Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 CCP: The TestHere you go Bill..........Joyce M Emailing: test TESTS Test not listed? A/G Ratio A1c ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Ammonia Amylase ANA Antibody Tests Antiphospholipids Antithrombin Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bicarbonate Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcium Cardiac Biomarkers Cardiac Risk Cardiolipin Antibodies Catecholamines CBC CCP CD4 Cdiff CEA Celiac Disease Tests CF Gene Mutation Chem7 Chlamydia Chloride Cholesterol CK CK-MB CMP CMV CO2 Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity Cystatin C D-dimer DHEAS Differential DLDL EGFR EGFR [Her-1] Electrolytes Electrophoresis ESR Estrogen Estrogen Receptors Factor V Leiden Fecal Occult Blood Ferritin fFN Fibrinogen Flu Tests Folate Fructosamine FSH G6PD Genotypic Resistance GFR GGT Glucose Gonorrhea Gram Stain Growth Hormone H-pylori hCG HDL Hematocrit Hemoglobin Hemoglobin Variants Hepatitis A Hepatitis B Hepatitis C Her-2/neu Herpes HIV Antibody HLA-B27 Home Tests Homocysteine HPV hs-CRP IGF-1 Immunoelectrophoresis INR Insulin Iron Tests LDH LDL Lead LH Lipase Lipid Profile Lipoprotein Subfractions Liver Panel Lp(a) Lupus Anticoagulant Lyme Disease M/C Ratio Magnesium MCH MCHC MCV Mercury Metanephrines Microalbumin MMA Mono Myoglobin NT-proBNP O & P p24 Pap Smear Phosphorus Plasma Metanephrines Platelet Count Platelet Function Porphyrins Potassium Prealbumin Pregnancy Test Progesterone Progest. Receptors Prolactin Protein C Protein Electro. Protein S PSA PSEN1 PT PT 20210 PTH RBC RDW Renin Rheumatoid Factor RSV Rubella Semen Analysis Sensitivity Testing Serum Iron SHBG Sickle Cell Sodium Stool Culture Strep Throat Susceptiblity Testing Sweat Chloride Syphilis T3 T4 Tau/Aß42 TB Skin Test Testosterone Ther. Drug Monitoring Thyroglobulin TIBC TORCH Total Protein TPMT Transferrin Trichomonas Triglycerides Triple Screen Troponin Trypsin Trypsinogen TSH Tumor Markers Uric Acid Urinalysis Urine Culture Urine Metanephrines Urine Protein Viral Load Vitamin B12 Vitamin D WBC West Nile Virus ZPP CONDITIONS/DISEASES 's DiseaseAdrenal InsufficiencyAlcoholismAllergiesAlzheimer's DiseaseAnemiaAngina PectorisAnthraxArthritisAutoimmune DisordersBioterrorist AgentsBleeding DisordersBone Marrow DisordersBPHBreast CancerCeliac DiseaseCervical CancerCFSCHFChlamydiaColon CancerCVDCystic FibrosisDiabetesDiarrheaFibromyalgiaFolate DeficiencyGonorrheaGoutGraves' DiseaseGuillain-BarreHashimoto’s thyroiditisHeart DiseaseHeart AttackHemochromatosisHepatitisHerpesHIVHuman PapillomavirusHypercoagulable DisordersHyperthyroidismHypothyroidismInfertilityInflammatory Bowel DiseaseInsulin ResistanceJRAKidney DiseaseLead PoisoningLeukemiaLiver DiseaseLupusLyme DiseaseLymphomaMalnutritionMenopauseMetabolic SyndromeMultiple MyelomaMultiple SclerosisMPDOsteoarthritisOsteoporosisOvarian CancerPancreatic CancerPancreatic DiseasesPancreatic InsufficiencyPancreatitisPCOSPeptic UlcerPregnancyProstate CancerRheumatoid ArthritisSeptic ArthritisSickle Cell AnemiaSjögren’s SyndromeStaph Wound Infect.STDsStrokeSyphilisTesticular CancerThalassemiaThyroid DiseasesTrichomonasTuberculosisUTIVitamin B12 DeficiencyWest Nile Virus SCREENING NewbornsInfantsChildrenTeensYoung AdultsAdultsAdults 50+Pregnancy in the news understanding your tests inside the lab about this site site map send us your comments home -------------------------------------------------------------- Genetic Tests Home Testing Reference Ranges Screening Test Reliability Testing Tips Tests to Market Your Role -------------------------------------------------------------- CCP Also known as: Citrulline antibody, Anti-citrulline antibody, anti-cyclic citrullinated peptide antibody, anti-CCP Formal name: Cyclic Citrullinated Peptide Antibody Related tests: Rheumatoid Factor email this page print this article The Test -------------------------------------------------------- How is it used? When is it ordered? What does the test result mean? Is there anything else I should know? How is it used? Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that causes inflammation, pain, stiffness, and destructive changes in the hands, feet, and other joints throughout the body. There are a variety of treatments available to minimize the complications of RA, but they depend on making an accurate diagnosis and on beginning treatment before the development of significant joint damage. Rheumatoid factor (RF) has been the primary blood test used to detect RA and distinguish it from other types of arthritis and other inflammatory processes. However, the sensitivity and specificity of RF are not ideal; it can be negative in patients who have clinical signs of RA and positive in patients who do not. CCP can be useful in diagnosing early RA. An elevated CCP can be found in a significant number of patients who have a negative RF, the classic test for RA, and therefore can help to make a diagnosis. According to the American College of