RESEARCH - Relation of menstrual cycle phase to symptoms of RA

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Relation of menstrual cycle phase to symptoms of rheumatoid arthritis.

Latman NS.

Since progesterone and estrogen have been shown to exhibit

anti-inflammatory/anti-arthritic activity, women with rheumatoid arthritis

might be expected to have a reduction of some symptoms of rheumatoid

arthritis during the postovulatory phase of the menstrual cycle when the

plasma concentrations of these hormones increase. Daily examination of

symptoms during 69 menstrual cycles in 14 patients with rheumatoid arthritis

revealed that rheumatoid arthritis was significantly reduced during the

postovulatory phase of the menstrual cycle. This reduction was clinically

and statistically significant. The data presented in this report indicate

that some of the " spontaneous " fluctuations in rheumatoid arthritis symptoms

may be the result of changes in plasma concentrations of estrogen and

progesterone.

PMID: 6859063

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=6\

859063 & dopt=Abstract

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Mayo Clinic in Rochester

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s Hopkins Medicine

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