Re: more Questions and general information

[Guest guest]

Hi Carolyn.

Remember when I wrote that IgA nephropathy can sometimes be secondary to

another disease. Well, that's what I meant. Celiac sprue (or celiac disease,

which is gluten intolerance) is one of those, as is ulcerative colitis. I

don't think the mechanisms for that have been completely figured out yet,

but it somehow results in the depostion of IgA complexes in the kidneys. The

idea of cutting out all gluten (easier said than done, since a completely

wheat-free diet is not a an easy thing to maintain in today's world) is that

it will reduce the amount of circulating IgA/C3 complexes, and thus reduce

the IgA nephropathy. I don't know for sure if the theory translates well

into reality, but it does seem logical that cutting gluten out of the diet

might help to solve the problem (and it will certainly help with the gluten

intolerance overall) -- but I'm not an expert in celiac disease. C3 is a

glycoprotein complement, a component of the overall immune system. Some

recent studies have shown that it may be possible to more accurately

diagnose IgAN without a biopsy by checking for those in the blood.

It has also been suggested that avoiding gluten might help with just

ordinary IgAN. Again, this is unproven I think. There doesn't seem to be any

hard evidence that reducing the levels of circulating IgA proteins has any

effect on the actual deposition of these IgA complexes in the kidneys.

I suppose anyone could experiment with this on their own and see what

happens in their subsequent lab results. Were talking about ongoing

scientific research here, so I couldn't say one way or another.

The list of conditions that can cause IgA nephropathy-like deposits is long,

and I think most doctors would look for symptomology in order to eliminate

them. This is something you have to work with your doctor on. Maybe he or

she has already considered these things.

As for HSP, here is a good site where you can get pretty much all the

information you need on it. HSP doesn't always affect the kidneys, but when

it does, it produces the exact same pathology as does IgAN. In fact, some

researchers think that IgAN and HSP are the same disease, and that some

people only get the kidney involvement part of HSP. This may be why stomach

pain complaints are so common among patients with IgA nephropathy.

Pierre

more Questions and general information

>

>

> > Hi:

> > I came back yesterday talking to my doc about other symptoms of IgA

than

> > just the kidneys-1/3 patients have IgA depostition in gluten entropathy,

> > Institution of a gluten free diet with circulating antibiodies results

in

> a

> > reduction in hematuria and proteinuria in most cases. IgA Nepropathy has

> > been infrequently associated with a variety of other diseases:

dermatitis

> > herpetiformis,seronegative arthritis (particularily ankylosing

> spondylitis,

> > small cell carcinoma, disseminated tuberculosis, bronchiolitis

obliterans,

> > mycosis fungoids.

> > www.kidneydoctor.com under IgA Nephropathy.

> > Under article under Virtual Hospital

> > secondary deposits of IgA may occur in chronic liver disease, dermatitis

> > herpetiform, psoriasis, ankylosing spndylitis, celiac disease,

> inflammatory

> > bowel disease (such as ulcerative colitis and Crohn's disease),

carcinoma,

> > IgA monoclonal gammatherapy, HIV infection, and mycosis fungiodes.

> >

> > Does anyone know of these?

> > I am now being sent to the GI to have a full colonoscopy to address my

> > gastro-inte complaints. Suspicion that I have some kind of inflammatory

> > bowel disease whose treatments consists of usage of NSAIDS-not good for

> > kidneys. Also I had C3 deposits in my kidneys-what are these?

> >

> > What is HSP exactly?

> > Is there a test for it?

> > Carolyn

> >

> >

>

>

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>

>

>

[Guest guest]

Oops! forgot to insert the link for that HSP webpage:

http://www.medicinenet.com/script/main/Art.asp?li=MNI & ArticleKey=389

Pierre

more Questions and general information

>

>

> >

> >

> > > Hi:

> > > I came back yesterday talking to my doc about other symptoms of IgA

> than

> > > just the kidneys-1/3 patients have IgA depostition in gluten

entropathy,

> > > Institution of a gluten free diet with circulating antibiodies results

> in

> > a

> > > reduction in hematuria and proteinuria in most cases. IgA Nepropathy

has

> > > been infrequently associated with a variety of other diseases:

> dermatitis

> > > herpetiformis,seronegative arthritis (particularily ankylosing

> > spondylitis,

> > > small cell carcinoma, disseminated tuberculosis, bronchiolitis

> obliterans,

> > > mycosis fungoids.

> > > www.kidneydoctor.com under IgA Nephropathy.

> > > Under article under Virtual Hospital

> > > secondary deposits of IgA may occur in chronic liver disease,

dermatitis

> > > herpetiform, psoriasis, ankylosing spndylitis, celiac disease,

> > inflammatory

> > > bowel disease (such as ulcerative colitis and Crohn's disease),

> carcinoma,

> > > IgA monoclonal gammatherapy, HIV infection, and mycosis fungiodes.

> > >

> > > Does anyone know of these?

> > > I am now being sent to the GI to have a full colonoscopy to address my

> > > gastro-inte complaints. Suspicion that I have some kind of

inflammatory

> > > bowel disease whose treatments consists of usage of NSAIDS-not good

for

> > > kidneys. Also I had C3 deposits in my kidneys-what are these?

> > >

> > > What is HSP exactly?

> > > Is there a test for it?

> > > Carolyn

> > >

> > >

> >

> >

> > eGroups Sponsor

> >

> >

> >