intake was obtained from a detailed

self-administered food frequency questionnaire completed by 57,053

individuals who participated in a prospective cohort. Linking the cohort to

the Danish National Patient Registry we identified patients who developed

RA. A rheumatologist scrutinized original medical records for these

individuals in order to confirm the diagnosis of RA. proportional

hazards regression analyses were performed for dietary and lifestyle

factors. RESULTS: The average time of followup in the cohort was 5.3 years

(range < 1 mo to 7.7 yrs). Sixty-nine individuals were identified with

confirmed incident RA. In multivariate models each increase in intake of 30

g fat fish (>/= 8 g fat/100 g fish) per day was associated with 49%

reduction in the risk of RA (p = 0.06), whereas medium fat fish (3-7 g

fat/100 g fish) was associated with significantly increased risk of RA.

Intake of fruit and coffee was not associated with risk of RA. Furthermore,

no associations were found between risk of RA and intake of a range of other

dietary factors including long chain fatty acids, olive oil, vitamins A, E,

C, D, zinc, selenium, iron, and meat.

CONCLUSION: The limited number of patients who developed RA during followup

of our large cohort prevented us from concluding that dietary factors are

unimportant as risk factors for RA. It appears, however, that if dietary

factors are important modifiers of RA risk, they must play a role more than

a few years before clinical diagnosis.

PMID: 15996059

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

5996059 & dopt=Abstract

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