Renal stones in patients with rheumatoid arthritis.

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J Rheumatol. 1997 Nov;24(11):2123-8. Related Articles, Links

Renal stones in patients with rheumatoid arthritis.

Ito S, Nozawa S, Ishikawa H, Tohyama C, Nakazono K, Murasawa A, Nakano M,

Arakawa M.

Department of Medicine, Niigata Prefectural Senami Hospital, Niigata

University School of Medicine, Japan.

OBJECTIVE: Renal stones are reported to be one of the causes of hematuria in

patients with juvenile rheumatoid arthritis (RA). We performed abdominal

ultrasonography on patients with RA to investigate the frequency of renal

stones and whether renal stones are related to hematuria. METHODS: We

conducted abdominal ultrasonography in 224 patients with RA (42 men, 182

women). Mean age was 61.4 years, and the mean duration of disease was 13.5

years. RESULTS: Renal stones were defined as hyperechoic spots with acoustic

shadows, and they were observed in 37 patients. We also noticed hyperechoic

spots without acoustic shadows in 50 patients. Five of these 50 patients

also had renal stones. Twenty-one patients showing hyperechoic spots without

acoustic shadows underwent computed tomographic scans, and apparent

calcifications were observed in 10 patients. Age and sex matched controls

had a significantly lower incidence of renal stones and hyperechoic spots

without acoustic shadows than did patients with RA. Hematuria was more

frequently observed in patients with RA with renal stones than in those

without renal stones or hyperechoic spots without acoustic shadows. Urinary

calcium/creatinine (Ca/Cr) ratios were elevated in patients compared to

controls. Urinary Ca/Cr ratios in patients taking vitamin D3 were higher

than those of patients not receiving the vitamin. Administration of vitamin

D3 also was associated with increased incidence of renal stones. CONCLUSION:

We observed a high incidence of renal stones in patients with RA. Hematuria

was more prevalent in patients with RA with renal stones than in those

without. These results suggest the importance of performing abdominal

ultrasonography on patients with RA.

PMID: 9375870

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=9375870 & itool=iconabstr & query_hl=4

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