Rheumatology, CCP antibodies may be detected in about 50-60% of patients with early RA (as early as 3-6 months after the beginning of symptoms). Early detection and diagnosis of RA allows doctors to begin aggressive treatment of the condition, minimizing the associated complications and tissue damage. CCP may also be ordered to help evaluate the likely development of RA in patients with undifferentiated arthritis (those whose symptoms suggest but do not yet meet the criteria of RA). The reason it is useful in confounding clinical presentations is that CCP is a more specific test for RA then the traditional RF. According to American College of Rheumatology, approximately 95% of patients with a positive CCP will develop RA in the future. [back to top] When is it ordered? CCP is primarily ordered along with an RF test when a patient has previously undiagnosed inflammatory arthritis or has been diagnosed with undifferentiated arthritis. It may be ordered as a follow-up test to a negative RF test when clinical signs, such as symmetrical joint pain and inflammation, lead the doctor to suspect RA. [back to top] What does the test result mean? As a rule, test results outside the context of clinical symptoms and signs cannot be judged. Nonetheless, if a patient is positive for both CCP and RF, it is very likely that they have RA and it is likely that they may develop a more severe form of the disease. If a patient is positive for CCP but not RF and clinical signs suggest RA, then it is likely that they have early RA or that they will develop RA in the future. If a patient is negative for CCP but has a positive RF, then the clinical symptoms and signs are more vital in determining whether a patient has RA versus some other inflammatory condition. If a patient is negative for both CCP and RF, then it is less likely that they have RA. It must be emphasized, however, that RA is a clinical diagnosis and may be made in the absence of positive autoantibodies. [back to top] Is there anything else I should know? The CCP test is promising but not yet widely used. Its ultimate clinical usefulness and the ways in which it will be used have yet to be determined. [back to top] This page was last modified on January 15, 2005. In the News • Understanding Your Tests • Inside the Lab About the Site • Site Map • Send Us Your Comments • Home ©2001-2005 American Association for Clinical Chemistry Email concerns to Terms of Use • Privacy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 CCP: The TestHere you go Bill..........Joyce M Emailing: test TESTS Test not listed? A/G Ratio A1c ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Ammonia Amylase ANA Antibody Tests Antiphospholipids Antithrombin Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bicarbonate Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcium Cardiac Biomarkers Cardiac Risk Cardiolipin Antibodies Catecholamines CBC CCP CD4 Cdiff CEA Celiac Disease Tests CF Gene Mutation Chem7 Chlamydia Chloride Cholesterol CK CK-MB CMP CMV CO2 Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity Cystatin C D-dimer DHEAS Differential DLDL EGFR EGFR [Her-1] Electrolytes Electrophoresis ESR Estrogen Estrogen Receptors Factor V Leiden Fecal Occult Blood Ferritin fFN Fibrinogen Flu Tests Folate Fructosamine FSH G6PD Genotypic Resistance GFR GGT Glucose Gonorrhea Gram Stain Growth Hormone H-pylori hCG HDL Hematocrit Hemoglobin Hemoglobin Variants Hepatitis A Hepatitis B Hepatitis C Her-2/neu Herpes HIV Antibody HLA-B27 Home Tests Homocysteine HPV hs-CRP IGF-1 Immunoelectrophoresis INR Insulin Iron Tests LDH LDL Lead LH Lipase Lipid Profile Lipoprotein Subfractions Liver Panel Lp(a) Lupus Anticoagulant Lyme Disease M/C Ratio Magnesium MCH MCHC MCV Mercury Metanephrines Microalbumin MMA Mono Myoglobin NT-proBNP O & P p24 Pap Smear Phosphorus Plasma Metanephrines Platelet Count Platelet Function Porphyrins Potassium Prealbumin Pregnancy Test Progesterone Progest. Receptors Prolactin Protein C Protein Electro. Protein S PSA PSEN1 PT PT 20210 PTH RBC RDW Renin Rheumatoid Factor RSV Rubella Semen Analysis Sensitivity Testing Serum Iron SHBG Sickle Cell Sodium Stool Culture Strep Throat Susceptiblity Testing Sweat Chloride Syphilis T3 T4 Tau/Aß42 TB Skin Test Testosterone Ther. Drug Monitoring Thyroglobulin TIBC TORCH Total Protein TPMT Transferrin Trichomonas Triglycerides Triple Screen Troponin Trypsin Trypsinogen TSH Tumor Markers Uric Acid Urinalysis Urine Culture Urine Metanephrines Urine Protein Viral Load Vitamin B12 Vitamin D WBC West Nile Virus ZPP CONDITIONS/DISEASES 's DiseaseAdrenal InsufficiencyAlcoholismAllergiesAlzheimer's DiseaseAnemiaAngina PectorisAnthraxArthritisAutoimmune DisordersBioterrorist AgentsBleeding DisordersBone Marrow DisordersBPHBreast CancerCeliac DiseaseCervical CancerCFSCHFChlamydiaColon CancerCVDCystic FibrosisDiabetesDiarrheaFibromyalgiaFolate DeficiencyGonorrheaGoutGraves' DiseaseGuillain-BarreHashimoto’s thyroiditisHeart DiseaseHeart AttackHemochromatosisHepatitisHerpesHIVHuman