Re: NEWS: New Approach to Rheumatoid Arthritis Therapy Under Development

[Guest guest]

Thanks for the info. For people with moderate to severe RA, the anti-

TNFa therapies they refer to are the new " biologicals " such as Enbrel

and Humira. I don't think methotrexate targets TNF... does anybody

know?

Nina

[Guest guest]

Thanks for the info. For people with moderate to severe RA, the anti-

TNFa therapies they refer to are the new " biologicals " such as Enbrel

and Humira. I don't think methotrexate targets TNF... does anybody

know?

Nina

[Guest guest]

Well, Nina, MTX has been used for decades without knowing precisely why it

is effective in RA. Recent research has shown that, among its other

anti-inflammatory effects, MTX does interfere with the TNF pathway, but,

seemingly, primarily on the production end.

The anti-TNF biologics - Enbrel (etanercept), Remicade (infliximab), and

Humira (adalimumab) - inhibit TNF after production.

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: NEWS: New Approach to Rheumatoid Arthritis Therapy

Under Development

>

>

>

> Thanks for the info. For people with moderate to severe RA, the anti-

> TNFa therapies they refer to are the new " biologicals " such as Enbrel

> and Humira. I don't think methotrexate targets TNF... does anybody

> know?

>

> Nina

[Guest guest]

Well, Nina, MTX has been used for decades without knowing precisely why it

is effective in RA. Recent research has shown that, among its other

anti-inflammatory effects, MTX does interfere with the TNF pathway, but,

seemingly, primarily on the production end.

The anti-TNF biologics - Enbrel (etanercept), Remicade (infliximab), and

Humira (adalimumab) - inhibit TNF after production.

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: NEWS: New Approach to Rheumatoid Arthritis Therapy

Under Development

>

>

>

> Thanks for the info. For people with moderate to severe RA, the anti-

> TNFa therapies they refer to are the new " biologicals " such as Enbrel

> and Humira. I don't think methotrexate targets TNF... does anybody

> know?

>

> Nina