PapillomavirusHypercoagulable DisordersHyperthyroidismHypothyroidismInfertilityInflammatory Bowel DiseaseInsulin ResistanceJRAKidney DiseaseLead PoisoningLeukemiaLiver DiseaseLupusLyme DiseaseLymphomaMalnutritionMenopauseMetabolic SyndromeMultiple MyelomaMultiple SclerosisMPDOsteoarthritisOsteoporosisOvarian CancerPancreatic CancerPancreatic DiseasesPancreatic InsufficiencyPancreatitisPCOSPeptic UlcerPregnancyProstate CancerRheumatoid ArthritisSeptic ArthritisSickle Cell AnemiaSjögren’s SyndromeStaph Wound Infect.STDsStrokeSyphilisTesticular CancerThalassemiaThyroid DiseasesTrichomonasTuberculosisUTIVitamin B12 DeficiencyWest Nile Virus SCREENING NewbornsInfantsChildrenTeensYoung AdultsAdultsAdults 50+Pregnancy in the news understanding your tests inside the lab about this site site map send us your comments home -------------------------------------------------------------- Genetic Tests Home Testing Reference Ranges Screening Test Reliability Testing Tips Tests to Market Your Role -------------------------------------------------------------- CCP Also known as: Citrulline antibody, Anti-citrulline antibody, anti-cyclic citrullinated peptide antibody, anti-CCP Formal name: Cyclic Citrullinated Peptide Antibody Related tests: Rheumatoid Factor email this page print this article The Test -------------------------------------------------------- How is it used? When is it ordered? What does the test result mean? Is there anything else I should know? How is it used? Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that causes inflammation, pain, stiffness, and destructive changes in the hands, feet, and other joints throughout the body. There are a variety of treatments available to minimize the complications of RA, but they depend on making an accurate diagnosis and on beginning treatment before the development of significant joint damage. Rheumatoid factor (RF) has been the primary blood test used to detect RA and distinguish it from other types of arthritis and other inflammatory processes. However, the sensitivity and specificity of RF are not ideal; it can be negative in patients who have clinical signs of RA and positive in patients who do not. CCP can be useful in diagnosing early RA. An elevated CCP can be found in a significant number of patients who have a negative RF, the classic test for RA, and therefore can help to make a diagnosis. According to the American College of Rheumatology, CCP antibodies may be detected in about 50-60% of patients with early RA (as early as 3-6 months after the beginning of symptoms). Early detection and diagnosis of RA allows doctors to begin aggressive treatment of the condition, minimizing the associated complications and tissue damage. CCP may also be ordered to help evaluate the likely development of RA in patients with undifferentiated arthritis (those whose symptoms suggest but do not yet meet the criteria of RA). The reason it is useful in confounding clinical presentations is that CCP is a more specific test for RA then the traditional RF. According to American College of Rheumatology, approximately 95% of patients with a positive CCP will develop RA in the future. [back to top] When is it ordered? CCP is primarily ordered along with an RF test when a patient has previously undiagnosed inflammatory arthritis or has been diagnosed with undifferentiated arthritis. It may be ordered as a follow-up test to a negative RF test when clinical signs, such as symmetrical joint pain and inflammation, lead the doctor to suspect RA. [back to top] What does the test result mean? As a rule, test results outside the context of clinical symptoms and signs cannot be judged. Nonetheless, if a patient is positive for both CCP and RF, it is very likely that they have RA and it is likely that they may develop a more severe form of the disease. If a patient is positive for CCP but not RF and clinical signs suggest RA, then it is likely that they have early RA or that they will develop RA in the future. If a patient is negative for CCP but has a positive RF, then the clinical symptoms and signs are more vital in determining whether a patient has RA versus some other inflammatory condition. If a patient is negative for both CCP and RF, then it is less likely that they have RA. It must be emphasized, however, that RA is a clinical diagnosis and may be made in the absence of positive autoantibodies. [back to top] Is there anything else I should know? The CCP test is promising but not yet widely used. Its ultimate clinical usefulness and the ways in which it will be used have yet to be determined. [back to top] This page was last modified on January 15, 2005. In the News • Understanding Your Tests • Inside the Lab About the Site • Site Map • Send Us Your Comments • Home ©2001-2005 American Association for Clinical Chemistry Email concerns to Terms of Use • Privacy Quote Link to comment Share on other sites More sharing options...
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